Introduction: The psychological traits of a mother, particularly her relationship with her child, have a significant impact on her lack of pleasure-seeking behaviors. Aim: This research aimed to explore the correlation between the quality of the mother-child relationship and the strategies of thought suppression and absence of pleasure-seeking in mothers of children with autism. Method: In this descriptive-correlational research, the study population comprised all mothers of children with autism in the city of Ahvaz (Iran) during 2020-2021. A sample of 200 individuals was selected using a convenience sampling technique. Data was gathered using the Pianta’s Child-Parent Interaction Questionnaire (1994), Wells and Davies’ Thought Control Questionnaire (1994), and Snaith-Hamilton Pleasure Scale (1995). Pearson correlation and regression analysis were performed SPSS version 22 and AMOS version 22 statistical software for data analysis. Results: The results indicated that all path coefficients, with the exception of social control, had significant correlations with the absence of pleasure-seeking (p=0.74, β=0.02). Furthermore, the indirect relationships between the quality of the mother-child relationship and distraction(p=0.023, β=0.175), worry(p=0.005, β=0.151), punishment(p=0.004, β=-0.178), and appraisal (p=0.026, β=0.144) were significant when mediated by the absence of pleasure-seeking. However, social control did not show a significant correlation with the quality of the mother-child relationship when mediated by the absence of pleasure-seeking (p=0.549, β=-0.017). Conclusion: The results of the study underscore the direct predictive role of distraction, worry, punishment, and appraisal in Quality of the Mother-Child, with Absence of Pleasure-Seeking an indirect role. Therefore, by controlling thoughts, we can anticipate improved performance, as well as increased pleasure-seeking behaviors in these mothers. This, in turn, is expected to improve the interaction between mothers and their children with autism. [ABSTRACT FROM AUTHOR]