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Photodynamic therapy (PDT) of cancer has been known for over twenty years and is based on the dye-sensitized photooxidation of different biological targets in the tumoral tissue, yielding to a photochemically induced cell's death via mainly apoptotic pathways. The effectiveness of this therapy depends on the photophysical and photochemical properties of the photosensitizer-drug. The purpose of this paper is to evaluate a series of aluminium phthalocyanine sensitizers compounds, in terms of photodynamic activity correlation with their structure using standard human dysplazic oral kerotinocytes cell line (DOK). The photodynamic action of some aluminium sulphonated-phthalocyanines, with different sulphonation degree (AlS2Pc, AlS4Pc), is discussed in this matter. The in vitro photodynamic treatment (PDT) induced a drastic lethal effect on DOK cells attributed to the active singlet oxygen photochemically generated by aluminium sulphonatedphthalocyanines. The tested photosensitizers induce early membrane damage and upon irradiation AlS2Pc compound is the most efficient in actively killing the tumoral cells. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a modern procedure used in dermatology mainly in the treatment of cutaneous malignant tumours (e.g. basal cell carcinoma, squamous cell carcinoma, Kaposis's sarcoma, mycosis fungoides) and premalignant lesions (e.g. actinic keratoses, Bowen's disease, dysplasia and erythroplasia of oral mucosa, erythroplasia of Queyrat). The procedure requires a photosensitiser (PS) able to be selectively accumulated in the tumoral tissue and a light source capable of emitting radiation of an appropriate wavelength in order to activate the photosensitiser. This paper aims at reviewing the basic principles of PDT and the criteria for choosing the photosensitiser, the light source and the adequate values of the physical parameters used in order to obtain optimal therapeutic results with minimal adverse reactions in dermato-oncologic PDT. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a modern procedure used in dermatology mainly in the treatment of cutaneous malignant tumours (e.g. basal cell carcinoma, squamous cell carcinoma, Kaposis's sarcoma, mycosis fungoides) and premalignant lesions (e.g. actinic keratoses, Bowen's disease, dysplasia and erythroplasia of oral mucosa, erythroplasia of Queyrat). The procedure requires a photosensitiser (PS) able to be selectively accumulated in the tumoral tissue and a light source capable of emitting radiation of an appropriate wavelength in order to activate the photosensitiser. This paper aims at reviewing the basic principles of PDT and the criteria for choosing the photosensitiser, the light source and the adequate values of the physical parameters used in order to obtain optimal therapeutic results with minimal adverse reactions in dermato-oncologic PDT. [ABSTRACT FROM AUTHOR]