1. Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies.
- Author
-
Sheikhi M, Nemayandeh N, and Shirangi M
- Subjects
- Polylactic Acid-Polyglycolic Acid Copolymer, Lactic Acid, Peptides, Acylation, Polyesters, Polyglycolic Acid
- Abstract
Biodegradable polyesters are widely employed in the development of controlled release systems for peptide drugs. However, one of the challenges in developing a polyester-based delivery system for peptides is the acylation reaction between peptides and polymers. Peptide acylation is an important factor that affects formulation stability and can occur during storage, in vitro release, and after drug administration. This review focuses on the mechanisms and parameters that influence the rate of peptide acylation within polyesters. Furthermore, it discusses reported strategies to minimize the acylation reaction., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
- Full Text
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