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2 results on '"Beavers, Craig J."'

1. Obesity and Antiplatelets-Does One Size Fit All?

Author

Beavers, Craig J., Heron, Paula, Smyth, Susan S., Bain, Jonathan A., and Macaulay, Tracy E.

Subjects
*PLATELET aggregation inhibitors, *OBESITY treatment, *VASCULAR diseases, *PHARMACODYNAMICS, *BODY mass index, *PATIENTS, TREATMENT of vascular diseases
Abstract

Antiplatelet therapy has become a cornerstone in the management of many vascular diseases. With growing antiplatelet options, attention has focused on their comparative effectiveness in specific patient populations. Perhaps one of the least defined factors influencing efficacy of these agents is body mass and obesity. Evidence from preclinical models established that obesity promotes inflammation that in turn enhances platelet reactivity. Thus, adiposity has the potential to diminish or alter the therapeutic effect of antiplatelet therapy. Pharmacodynamic analyses suggest a potential need for dose adjustments of antiplatelet therapy in obese patients. Yet, obese patients paradoxically have better outcomes after acute coronary syndromes. In this review, we identify a critical need for clinical studies with outcome data to enable the development of recommendations for optimal antiplatelet regimens in obese individuals. Until such data exists, healthcare providers should be aware of the potential impact of obesity on the efficacy of anti-platelet therapy. [ABSTRACT FROM AUTHOR]

Published
2015
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2. 2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease: A Report of the American College of Cardiology Solution Set Oversight Committee.

Author

Kumbhani, Dharam J., Cannon, Christopher P., Beavers, Craig J., Bhatt, Deepak L., Cuker, Adam, Gluckman, Ty J., Marine, Joseph E., Mehran, Roxana, Messe, Steven R., Patel, Nimesh S., Peterson, Benjamin E., Rosenfield, Kenneth, Spinler, Sarah A., Thourani, Vinod H., and Writing Committee

Subjects
*INTERNATIONAL normalized ratio, *PERCUTANEOUS coronary intervention, *CEREBRAL embolism & thrombosis, *ATRIAL fibrillation, *THROMBOEMBOLISM, *TRANSIENT ischemic attack, *LEGISLATIVE oversight, *CARDIOVASCULAR diseases, *CARDIOVASCULAR disease treatment, *ATRIAL fibrillation treatment, *CARDIOLOGY, *VEINS, *MEDICAL care, *CARDIOVASCULAR system, *PLATELET aggregation inhibitors, *MEDICAL societies, *DISEASE complications, THROMBOEMBOLISM prevention
Abstract

This article has been temporarily removed as it was inadvertently posted ahead of an agreed-upon embargo. The article will be reinstated upon embargo expiry. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. [ABSTRACT FROM AUTHOR]

Published
2021
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