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A recent report from the University of Coimbra in Portugal discusses a novel strategy for enhancing antibody-dependent cellular cytotoxicity against triple-negative breast cancer. The study focuses on the development of antibodies targeting nucleolin, a promising immunotherapeutic target for this aggressive subtype of breast cancer. Researchers successfully identified antibodies with increased binding affinity and improved cytotoxic activity against triple-negative breast cancer cells, highlighting the potential of this approach for future immunotherapeutic interventions. The research was supported by various funding sources and has been peer-reviewed for publication in the Biotechnology Journal. [Extracted from the article]

A study conducted at the University of Coimbra in Portugal explored the effectiveness of a new intervention called STOP Procrastination, based on acceptance and compassion principles, in addressing procrastination among higher education students. The 10-session group intervention led to improvements in procrastination and emotional regulation processes, with participants reporting the intervention as acceptable and beneficial. While the study is preliminary, the results are promising, suggesting the need for further research to evaluate the efficacy of STOP Procrastination in educational settings. [Extracted from the article]

A systematic review conducted by investigators at Polytechnical University in Coimbra, Portugal, explored the potential role of immunotherapy in treating penile cancer (PeCa). The research highlighted the challenges in patient recruitment for clinical trials due to the rarity of the disease, stigma associated with PeCa, and patient preferences for quicker treatment options. While only one study met the inclusion criteria, showing a 6% objective response rate across nineteen patients with different tumor histologies, further observation is needed as other studies are ongoing or recruiting. This peer-reviewed research provides valuable insights into the potential of immunotherapy in the context of PeCa treatment. [Extracted from the article]

A recent study conducted at the University of Coimbra in Portugal utilized a three-dimensional computational model to investigate the development and progression of diffuse gastric cancer. The research focused on the role of cell adhesion and proliferation in tumor formation, highlighting the potential of computational models in understanding gastric cancer mechanisms for future therapeutic interventions. This study was supported by Fundacao para a Ciencia e a Tecnologia (FCT) and was published in the Bulletin of Mathematical Biology. For more information, readers can contact the University of Coimbra directly. [Extracted from the article]

A recent study conducted at the University of Coimbra in Portugal examined the impact of guided tours on the welfare of white-handed gibbons and capuchin monkeys at Maia Zoo. The research aimed to assess how visitor behavior influenced the behavior of the primates and whether guided tours helped regulate unwanted noise and behavior. Results showed that guided tours were associated with lower noise levels and reduced self-grooming frequencies in gibbons, while capuchin monkeys exhibited similar responses between tour types. The study suggests that integrating guided tours as educational and conservation initiatives could engage visitors and potentially enhance zoo animal welfare. [Extracted from the article]

Researchers at the University of Coimbra in Portugal have conducted a study on the synthesis, structural, and mechanical properties of alumina-yttria-stabilized zirconia nanocomposites for potential use in dental ceramics. The study found that adding alumina to yttria-tetragonal-stabilized zirconia composites improved their mechanical strength and toughness, making them suitable for dental applications. The research, funded by various organizations, concluded that these nanocomposites maintained their toughness and mechanical properties even under accelerated degradation conditions. For more information, readers can refer to the article "Synthesis, Structural, and Mechanical Properties of Alumina-yttria-stabilized Zirconia Nanocomposites for Prospective Dental Ceramics" published in Advanced Engineering Materials. [Extracted from the article]

Researchers from the University of Coimbra in Portugal have conducted a study on rectal cancer, focusing on predictive biomarkers for tumor response to neoadjuvant chemoradiotherapy. The research highlights the importance of molecular pathways in selecting potential biomarkers, with some showing promise in predicting response to treatment. Key indicators include MRI evaluations, tumor regression grades, and potentially circulating tumor DNA from liquid biopsies. This study sheds light on the distinct molecular and biological characteristics of rectal cancer, emphasizing the need for personalized approaches in oncology. [Extracted from the article]

