1. Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma.
- Author
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Kyrtsonis, Marie-Christine, Vassilakopoulos, Theodoros P., Kafasi, Nicoletta, Sachanas, Sotirios, Tzenou, Tatiana, Papadogiannis, Argiroula, Galanis, Zacharoula, Kalpadakis, Christina, Dimou, Maria, Kyriakou, Elias, Angelopoulou, Maria K., Dimopoulou, Maria N., Siakantaris, Marina P., Dimitriadou, Evangelia M., Kokoris, Styliani I., Panayiotidis, Panayiotis, and Pangalis, Gerassimos A.
- Subjects
MULTIPLE myeloma ,PROGNOSIS ,DEHYDROGENASES ,BONE marrow ,PLASMA cell diseases ,DRUG therapy - Abstract
The prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as κ/ λ or λ/ κ, depending on the patients’ dominating monoclonal light chain. Median baseline sFLCR was 3·57 in κ-MM patients, 45·09 in λ-MM. ‘High’ sFLCR (≥ the observed median value for κ- and λ-MM respectively) correlated with elevated serum creatinine and lactate dehydrogenase, extensive marrow infiltration and light chain type MM. The 5-year disease-specific survival was 82% and 30% in patients with sFLCR lower than and equal or greater than the median, respectively ( P = 0·0001). sFLCR was an independent prognostic factor. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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