6 results on '"Yashin, Yakov"'
Search Results
2. Antioxidant Activity of Spices and Their Impact on Human Health: A Review.
- Author
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Yashin, Alexander, Yashin, Yakov, Xiaoyan Xia, and Nemzer, Boris
- Subjects
ANTIOXIDANTS ,SPICES ,FREE radicals ,NEUTRALIZATION (Chemistry) ,FOOD color ,THERAPEUTICS - Abstract
Antioxidants are substances that prevent oxidation of other compounds or neutralize free radicals. Spices and herbs are rich sources of antioxidants. They have been used in food and beverages to enhance flavor, aroma and color. Due to their excellent antioxidant activity, spices and herbs have also been used to treat some diseases. In this review article, the chemical composition and antioxidant activity of spices and culinary herbs are presented. The content of flavonoids and total polyphenols in different spices and herbs are summarized. The applications of spices and their impacts on human health are briefly described. The extraction and analytical methods for determination of antioxidant capacity are concisely reviewed. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
3. Antioxidant activity of polyphenols from larch wood: an amperometric study.
- Author
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Yashin, Alexander Y., Yashunsky, Dmitry V., Vedenin, Aleksander N., Nifantiev, Nikolay E., Yashin, Yakov I., and Nemzer, Boris V.
- Subjects
POLYPHENOLS ,ANTIOXIDANTS ,REACTIVE oxygen species ,LIPID peroxidation (Biology) ,PHOSPHORIC acid ,CONDUCTOMETRIC analysis - Abstract
Purpose The purpose of this paper is to determine the antioxidant activity of natural polyphenols from larch wood by the amperometric method.Design/methodology/approach Direct measurements of antioxidant activity were carried out by the amperometric method in an oxidizing mode with glassy carbon as a working electrode, set potential +1.3V and using a flow-injection system with 2.2 mM phosphoric acid as the mobile phase with a flow rate of 1.2 ml/min.Findings The reported results show the following values of antioxidant activity for the tested compounds: (−)-secoisolariciresinol – 0.199 ± 0.002 mg/L (p < 0.05); isolariciresinol – 0.196 ± 0.002 mg/L (p < 0.05); lariciresinol - 0.222 ± 0.001 mg/L (p < 0.05); O-isopropylidene derivative of (−)-secoisolariciresinol - 0.143 ± 0.002 mg/L (p < 0.05); (+)-dihydroquercetin – 0.153 ± 0.002 mg/L (p < 0.05); and quercetin – 0.521 ± 0.001 mg/L (p < 0.05). The last product was tested as the reference of a widely used current antioxidant. General tendencies of determined values of antioxidant activity for studied compounds are in good correlation with published data as determined by the t-BuOOH-initiated lipid peroxidation method.Practical implications Described results show practical applicability of the amperometric method as being faster and cheaper in comparison to other methods, including oxygen radical absorbance capacity (ORAC) assay or 2,2′diphenyl-1-picrylhydrazyl (DPPH) reagent based assay.Originality/value The described results show the first-time application of the amperometric method for the evaluation of the antioxidant activity of phenolic compounds from larch wood. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
4. Beneficial Effect of Tea on Human Health.
- Author
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Yashin, Aleksander, Yashin, Yakov, and Nemzer, Boris
- Subjects
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TEA , *CARDIOVASCULAR disease treatment , *TREATMENT of neurodegeneration , *PHYTOTHERAPY , *DIETARY supplements , *THERAPEUTICS ,PHYSIOLOGICAL effect - Abstract
Tea, with its 5,000-year history, is one of the most popular beverages in the world. According to various estimates, over 4 billion people consume tea. This number has increased in recent years due to the widespread marketing of cold tea-based beverages. During the first millennium tea was primarily considered to be medicine rather than an ordinary drink. Over the last few years a large number of epidemiological studies have conclusively proven that tea is beneficial for people with cardiovascular and neurodegenerative diseases, and cancers. Tea catechins are included in numerous dietary supplements and medicinal products. This review summarizes scientific information related to the effects of tea on human health which have been published in the last decade. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
5. The Issues of Antioxidant Therapy.
- Author
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Nemzer, Boris V., Yashin, Alexander Y., and Yashin, Yakov I.
