1. Fluorometric determination of bopindolol and celiprolol in pharmaceutical preparations and biological fluids.
- Author
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Belal F, Sharaf El-Din M, Aly F, Hefnawy M, and El-Awady M
- Subjects
- Celiprolol blood, Celiprolol urine, Drug Compounding, Humans, Limit of Detection, Linear Models, Pindolol analysis, Pindolol blood, Pindolol urine, Solvents chemistry, Celiprolol analysis, Fluorometry methods, Pindolol analogs & derivatives
- Abstract
Two sensitive fluorometric methods were developed for the determination of both bopindolol malonate (BOP) and celiprolol HCl (CLP) based on measuring their native fluorescence in methanol and acetonitrile, respectively. For BOP, the fluorescence was measured at 316 nm after excitation at 278 nm. The proposed method was successfully applied to the assay of commercial tablets as well as content uniformity testing. For CLP, the fluorescence was enhanced by the addition of carboxymethylcellulose solution and measured at 455 nm after excitation at 339 nm. The method was successfully applied to the analysis of CLP in tablets and biological fluids. In both methods, interference likely to be introduced from co-formulated, co-administered, or chemically related drugs was studied. The results were statistically compared with those obtained by reference methods and were found to be in good agreement.
- Published
- 2012
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