A recent study conducted at the University of Coimbra in Portugal focused on the impact of particle size on drug substances and dosage forms, particularly in the context of a complex topical drug product assessment. The researchers developed an Analytical Quality by Design (AQbD) approach to assess particle size using automated microscopy and laser light diffraction, along with Raman spectroscopy for chemical composition analysis. The study concluded that a trade-off between techniques is necessary for particle size design, with laser light diffraction offering higher throughput and precision, while automated microscopy provides more reliable information on size and shape analysis. The validated methods successfully demonstrated the implementation of an AQbD method in defining particle size methods. [Extracted from the article]

A study conducted in Coimbra, Portugal, focused on evaluating emotional distress in cancer patients receiving palliative care. The research analyzed the psychometric properties of the Edmonton Symptom Assessment System (ESAS) and the Palliative Outcome Scale (POS) among hospitalized cancer patients. Findings indicated strong correlations between anxiety, self-reported symptoms, emotional sharing, perceived meaning of life, understanding the importance of life, and depressive symptoms. The study concluded that the ESAS and POS are practical tools for assessing emotional distress in palliative care settings. [Extracted from the article]

A recent study conducted by the University of Coimbra examined socioeconomic inequalities in the place of death for individuals over 50 in Europe. The research found that individuals with lower incomes were more likely to die at home compared to those with higher incomes, while education did not significantly impact the place of death. The study highlighted that around 34.3% of deaths in Europe occurred at home, with Bulgaria and Romania having the highest rates of home deaths, and Cyprus and Finland having the lowest. This research sheds light on the importance of understanding how socioeconomic factors can influence end-of-life care and the quality of the dying process. [Extracted from the article]

Recent research from Coimbra Hospital and University Center in Portugal has focused on the prognostic impact of acute exacerbations in patients with interstitial lung diseases. The study found that patients with idiopathic pulmonary fibrosis (IPF) had longer hospital stays compared to other fibrosing lung diseases, but there was no significant difference in mortality rates. The research suggests that IPF may have a more progressive course despite treatment with corticosteroids. This study has been peer-reviewed and provides valuable insights into the management of interstitial lung diseases. [Extracted from the article]

Researchers from the University of Coimbra in Portugal have conducted a study on the heterogeneous redox responses in NHDF cells primed to enhance mitochondrial bioenergetics. The research addresses the impact of metabolic priming on redox dynamics in cells, specifically focusing on oxidative stress responses induced by hydrogen peroxide and tert-butyl hydroperoxide. The findings suggest that enhanced mitochondrial bioenergetics lead to a constant regulation of cellular redox machinery, resulting in heterogeneous responses. The study emphasizes the importance of refining in vitro models to better reflect in vivo conditions for the development of effective redox-based therapeutic strategies. [Extracted from the article]

Researchers from the University of Coimbra in Portugal have conducted a study on liver cancer, focusing on the use of curcumin-encapsulated glucan nanoparticles to modulate oxidative stress in human hepatic cancer cells. The study found that smaller curcumin-loaded glucan nanoparticles were more effective in reducing cell viability and inducing oxidative stress in cancer cells. This research, funded by various organizations, suggests that these nanoparticles could be promising for future studies on oxidative stress-induced tumor cell death mechanisms. The study has been peer-reviewed and published in Colloids and Surfaces B-biointerfaces. [Extracted from the article]

Researchers from the Hospital & University of Coimbra conducted a systematic review and meta-analysis on the use of unfractionated heparin (UFH) pretreatment in patients with ST segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention. The study included 14 studies with a total of 76,446 patients and found that UFH pretreatment was associated with reduced all-cause mortality, lower rates of in-hospital cardiogenic shock, higher rates of spontaneous reperfusion events, and decreased major bleeding events. The research suggests that UFH pretreatment may be beneficial for patients with STEMI undergoing primary percutaneous coronary intervention. [Extracted from the article]

A study conducted at Coimbra Hospital and University Center in Portugal focused on the prevalence of Hepatitis C virus (HCV) antibodies in patients with psychiatric conditions and substance use disorders. The research found that 17.4% of patients tested positive for HCV antibodies, with 7.4% having detectable HCV RNA indicating chronic hepatitis C (CHC). The study highlighted a higher prevalence of HCV antibodies and confirmed CHC in patients at the Dual Pathology Outpatient and Inpatient Unit compared to the general Portuguese population. [Extracted from the article]

