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The gradually progressive solitary cystic‐solid mass of chest CT scans is highly suggestive of lung cancer. We report a case of a 29‐year‐old woman with a persistent cystic‐solid lesion in the right upper lobe. A chest CT scan showed a 35 mm × 44 mm × 51 mm focal cystic‐solid mass in the anterior segment of the right upper lobe. The size of lesion had increased over 3 years, especially for the solid component. The right upper lobe pneumonectomy was performed. Postoperative pathological examination showed placental transmogrification of the lung, which is a rare cause of pulmonary cystic lesion. [ABSTRACT FROM AUTHOR]