1. Isolation and synthesis of a new benzylated alkamide from the roots of Lepidium meyenii .
- Author
-
Ye YQ, Ma ZH, Yang QF, Sun YQ, Zhang RQ, Wu RF, Ren X, Mu LJ, Jiang ZY, and Zhou M
- Subjects
- Antineoplastic Agents, Phytogenic chemical synthesis, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Benzyl Compounds chemistry, Benzyl Compounds pharmacology, Cell Line, Tumor, China, Drug Screening Assays, Antitumor, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Plant Roots chemistry, Polyunsaturated Alkamides chemistry, Polyunsaturated Alkamides pharmacology, Benzyl Compounds isolation & purification, Lepidium chemistry, Polyunsaturated Alkamides isolation & purification
- Abstract
A new benzylated alkamide, N -(3,4-dimethoxybenzyl)-9 Z -oleamide ( 1 ), along with two known ones ( 2 and 3 ) were isolated from the roots of Lepidium meyenii collected from Lijiang, Yunnan Province of China. Their structures were elucidated by extensive spectroscopic analyses and the new compound further confirmed by a one-step synthesis. All the isolated alkamides were evaluated for their cytotoxicity against five human cancer cell lines. However, no significant activities were detected at concentrations up to 40 μ M.
- Published
- 2019
- Full Text
- View/download PDF