Questions of meaning may seem more properly suited to the spheres of religion or philosophy; yet physicians certainly witness some of the greatest sufferings of their patients' lives, and through this suffering, many patients look to their doctors not just for treatments but for answers. In this essay, the author highlights an exchange between patient and doctor in Thomas Wolfe's Look Homeward, Angel, to argue that physicians need not have ready made answers about life, meaning, or spirituality, but should indeed provide comfort and support when their patients ask: "What's it all about?" [ABSTRACT FROM AUTHOR]