1. N 6 -methyladenosine modification underlies messenger RNA metabolism and plant development.
- Author
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Shao Y, Wong CE, Shen L, and Yu H
- Subjects
- Methyltransferases genetics, RNA, Messenger genetics, Adenosine analogs & derivatives, Plant Development genetics
- Abstract
RNA modifications constitute an essential layer of gene regulation in living organisms. As the most prevalent internal modification on eukaryotic mRNAs, N
6 -methyladenosine (m6 A) exists in many plant species and requires the evolutionarily conserved methyltransferases, demethylases, and m6 A binding proteins for writing, erasing, and reading m6 A, respectively. In plants, m6 A affects many aspects of mRNA metabolism, including alternative polyadenylation, secondary structure, translation, and decay, which underlies various plant developmental processes and stress responses. Here, we discuss the recent progress in understanding the roles of m6 A modification in mRNA metabolism and their mechanistic link with plant development and stress responses. We also highlight some outstanding questions and provide an outlook on future prospects of m6 A research in plants., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Ltd. All rights reserved.)- Published
- 2021
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