1. Palladacycle promoted asymmetric hydrophosphination of α,β-unsaturated sulfonyl fluorides
- Author
-
Houguang Jeremy Chen, Yongxin Li, Sumod A. Pullarkat, Yu Chen, Mengtao Ma, Xi-Rui Li, Pak-Hing Leung, and Weifan Wang
- Subjects
Sulfonyl ,chemistry.chemical_classification ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Enantioselective synthesis ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,0104 chemical sciences ,Catalysis ,Inorganic Chemistry ,Metal ,chemistry.chemical_compound ,Nucleophile ,visual_art ,Intramolecular force ,Materials Chemistry ,visual_art.visual_art_medium ,Physical and Theoretical Chemistry ,Fluoride ,Phosphine - Abstract
The first example of an enantioselective hydrophosphination reaction of ethenesulfonyl fluoride derivatives catalyzed by a phosphapalladacycle afforded chiral sulfonyl fluoride-derived phosphines in quantitative yields and enantioselectivities of up to 93% ee. Investigations revealed the importance of adjacent vacant sites within the active metal center for intramolecular nucleophilic attack to provide the functionalized phosphine.
- Published
- 2019