1. Chemically modified polysaccharides: Synthesis, characterization, structure activity relationships of action.
- Author
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Xu, Yong, Wu, Yu-ji, Sun, Pei-long, Zhang, Fu-ming, Linhardt, Robert J., and Zhang, An-qiang
- Subjects
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POLYSACCHARIDES , *STRUCTURE-activity relationships , *POLYSACCHARIDE synthesis , *CHEMICAL structure - Abstract
Polysaccharides are a major class of biomacromolecules. Their bioactivities depend on chemical structure, which includes monosaccharide composition, linkages below sugar residues, and solution conformation. Many researchers report that chemical modifications of polysaccharides lead to a significantly increase in the structural diversity, promoting bioactivity and even add new bioactivities, including antioxidant and anti-tumor properties as well as anticoagulant and immunoregulatory activities. This paper reviews the recent progress of chemical modification of polysaccharides, including i) the common synthetic methods of chemical modification; ii) their structural characterization; iii) their bioactivities; and iv) the structure activity relationships of these modified polysaccharides. This review also suggests future directions for researchers and new applications for chemically modified polysaccharide derivatives in the pharmaceutical and food industries. • Chemically modified polysaccharides of the past two decades of online review research. • These generalizations are better for people to understand the research status of chemical modified polysaccharides. • This review suggests future directions and new applications for researchers and in the pharmaceutical and food industries. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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