- Subjects
THERAPEUTIC use of antioxidants ,CHEMICAL inhibitors ,OXIDATIVE stress ,OXIDATION-reduction reaction ,FREE radicals - Abstract
Interest in antioxidants and antioxidant therapy has been growing during the last decade. Antioxidants are generally considered to have the capability to protect people from harmful effects of reactive oxygen and nitrogen species (RONSs), including free radicals (FR), when these are present in excessive amounts. RONS and free radicals perform a variety of useful biological functions in the body. Their excess is controlled by a natural antioxidant protection system in humans. This protection is provided at three levels: by simple molecules (such as cysteine, glutathione (GSH), uric acid, ubiquinol, etc.), medium-molecular weight, and high molecular weight compounds (enzymes, etc.). Under certain adverse conditions, this system does not manage to provide adequate protection and the RONSs and free radicals begin to damage vital DNA, proteins, and lipids. In such a case, antioxidant therapy, which includes antioxidant supplements and foods containing natural antioxidants, has been suggested to be of possible benefit. However, there are many unresolved issues related to the effective use of an antioxidant therapy: 1. A person should know the content of antioxidants in everyday food products and its relation to the storage time and processing methods used. 2. How many antioxidants should a person consume? It is known that at high concentrations some antioxidants become pro-oxidants. 3. Are the antioxidants consumed by a person bioavailable and, if so, to what extent; for some food products, bioavailability has already been determined but most foods have not been examined. 4. Many antioxidants are digested by intestinal microflora before they reach the systemic blood circulation. 5. Even those antioxidants that do reach the blood are often rapidly metabolized; the role of their metabolites is unclear; there is some evidence that certain metabolites are also antioxidants. 6. How long do antioxidants and their metabolites stay in the body; how are they distributed in different organs; and when are they excreted? In order to answer these questions, the pharmacokinetics of antioxidants should be studied. 7. The presence of oxidative stress, i.e., excess amounts of RONSs and free radicals, can be detected by various oxidative stress markers but, in order to see the whole picture, the actual concentrations of RONSs and free radicals should also be monitored. In vivo determination of RONSs and free radicals is almost never conducted. All these questions must be addressed in order to provide appropriate antioxidant therapy. This could be extremely important because it could be used to detect and even prevent diseases at early stages of development. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
6. Cranberry: Chemical Composition, Antioxidant Activity and Impact on Human Health: Overview.
- Author
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Nemzer, Boris V., Al-Taher, Fadwa, Yashin, Alexander, Revelsky, Igor, and Yashin, Yakov
- Subjects
CRANBERRIES ,BIOACTIVE compounds ,PROANTHOCYANIDINS ,PLANT polyphenols ,GASTRIC diseases ,VACCINIUM ,TYPE 2 diabetes ,FUNCTIONAL foods - Abstract
Cranberries are a rich source of bioactive compounds that comprise a healthy diet. Cranberry is abundant in nutritional components and many bioactive compounds that have antioxidant properties. Both American (Vaccinium macrocarpon) and European (Vaccinium oxycoccus) cranberry species are rich in polyphenols such as phenolic acids, anthocyanins and flavonoids, and is one of the few fruits that is high in proanthocyanidins, which is linked to many health benefits. The review systematizes information on the chemical composition of cranberry, its antioxidant effect, and the beneficial impact on human health and disease prevention after cranberry consumption, and in particular, its effect against urinary tract inflammation with both adults and children, cardiovascular, oncology diseases, type 2 diabetes, metabolic syndrome, obesity, tooth decay and periodontitis, Helicobacter pylori bacteria in the stomach and other diseases. Additional research needs to study cranberry proteomics profiling, polyphenols interaction and synergism with other biologically active compounds from natural ingredients and what is important in formulation of new functional foods and supplements. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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