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Your search keyword '"Borovskaia TG"' showing total 3 results
Start Over Author "Borovskaia TG" Topic plants, medicinal
3 results on '"Borovskaia TG"'

1. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap].

Author

Razina TG, Udintsev SN, Tiutrin II, Borovskaia TG, and Iaremenko KV

Subjects
Animals, Drug Evaluation, Preclinical, Lymphatic Metastasis, Lymphoma, Non-Hodgkin blood, Lymphoma, Non-Hodgkin drug therapy, Male, Neoplasm Transplantation, Plant Extracts therapeutic use, Rats, Rats, Inbred Strains, Antineoplastic Agents, Phytogenic therapeutic use, Phytotherapy, Plants, Medicinal, Platelet Aggregation drug effects
Abstract

The advancement of Pliss' lymphosarcoma in rats was shown to be associated with disorders of platelet-mediated hemostasis presenting with either lowered or increased aggregation activity of platelets. In the latter case, a direct correlation was observed between functional activity of thrombocytes, on the one hand, and degree of tumor advancement and its metastatic activity, on the other. Extract of Scutellaria baicalensis Georgi was shown to produce a normalizing effect on platelet-mediated hemostasis whatever the pattern of alteration which points to the adaptogenic activity of the drug. This activity is thought to be responsible for the drug's antitumor and, particularly, metastasis-preventing effect.

Published
1989

2. [A decrease in the toxic action of rubomycin on the small intestine of mice with a transplantable tumor through the use of a Rhodiola extract].

Author

Borovskaia TG, Fomina TI, and Iaremenko KV

Subjects
Animals, Daunorubicin therapeutic use, Drug Evaluation, Preclinical, Drug Interactions, Epithelium drug effects, Epithelium pathology, Intestinal Mucosa drug effects, Intestinal Mucosa pathology, Intestine, Small pathology, Male, Mice, Neoplasm Transplantation, Carcinoma, Ehrlich Tumor drug therapy, Daunorubicin toxicity, Intestine, Small drug effects, Plant Extracts therapeutic use, Plants, Medicinal
Published
1988

3. [Dilution of the toxic action of 5-fluorouracil on the mucosa of the small intestine in mice using the sap of plantain].

Author

Borovskaia TG, Udintsev SN, Zueva EP, Fomina TI, and Neĭshtadt EL

Subjects
Animals, Carcinoma, Ehrlich Tumor drug therapy, Carcinoma, Ehrlich Tumor pathology, Drug Evaluation, Preclinical, Drug Interactions, Fluorouracil therapeutic use, Intestinal Mucosa pathology, Jejunum pathology, Male, Mice, Mitosis drug effects, Neoplasm Transplantation, Plant Extracts therapeutic use, Time Factors, Fluorouracil toxicity, Intestinal Mucosa drug effects, Jejunum drug effects, Plant Extracts pharmacology, Plantago, Plants, Medicinal
Abstract

The study was concerned with an attempt at reducing the acute toxic effect of 5-fluorouracil (5-FU) on gut mucosa in mice with Ehrlich ascites tumors. An official preparation of plantain sap was shown to ward off this effect and to contribute to the normalising of certain parameters of epithelial cells. The DNA level of tumor cells showed a more drastic decline after combined treatment with 5-FU and the preparation than after the cytostatic drug alone.

Published
1987

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