A study conducted by Instituto Superior Miguel Torga in Coimbra, Portugal, focuses on developing an e-mental health tool called KindMap to support individuals dealing with infertility. The KindMap integrates mindfulness, self-compassion, and Acceptance and Commitment Therapy components to promote well-being. The study aims to evaluate the feasibility of KindMap through a randomized controlled trial and assess its impact on various psychological outcomes. This research contributes to the growing field of e-health technologies applied to mental health, with outcomes to be disseminated through publications and conference presentations. [Extracted from the article]

A study conducted by researchers from the University of Coimbra in Portugal focused on the impact of gratitude practice on well-being and mental health among Portuguese adults in the post-COVID era. The study involved 63 participants who engaged in weekly gratitude tasks, showing improvements in life satisfaction, positive affect, compassion for others, and post-traumatic growth. The research concluded that gratitude practice can decrease psychological disturbance and enhance psychological well-being, but further studies are needed to confirm these findings. The study was peer-reviewed and can be accessed through Current Psychology. [Extracted from the article]

A recent study conducted at the University of Coimbra in Portugal examined the skeletal remains of a child from the 16th-18th century CE in Almeirim, Portugal, revealing bone features suggestive of thalassemia, a disease associated with malaria-endemic regions. The research suggests a potential link between thalassemia, past migrations, and malaria in the westernmost part of Europe. This study sheds light on the historical presence of hemoglobinopathies in the region, possibly influenced by past Islamic and sub-Saharan populations and the historical impact of malaria. [Extracted from the article]

A recent study conducted in Portuguese hospitals aimed to evaluate the management of Chronic Obstructive Pulmonary Disease (COPD) exacerbations and patient outcomes. The study included 196 patients, with the majority being male and admitted through the emergency service. Findings showed that the severity of COPD exacerbations is directly related to impaired lung function, quality of life, mortality, and health system costs. The research concluded that understanding COPD exacerbations' management in Portugal could lead to improved care and awareness among clinicians, policymakers, managers, and patients. [Extracted from the article]

A study conducted by the University of Coimbra in Portugal focuses on the use of Acceptance and Commitment Therapy (ACT) as a transdiagnostic approach to treating adolescents with Social Anxiety Disorder (SAD) and Generalized Anxiety Disorder (GAD). The research aims to explore the role of Psychological Flexibility/Inflexibility (PF/PI) in adolescents' mental health and assess the efficacy of ACT in addressing anxiety disorders. The study involves data collection from 400 community adolescents and a Randomized Controlled Trial with three groups to evaluate the impact of ACT on SAD and GAD. The findings of this research are expected to contribute valuable evidence to the understanding of human suffering and expand the application of ACT to adolescents with anxiety disorders. [Extracted from the article]

A recent report from the University of Coimbra in Portugal discusses the impact of blue light exposure from electronic devices on skin health, particularly in relation to skin photoaging. The study explores the use of nanodelivery systems to enhance the efficacy and safety of cosmetic ingredients aimed at protecting the skin from the damaging effects of blue light. The research emphasizes the importance of sustainable development in cosmetic ingredients for future clinical translation and research. For more information, readers can refer to the Journal of Drug Delivery Science and Technology. [Extracted from the article]

A study conducted at the University of Coimbra in Portugal focused on detecting keratoconus in pediatric patients with high astigmatism using Pentacam indices. The research included 312 eyes from 167 patients aged 6 to 18 years and identified specific indices that effectively distinguished between keratoconus and normal pediatric patients. The study concluded that optimal cutoff points for patients with high astigmatism differed from those for nonastigmatic children and adult populations. The findings suggest focusing on specific Pentacam indices for accurate keratoconus detection in pediatric patients with high astigmatism. [Extracted from the article]

Researchers from the University of Coimbra in Portugal conducted a study on information pathologies, specifically focusing on information technology anxiety (ITA) and information overload (IO) among undergraduate students of Information Science. The study found a low prevalence of ITA but a significant occurrence of IO, with both phenomena correlating positively with the female gender. Students aged 19-24 were less likely to exhibit ITA and IO, while those aged 22 were most likely to experience both. The research highlights the need for improved skills in managing the human-information-technology relationship, particularly in information filtering and management. [Extracted from the article]

