The genetic patterns of 25 populations from seven ethnic groups living in the Ural region (Komi, Komi-Permyaks, Udmurts, Mansi, Nentsy, Tatars, and Chuvashes) were studied. Immunological, biochemical, and physiological markers of the loci ABO, FUT, RH, P, FY, DI, KEL, LU, LE, JK, HP, GC, C'3, TF, PI, ACP1, GLO1, ESD, PGD, PGM1, PTC, and CB were studied. The average ethnic frequencies of the alleles and haplotypes studied were estimated. It was demonstrated that the Ural populations living to the west of the Urals, although of different origin, were more similar genetically than populations of common (Ural) origin living on different sides of the Urals, with respect to the majority of the traits studied.