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Purpose: Pedalium murex is a fruit-bearing annual herb, native to South India, Mexico and tropical Africa. The plant is widely used to treat numerous diseases including gastric ulcer, asthma, heart problems, anti inflammatory activity and particularly urinary disorders. Traditional medicine has become a skilled approach by means of rational values in handling a variety of diseases and developing an affordable phytotherapy. It is proclaimed that P.murex is an expensive source of unique bioactive compounds for the development of natural medicines against various diseases., Conclusion: This review provides the details of ethno pharmacological importance of P. murex, as well as its composition of phytochemicals, biological activities and traditional usage. Also provides a source for future studies such as isolation of bioactive components and mechanism of action of this plant extract., (Copyright © 2018 Elsevier Masson SAS. All rights reserved.)

Bada Gokhru (Pedalium murex L.) is perhaps the most useful traditional medicinal plant in India. Each part of the neem tree has some medicinal property and is thus commercially exploitable. During the last five decades, apart from the chemistry of the Pedalium murex compounds, considerable progress has been achieved regarding the biological activity and medicinal applications of this plant. It is now considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products. This review gives a bird's eye view mainly on the biological activities of some of this compounds isolated, pharmacological actions of the extracts, clinical studies and plausible medicinal applications of gokharu along with their safety evaluation.