1. A Phenolic Extract Obtained from Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line.
- Author
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Spagnuolo C, Flores G, Russo GL, and Ruiz Del Castillo ML
- Subjects
- Acetates pharmacology, Anthocyanins analysis, Anthocyanins chemistry, Anthocyanins metabolism, Anthocyanins therapeutic use, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic therapeutic use, Antioxidants analysis, Antioxidants chemistry, Antioxidants metabolism, Antioxidants therapeutic use, Cell Survival, Crops, Agricultural chemistry, Crops, Agricultural drug effects, Crops, Agricultural growth & development, Cyclopentanes pharmacology, Dietary Supplements, Ellagic Acid analogs & derivatives, Ellagic Acid chemistry, Ellagic Acid metabolism, Ellagic Acid therapeutic use, Female, Fragaria drug effects, Fragaria growth & development, Fruit drug effects, Fruit growth & development, Glucosides analysis, Glucosides chemistry, Glucosides metabolism, Glucosides therapeutic use, HeLa Cells, Humans, Molecular Structure, Oxylipins pharmacology, Phenols analysis, Phenols chemistry, Phenols therapeutic use, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Extracts therapeutic use, Plant Growth Regulators pharmacology, Polyphenols analysis, Polyphenols chemistry, Polyphenols metabolism, Polyphenols therapeutic use, Spain, Uterine Cervical Neoplasms diet therapy, Uterine Cervical Neoplasms pathology, Antineoplastic Agents, Phytogenic metabolism, Apoptosis, Fragaria chemistry, Fruit chemistry, Phenols metabolism, Plant Extracts metabolism, Uterine Cervical Neoplasms metabolism
- Abstract
In the present study, we evaluated the effect of methyl jasmonate (MeJA) treatment on strawberry phenolic composition. Strawberry extracts contain a mixture of phenolic compounds possessing several biological properties. We demonstrated that these extracts were more effective in inducing apoptosis in HeLa cells compared to phenolic preparations derived from untreated strawberries. Treatment of strawberries with 0.5% MeJA resulted in increased polyphenols content (from 7.4 to 8.6 mM quercetin equivalents) and antioxidant properties (from 3.9 to 4.6 mM quercetin equivalents). The identification and quantification of phenolic compounds by liquid chromatography-mass spectrometry in the strawberry extracts showed that cyanidin glucoside, pelargonidin glucoside, and ellagic glucoside acid were significantly higher in strawberries treated with MeJA. Phenolic extracts from MeJA-treated strawberries significantly decreased the cell viability in HeLa cells, compared to extracts derived from untreated fruits. We hypothesized that the enhanced apoptotic activity of MeJA-treated strawberries was due to a synergistic or additive effect of different phenolic compounds present in the extract, rather than the activity of a single molecule.
- Published
- 2016
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