A report from Centro Hospitalar e Universitario de Coimbra in Portugal discusses the management of neonatal abstinence syndrome (NAS) using a qualitative assessment approach. The study compared this approach with the Eat, Sleep, Console (ESC) method and found a significant reduction in the use of drug therapy. The research showed a decrease in the incidence rate of NAS over the study period, highlighting the effectiveness of the qualitative assessment in identifying at-risk neonates. [Extracted from the article]

Recent research from the University of Coimbra in Portugal explores the role of ENPP1 in inducing blood-brain barrier dysfunction and promoting brain metastasis in HER2+ breast cancer patients. The study highlights how tumor cells use ENPP1 signaling to cross the blood-brain barrier and colonize the brain, impacting overall survival. This research suggests ENPP1 as a potential biomarker for early detection and poor prognosis in brain metastasis of HER2+ breast cancer. [Extracted from the article]

Researchers at the University of Coimbra in Portugal conducted a Phase 3 study on the efficacy and safety of a proposed biosimilar aflibercept (SOK583A1; Sandoz) in patients with neovascular age-related macular degeneration. The study confirmed that the biosimilar was clinically equivalent to the reference biologic in treatment outcomes, with comparable visual and anatomical results. The research, supported by Hexal AG, concluded that the proposed biosimilar aflibercept matched the reference aflibercept in efficacy, safety, and pharmacokinetics, establishing biosimilarity between the two treatments. [Extracted from the article]

A recent study conducted by researchers at the University of Coimbra in Portugal focused on remote delivered cognitive rehabilitation programs (r-CRP) for patients with acquired brain injuries (ABI). The systematic review of 19 studies found that r-CRP, primarily delivered through information and communication technologies, showed mixed results in improving cognitive and noncognitive outcomes for ABI patients. The research highlighted the need for further studies to enhance the methodological quality of clinical research on r-CRP. For more information, readers can refer to the article "Remote Delivered Cognitive Rehabilitation Programs In Acquired Brain Injury: a Systematic Review of Methods and Outcomes" published in Current Psychology. [Extracted from the article]

Researchers from the University of Coimbra in Portugal have focused on sustainable development by exploring the use of solar-powered cold storage systems to empower off-grid communities in developing countries. These systems aim to address challenges related to food insecurity, lack of access to electricity, and inadequate storage for medicines and vaccines. The research highlights the potential of solar off-grid cold storage to bring sustainable development and economic growth to low-income populations, particularly in rural areas, while also contributing to the United Nations' sustainable development goals. The study provides insights into affordable business models and key challenges for deploying these systems, offering a guide for policymakers, investors, and stakeholders involved in sustainable development and off-grid electrification in developing countries. [Extracted from the article]

A study conducted by the University of Coimbra in Portugal focused on dermatophytoses, infectious skin diseases prevalent among school-age children in Cape Verde. The research found Trichophyton soudanense to be the predominant species causing dermatophytoses in this population. The study highlights the importance of accurate identification methodologies in gathering epidemiological data on dermatophytoses. This research was supported by various organizations, including the European Regional Development Fund and the FCT-Foundation for Science and Technology. [Extracted from the article]

A recent study conducted at the University of Coimbra in Portugal explored the impact of early memories of warmth and safeness (EMWS) and current experiences of warmth and safeness (CEWS) on depressive and anxious symptoms among adolescents in community and residential youth care settings. The research found that CEWS may have a protective role in reducing psychological distress among adolescents, even when EMWS were poor. The study suggests that EMWS and CEWS play a significant role in adolescents' psychological well-being during this developmental stage. [Extracted from the article]

Researchers at the University of Coimbra in Portugal have explored microneedles as a potential alternative to subcutaneous insulin injections for diabetes treatment. The study reviewed various microneedle types, materials, production technologies, and their applications in pre-clinical trials. The research concluded that microneedles are a viable technology for insulin delivery, offering a less invasive option for patients. This peer-reviewed study provides valuable insights into optimizing insulin therapy using innovative technologies. [Extracted from the article]

