1. Phytochemical Information and Biological Activities of Quinolizidine Alkaloids in Sophora: A Comprehensive Review.
- Author
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Wang H, Xia C, Chen L, Zhao J, Tao W, Zhang X, Wang J, Gao X, Yong J, and Duan JA
- Subjects
- Alkaloids isolation & purification, Alkaloids standards, Alkaloids therapeutic use, Analgesics isolation & purification, Analgesics pharmacology, Analgesics therapeutic use, Anti-Infective Agents isolation & purification, Anti-Infective Agents pharmacology, Anti-Infective Agents therapeutic use, Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Antimetabolites isolation & purification, Antimetabolites pharmacology, Antimetabolites therapeutic use, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacology, Antineoplastic Agents standards, Antineoplastic Agents therapeutic use, Cardiovascular Agents isolation & purification, Cardiovascular Agents pharmacology, Cardiovascular Agents therapeutic use, Drug Development, Drug Discovery, Humans, Insecticides, Plant Extracts isolation & purification, Plant Extracts standards, Plant Extracts therapeutic use, Quality Control, Quinolizidines isolation & purification, Quinolizidines standards, Quinolizidines therapeutic use, Alkaloids pharmacology, Plant Extracts pharmacology, Quinolizidines pharmacology, Sophora chemistry
- Abstract
Quinolizidine alkaloids, a main form of alkaloids found in the genus Sophora, have been shown to have many pharmacological effects. This review aims to summarize the photochemical reports and biological activities of quinolizidine alkaloids in Sophora. The collected information suggested that a total of 99 quinolizidine alkaloids were isolated and detected from different parts of Sophora plants, represented by lupinine-type, cytisine-type, sparteine-type, and matrine-type. However, quality control needs to be monitored because it could provide basic information for the reasonable and efficient use of quinolizidine alkaloids as medicines and raw materials. The nonmedicinal parts may be promising to be used as a source of quinolizidine alkaloid raw materials and to reduce the waste of resources and environmental pollution. In addition, the diversity of chemical compounds based on the alkaloid scaffold to make a biological compound library needs to be extended, which may reduce toxicity and find new bioactivities of quinolizidine alkaloids. The bioactivities most reported are in the fields of antitumor activity along with the effects on the cardiovascular system. However, those studies rely on theoretical research, and novel drugs based on quinolizidine alkaloids are expected., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2019
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