1. Effects of Sodium Tripolyphosphate on Oral Commensal and Pathogenic Bacteria.
- Author
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Moon JH, Noh MH, Jang EY, Yang SB, Kang SW, Kwack KH, Ryu JI, and Lee JY
- Subjects
- Dental Plaque microbiology, Humans, Microbial Sensitivity Tests, Mouth microbiology, Periodontitis microbiology, Periodontitis prevention & control, Streptococcus gordonii drug effects, Anti-Bacterial Agents pharmacology, Biofilms drug effects, Dental Plaque drug therapy, Fusobacterium nucleatum drug effects, Periodontitis drug therapy, Polyphosphates pharmacology, Porphyromonas gingivalis drug effects, Prevotella intermedia drug effects
- Abstract
Polyphosphate (polyP) is a food additive with antimicrobial activity. Here we evaluated the effects of sodium tripolyphosphate (polyP3, Na
5 P3 O10 ) on four major oral bacterial species, in both single- and mixed-culture. PolyP3 inhibited three opportunistic pathogenic species: Fusobacterium nucleatum, Prevotella intermedia , and Porphyromonas gingivalis . On the contrary, a commensal bacterium Streptococcus gordonii was relatively less susceptible to polyP3 than the pathogens. When all bacterial species were co-cultured, polyP3 (≥ 0.09%) significantly reduced their total growth and biofilm formation, among which the three pathogenic bacteria were selectively inhibited. Collectively, polyP3 may be an alternative antibacterial agent to control oral pathogenic bacteria., Polyphosphate (polyP) is a food additive with antimicrobial activity. Here we evaluated the effects of sodium tripolyphosphate (polyP3, Na5 P3 O10 ) on four major oral bacterial species, in both single- and mixed-culture. PolyP3 inhibited three opportunistic pathogenic species: Fusobacterium nucleatum, Prevotella intermedia , and Porphyromonas gingivalis . On the contrary, a commensal bacterium Streptococcus gordonii was relatively less susceptible to polyP3 than the pathogens. When all bacterial species were co-cultured, polyP3 (≥ 0.09%) significantly reduced their total growth and biofilm formation, among which the three pathogenic bacteria were selectively inhibited. Collectively, polyP3 may be an alternative antibacterial agent to control oral pathogenic bacteria.- Published
- 2019
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