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Ethnopharmacological Relevance: Plants are traditionally used in Algeria to treat many disorders, including diabetes mellitus. Knowledge of the plants that are used may provide insight on their properties, for further exploration. This study reviewed all the available published and unpublished reports concerning the use of herbal medicines in the treatment of diabetes in Algeria., Aim of the Study: To describe the plants used in Algeria to treat diabetes, as reported in the literature., Material and Methods: Systematic review of ethnobotanical papers published in the medical literature, from literature databases (Pubmed, Web of Science), as well as Google, for English, French and Arabic -language publication, and a manual search of local libraries and bookshops, as well as the university repository of PhD and master's theses. The reference lists of the papers retrieved were also examined for further papers., Results: Many plants are cited in the ethnobotanical surveys, but only very few pharmacological studies were found. In the ethnobotanical surveys, 171 plants were reported, from 58 families of which the most often cited were Asteraceae, Lamiaceae and Apiaceae. The plants with the best evidence of use and activity are: Anabasis articulata (Forssk.) Moq., Trigonella foenum-graecum L., Centaurium erythraea Rafn, Artemisia herba-alba Asso, Marrubium vulgare L., Agathophora alopecuroides (Delile) Fenzl ex Bunge, Anabasis articulata (Forssk.) Moq., Hammada elegans (Bunge) Botsch., Helianthemum kahiricum Delile, Salsola baryosma (Schult.) Dandy, Salsola vermiculata L., Olea europaea L., Conclusion: Traditional herbal medicines are still very much used in Algeria to control diabetes. However they are generally poorly characterized and none have been properly tested in man. There is a need for systematic evaluation of the more commonly used plants to confirm their antidiabetic activity, identify possible mechanimss of action, and recommend best use., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Ethnopharmacological Relevance: Trigonella foenum-graecum L. (TFG) is traditionally used to treat diabetes in North Africa. we therefore tested the effects of the hydro-alcoholic extract of TFG seeds in a C57/BL6J mouse model of diabetes induced by a standardised high-fat diet (HFD)., Materials and Methods: Plant extracts (2 g/kg daily) were administered orally by gavage at the start of HFD, or after confirmation of established diabetes (17th week), for 20 or 18 weeks, respectively, to male C57BL/6J mice. Animals were weighed; food intake and plasma glucose, lipid profile, insulin and insulin resistance were measured., Results: TFG extracts opposed the development of diabetes: compared with untreated HFD mice, TFG-treated HFD mice had lower mean (± SD) plasma glucose (129.3 ± 39.4 vs. 183.1 ± 19.1mg/dL, p<0.05), plasma insulin (1.3 ± 0.8 vs. 3.1 ± 1.8 ng/mL, p<0.05) and triglycerides (18.9 ± 12.9 vs. 48.9 ± 12.1mg/dL, p<0.05), and less insulin resistance as estimated by the homeostasis model assessment (HOMA: 9.7 ± 11.1 vs. 38.3 ± 26.6, p<0.05). In mice with established diabetes, TFG reduced fasting plasma glucose (170.4 ± 24.1 vs. 229.0 ± 20.8 mg/dL, p<0.05), plasma insulin (1.7 ± 1.3 vs. 3.3 ± 14.3 ng/mL, p<0.05) and insulin resistance (HOMA: TFG: 19.2 ± 15.7 vs. HFD control: 38.5 ± 30.3, p<0.05). In addition, administration of TFG extract also caused significant reduction in triglycerides (17.9 ± 9.7 vs. 62.8 ± 18.3 mg/dL, p<0.05) and total cholesterol (1.30 ± 0.20 vs. 1.80 ± 1.10 g/L, p<0.05), and an increase in HDL-cholesterol (1.6 ± 0.2 vs. 1.2 ± 0.1 g/L). The plant extract had no effect on calorie intake or body weight., Conclusion: TFG extract opposed the development of experimental HFD diabetes in mice, and had an anti-diabetic effect in mice with established diabetes., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Aim of the Study: Hydro-alcoholic extracts of Centaurium erythraea Rafn (CE), Gentianaceae and Artemisia herba-alba Asso (AHA), Asteraceae, medicinal plants used in traditional treatment of diabetes in north-eastern Algeria, were tested in established type 2 diabetes induced with a standardized high fat diet (HFD) in mice., Materials and Methods: After confirmation of diabetes (17th week), plant extracts were administered orally by gavage at a dose of 2 g/kg daily for 18 weeks to male C57BL/6J mice fed HFD. Animals were weighed, food intake and plasma glucose measured weekly, insulin and lipid profile at study end., Results: At 35 weeks, groups treated with AHA or CE vs. HFD control had a significant reduction in mean (±SD) fasting blood glucose concentrations (143.8±23.9 and 139.5±14.2 vs. 229.0±20.8 mg/dL, p<0.05, respectively), triglyceride (18.9±11.1 and 16.0±6.5 vs. 62.8±18.3 mg/dL, p<0.05), total cholesterol (1.2±0.1 and 1.2±0.3 vs. 1.8±1.1 g/L, p<0.05) and serum insulin concentrations (1.7±0.7 and 0.9±0.7 vs. 3.3±14.3 ng/mL, p<0.05). Plant extracts also markedly reduced insulin resistance as compared to HFD controls (AHA: 15.6±9.1, CE: 9.0±7.7 vs. HFD control 38.5±30.3, p<0.05). The plant extracts decreased calorie intake and had little effect on body weight or HDL-cholesterol., Conclusion: AHA has already been shown to have a antihyperglycaemic and antihyperlipidemic effect but this is the first demonstration of an effect of AHA and CE on established HFD-induced diabetes., (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)

Aim of the Study: The preventive effect of the hydro-alcoholic extracts of Artemisia herba-alba Asso (AHA), and Centaurium erythraea Rafn (CE), two medicinal plants used in traditional treatment of diabetes in the north-eastern Algeria, were evaluated in animal models of type 2 diabetic induced with a standardised high fat diet (HFD)., Materials and Methods: Plant extracts were administered orally by gavage at a dose of 2g/kg bodyweight daily for 20 weeks to male C57BL/6J mice fed HFD. Animals were weighed and plasma glucose measured weekly and insulin at the end of study using standard ELISA methods., Results: After 6 weeks, blood glucose levels increased in HFD control mice. At end of study (20 weeks) in groups treated with AHA or CE extracts vs. HFD control group there was a significant reduction in mean (+/-SD) fasting blood glucose (respectively 108.0+/-42.0 and 120.4+/-45.1 vs. 183.1+/-19.1mg/dl, p<0.05), triglyceride concentrations (26.9+/-6.7 and 27.9+/-17.8 vs. 48.9+/-12.1mg/dl, p<0.05) and serum insulin levels (1.1+/-1.0 and 0.6+/-0.7 vs. 3.1+/-1.8 ng/ml, p<0.05). Plant extracts also markedly reduced insulin resistance as measured by the homeostasis model assessment (HOMA) compared to HFD controls (AHA: 4.4+/-5.3, CE: 3.0+/-3.3 vs. HFD control 38.3+/-26.6, p<0.05). The plant extracts had no effect on calorie intake or body weight., Conclusion: AHA had been shown to have a hypoglycaemic effect in diabetes but this is the first demonstration of a preventive effect of AHA and CE on HFD-induced diabetes., (Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.)