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Your search keyword '"Zhou,Yingfan"' showing total 2 results
Start Over Author "Zhou,Yingfan" Topic pneumonia
2 results on '"Zhou,Yingfan"'

1. NACHT, LRR, and PYD domains-containing Protein 3 and LL-37: prognostic value of new biomarkers in community-acquired pneumonia.

Author

Zhu C, Zhou Y, Zhu J, Liu Y, and Sun M

Subjects
Aged, Biomarkers blood, Case-Control Studies, Community-Acquired Infections mortality, Female, Humans, Kaplan-Meier Estimate, Leucine-Rich Repeat Proteins, Logistic Models, Male, Middle Aged, Multivariate Analysis, Pneumonia mortality, Predictive Value of Tests, Prospective Studies, Reference Values, Risk Assessment, Risk Factors, Time Factors, Cathelicidins, Antimicrobial Cationic Peptides blood, Community-Acquired Infections blood, NLR Family, Pyrin Domain-Containing 3 Protein blood, Pneumonia blood, Proteins analysis, Pyrin blood
Abstract

Objective: This study aimed to determine the serum levels of NACHT, Leucine-rich repeat (LRR), and Pyrin (PYD) domains-containing Protein 3 (NLRP3) and cathelicidin LL-37, and investigate their prognostic significance in community-acquired pneumonia (CAP)., Methods: The sample of this prospective study was composed of 76 consecutive patients with CAP. Demographic data and clinical characteristics were collected. Serum levels of NLRP3 and LL-37 were determined by ELISA. Spearman's analysis was used to evaluate the correlation between NLRP3 and LL-37. Association of NLRP3 and LL-37 with 30-day survival and mortality rates was assessed using the Kaplan-Meier curve and logistic regression analysis., Results: Serum NLRP3 significantly increased whereas serum LL-37 significantly decreased in patients with severe CAP. Significant correlation was observed between serum NLRP3 and LL-37 in CAP patients. Patients with higher levels of NLRP3 and lower levels of LL-37 showed lower 30-day survival rate and higher mortality compared with those with lower NLRP3 and higher LL-37 levels., Conclusion: Severe CAP patients tend to present higher serum NLRP3 and lower serum LL-37, which might serve as potential biomarkers for CAP prognosis.

Published
2019
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2. Proteína 3 contendo um domínio NACHT, porção C-terminal rica em repetições de leucina e de domínio pirina e LL-37: valor prognóstico de novos biomarcadores em pneumonia adquirida na comunidade

Author

Zhu, Chuanan, Zhou, Yingfan, Zhu, Jiabin, Liu, Ye, and Sun, Mengyi

Subjects
Male, Time Factors, Community-acquired pneumonia, Prognóstico, Kaplan-Meier Estimate, Leucine-Rich Repeat Proteins, Risk Assessment, Predictive Value of Tests, Reference Values, Risk Factors, Cathelicidins, Natriuretic Peptide, Brain, NLR Family, Pyrin Domain-Containing 3 Protein, Humans, Prospective Studies, Prospective study, Aged, integumentary system, Pneumonia adquirida na comunidade, Proteins, Pneumonia, Middle Aged, Pyrin, Prognosis, Estudo prospectivo, Peptide Fragments, Community-Acquired Infections, Biomarcadores, Logistic Models, Editorial, Case-Control Studies, Multivariate Analysis, Original Article, Female, Biomarkers, Antimicrobial Cationic Peptides
Abstract

RESUMO Objetivo Este estudo teve como objetivo determinar os níveis séricos de proteína 3 contendo um domínio NACHT, porção C-terminal rica em repetições de leucina e de domínio pirina (NLRP3) e catelicidina LL-37, bem como investigar sua importância prognóstica em pneumonia adquirida na comunidade (PAC). Métodos Este estudo prospectivo incluiu 76 pacientes com PAC. Foram obtidos dados demográficos e características clínicas. Os níveis séricos de NLRP3 e LL-37 foram determinados por meio do teste ELISA. A correlação entre NLRP3 e LL-37 foi estimada por intermédio da análise de Spearman. A associação entre NLRP3 e LL-37 com 30 dias de taxa de sobrevida e de mortalidade foi avaliada pela curva de Kaplan-Meier e análise de regressão logística. Resultados Os níveis séricos de NLRP3 estavam elevados, enquanto os níveis de LL-37 apresentaram redução significativa em pacientes com PAC grave. Observou-se correlação significativa entre os níveis séricos de NLRP3 e LL-37 em pacientes com PAC. Pacientes com níveis elevados de NLRP3 e níveis reduzidos de LL-37 exibiram maior taxa de sobrevida em 30 dias e de mortalidade quando comparados com aqueles com níveis inferiores de NLRP3 e LL-37. Conclusões Pacientes com PAC grave tendem a apresentar níveis séricos elevados de NLRP3 e níveis reduzidos de LL-37, o que pode ser utilizado como um potencial biomarcador prognóstico. ABSTRACT Objective This study aimed to determine the serum levels of NACHT, Leucine-rich repeat (LRR), and Pyrin (PYD) domains-containing Protein 3 (NLRP3) and cathelicidin LL-37, and investigate their prognostic significance in community-acquired pneumonia (CAP). Methods The sample of this prospective study was composed of 76 consecutive patients with CAP. Demographic data and clinical characteristics were collected. Serum levels of NLRP3 and LL-37 were determined by ELISA. Spearman’s analysis was used to evaluate the correlation between NLRP3 and LL-37. Association of NLRP3 and LL-37 with 30-day survival and mortality rates was assessed using the Kaplan-Meier curve and logistic regression analysis. Results Serum NLRP3 significantly increased whereas serum LL-37 significantly decreased in patients with severe CAP. Significant correlation was observed between serum NLRP3 and LL-37 in CAP patients. Patients with higher levels of NLRP3 and lower levels of LL-37 showed lower 30-day survival rate and higher mortality compared with those with lower NLRP3 and higher LL-37 levels. Conclusion Severe CAP patients tend to present higher serum NLRP3 and lower serum LL-37, which might serve as potential biomarkers for CAP prognosis.

Published
2019

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