1. Phospholipase C-γ: diverse roles in receptor-mediated calcium signaling
- Author
-
Patterson, Randen L., van Rossum, Damian B., Nikolaidis, Nikolas, Gill, Donald L., and Snyder, Solomon H.
- Subjects
- *
CALCIUM , *PHOSPHOLIPASES , *MOLECULES , *LIPASES , *ENZYMES - Abstract
Ca2+ is a universal signal: the dynamic changes in its release and entry trigger a plethora of cellular responses. Central to this schema are members of the phospholipase C (PLC) superfamily, which relay information from the activated receptor to downstream signal cascades by production of second-messenger molecules. Recent studies reveal that, in addition to its enzymatic activity, PLC-γ regulates Ca2+ entry via the formation of an intermolecular lipid-binding domain with canonical transient receptor potential 3 (TRPC3) ion channels. This complex, in turn, controls TRPC3 trafficking and cell-surface expression. Thus, TRPC3 ion channels are functionally linked to both lipase-dependent and -independent activities of PLC-γ. Understanding the underlying molecular mechanisms that regulate this complex will probably clarify the processes of receptor-activated Ca2+ entry. [Copyright &y& Elsevier]
- Published
- 2005
- Full Text
- View/download PDF