1. Fixed-point "blasting" triggered by second near-infrared window light for augmented interventional photothermal therapy.
- Author
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Cao Y, Ouyang B, Yang X, Jiang Q, Yu L, Shen S, Ding J, and Yang W
- Subjects
- Animals, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Biocompatible Materials chemical synthesis, Biocompatible Materials chemistry, Cell Proliferation drug effects, Cell Survival drug effects, Cyclopentanes chemistry, Drug Screening Assays, Antitumor, Fluorocarbons chemistry, HCT116 Cells, HEK293 Cells, Humans, Hydrogels chemical synthesis, Hydrogels chemistry, Infrared Rays, Mice, Mice, Inbred BALB C, Neoplasms, Experimental drug therapy, Neoplasms, Experimental pathology, Polyethylene Glycols chemical synthesis, Polyethylene Glycols chemistry, Polyglactin 910 chemical synthesis, Polyglactin 910 chemistry, Antineoplastic Agents pharmacology, Biocompatible Materials pharmacology, Cyclopentanes pharmacology, Fluorocarbons pharmacology, Hydrogels pharmacology, Nanoparticles chemistry, Photothermal Therapy, Polyethylene Glycols pharmacology, Polyglactin 910 pharmacology
- Abstract
One of the major limitations of current cancer therapy is the inability to destroy tumors with high efficacy and minimal invasiveness. Herein, we developed a proof-of-concept fixed-point "blasting" strategy to destroy the "castle" of tumors and realized efficient interventional photothermal therapy. The "blasting" materials were composed of photothermal nanoparticles (ancient ink nanoparticles, AINP) and a low boiling point phase change agent (perfluoromethylcyclopentane, FMCP). An injectable in situ-forming thermal-responsive hydrogel composed of biodegradable and biocompatible polymers was employed as a carrier to load the AINP and FMCP. The obtained hydrogel system was a flowable aqueous solution at low or room temperature for facile injection; meanwhile, once administered, it rapidly transformed into a fixed gel at a body temperature of about 37 °C. This unique property could effectually fix the AINP and FMCP and thus restrict the destruction region inside the tumor. Subsequently, triggered by second window near-infrared light, the solid tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage. We envisage that this fixed-point "blasting" strategy will pave a new way for the next generation of cancer-interventional photothermal therapy.
- Published
- 2020
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