1. Low band gap donor-acceptor conjugated polymer nanoparticles and their NIR-mediated thermal ablation of cancer cells.
- Author
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MacNeill CM, Coffin RC, Carroll DL, and Levi-Polyachenko NH
- Subjects
- Azoles chemistry, Cell Survival drug effects, Colorectal Neoplasms drug therapy, Humans, Organoselenium Compounds chemistry, Polymers chemistry, Thiadiazoles chemistry, Thiophenes chemistry, Hot Temperature, Hyperthermia, Induced methods, Infrared Rays, Nanoparticles therapeutic use, Neoplasms drug therapy, Polymers therapeutic use, Thiadiazoles therapeutic use
- Abstract
Low band gap D-A conjugated PNs consisting of 2-ethylhexyl cyclopentadithiophene co-polymerized with 2,1,3-benzothiadiazole (for nano-PCPDTBT) or 2,1,3-benzoselenadiazole (for nano-PCPDTBSe) have been developed. The PNs are stable in aqueous media and showed no significant toxicity up to 1 mg · mL(-1) . Upon exposure to 808 nm light, the PNs generated temperatures above 50 °C. Photothermal ablation studies of the PNs with RKO and HCT116 colorectal cancer cells were performed. At concentrations above 100 µg · mL(-1) for nano-PCPDTBSe, cell viability was less than 20%, while at concentrations above 62 µg · mL(-1) for nano-PCPDTBT, cell viability was less than 10%. The results of this work demonstrate that low band gap D-A conjugated polymers 1) can be formed into nanoparticles that are stable in aqueous media; 2) are non-toxic until stimulated by IR light and 3) have a high photothermal efficiency., (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2013
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