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Your search keyword '"Molnar-Kimber KL"' showing total 3 results
Start Over Author "Molnar-Kimber KL" Topic polyenes
3 results on '"Molnar-Kimber KL"'

1. Mechanism of action of rapamycin (Sirolimus, Rapamune).

Author

Molnar-Kimber KL

Subjects
Animals, Carrier Proteins metabolism, Cattle, Cell Cycle drug effects, Cell Division drug effects, Cytokines biosynthesis, DNA-Binding Proteins metabolism, Heat-Shock Proteins metabolism, Humans, Mice, Sirolimus, Tacrolimus Binding Proteins, Tumor Cells, Cultured, Antibiotics, Antineoplastic pharmacology, Immunosuppressive Agents pharmacology, Lymphocyte Activation drug effects, Polyenes pharmacology, T-Lymphocytes immunology
Published
1996

2. Comparison of effects of sirolimus on cytokine dependent and cytokine independent proliferation.

Author

Molnar-Kimber KL, Rhoad A, Warner L, Chen H, and Sehgal SN

Subjects
Animals, Carrier Proteins metabolism, Cell Division drug effects, Cell Line, DNA-Binding Proteins metabolism, Heat-Shock Proteins metabolism, Immunosuppressive Agents antagonists & inhibitors, Immunosuppressive Agents metabolism, Lymphocyte Activation drug effects, Mice, Mice, Inbred C3H, Polyenes antagonists & inhibitors, Polyenes metabolism, Sirolimus, T-Lymphocytes drug effects, Tacrolimus Binding Proteins, Cytokines physiology, Immunosuppressive Agents pharmacology, Polyenes pharmacology
Published
1995
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3. A putative sirolimus (rapamycin) effector protein.

Author

Chen Y, Chen H, Rhoad AE, Warner L, Caggiano TJ, Failli A, Zhang H, Hsiao CL, Nakanishi K, and Molnar-Kimber KL

Subjects
B-Lymphocytes metabolism, Base Sequence, Carrier Proteins isolation & purification, Cell Line, Cells, Cultured, Chromatography, Affinity, DNA Primers, Glutathione Transferase isolation & purification, Heat-Shock Proteins isolation & purification, Humans, Molecular Sequence Data, Molecular Weight, Polymerase Chain Reaction, Recombinant Fusion Proteins isolation & purification, Recombinant Proteins isolation & purification, Recombinant Proteins metabolism, Sirolimus, Tacrolimus Binding Proteins, Tumor Cells, Cultured, Carrier Proteins metabolism, Heat-Shock Proteins metabolism, Immunosuppressive Agents metabolism, Polyenes metabolism, T-Lymphocytes metabolism, Tacrolimus metabolism
Abstract

Sirolimus (rapamycin), a new immunosuppressive drug, inhibits proliferation of a wide spectrum of T and B cells. The immunosuppressive mechanism of sirolimus is still unclear. We recently isolated a membrane associated protein with an apparent molecular weight of 210 kDa, p210, from cultured Molt 4 cells and BJAB cells and from normal human T cells using an affinity matrix method. The p210 binds to sirolimus:FKBP12 complex, but only at background levels to FKBP12 alone, to FK506:FKBP12 complex, or sirolimus-biotin alone. Among the sirolimus analogs tested, the binding ability of p210 to drug:FKBP12 complexes correlates with the immunosuppressive activity of the drugs, suggesting that p210 is the sirolimus effector protein.

Published
1994
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