Researchers from the Hospital & University of Coimbra conducted a cohort study of 292 lupus patients to identify predictors of flare in those attaining lupus low disease activity state (LLDAS). The study found that patients with anti-U1-ribonucleoprotein, higher SLE-DAS scores at baseline, and those on immunosuppressants were at higher risk of flares. Remission without glucocorticoids was associated with a lower risk of flares in patients with LLDAS. This research provides valuable insights into managing lupus and preventing disease flares. [Extracted from the article]

Researchers from the Hospital & University of Coimbra in Portugal conducted a study on the relationship between self-reported sleep quality and cerebrospinal fluid biomarkers in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). They found that daytime dysfunction was higher in AD patients and correlated with cognitive scores and biomarkers. The study suggests that daytime dysfunction may be an independent predictor of neurodegeneration and dementia risk. This research was supported by Santa Casa da Misericordia de Lisboa and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Instituto Superior Miguel Torga in Coimbra, Portugal, focused on psychological inflexibility in university students. The research adapted the Acceptance and Action Questionnaire-University Students (AAQ-US) to Portuguese and found a two-factor structure related to cognitive fusion and experiential avoidance. The study concluded that the Portuguese version of the AAQ-US is a reliable and valid tool for assessing context-specific psychological inflexibility in university students. For more information, readers can refer to the article "Psychological Inflexibility In University Students: the European Portuguese Version of the Acceptance and Action Questionnaire-university Students" published in Current Psychology. [Extracted from the article]

Researchers at the University of Coimbra in Portugal have developed a sugar-based polyurethane foam colorimetric sensor for detecting Escherichia coli (E. coli). The sensor, funded by various organizations, shows promise for applications in biotechnology and biomedicine, offering a non-invasive diagnostic approach. By interacting with an E. coli-specific enzyme, the sensor produces a visible blue signal, making it a potentially simple and effective solution for E. coli detection in various settings. [Extracted from the article]

A recent study conducted by the University of Coimbra in Portugal explored the psychological traits of individuals who participate in extreme sports. The research found that while extreme sports participants are often characterized by a desire for risk and abnormal personal traits, there are also many positive aspects associated with their involvement, such as organization, planning, and confidence. The study concluded that a dynamic ecological approach is needed to understand the motives, behavior, and emotions of individuals who engage in extreme sports. For more information, readers can refer to the article "Psychological traits of extreme sport participants: a scoping review" published in BMC Psychology. [Extracted from the article]

Researchers at the Unit of Ophthalmology in Coimbra, Portugal have expanded the understanding of Fhonda Syndrome, a rare recessively inherited syndrome. The syndrome is associated with biallelic disease-causing variants in the SLC38A8 gene, which affects the photoreceptor layer of the eye. The researchers included three unrelated female patients with FHONDA syndrome in their study, describing their symptoms and genetic variants. They also observed features of retinitis pigmentosa in one patient, broadening the understanding of the clinical phenotype associated with this rare syndrome. [Extracted from the article]

A recent study conducted in Coimbra, Portugal explored the factors that influence maternal antenatal attachment, which is an important concept in the transition to parenthood. The study involved interviews with 407 pregnant women during their second trimester of pregnancy. The researchers found that factors such as emotional states (depression and anxiety), attitudes towards pregnancy and motherhood, marital satisfaction, and age significantly contribute to maternal antenatal attachment. The study provides valuable insights into understanding and supporting maternal attachment during pregnancy. [Extracted from the article]

A study conducted at the University of Coimbra in Portugal explored the impact of meso-position fluorination on boron dipyrromethane molecules (BODIPYs) and their potential therapeutic applications in breast cancer. The researchers synthesized three BODIPYs with different quantities of fluorine and characterized them using various techniques. The study found that one of the synthesized compounds showed remarkable stability and lacked photocytotoxicity, making it a promising candidate for bioimaging. Additionally, two other BODIPYs were identified as potential candidates for photosensitization in photodynamic therapy for breast cancer. The research suggests that these compounds have notable phototoxic properties and may be effective in this therapeutic approach. [Extracted from the article]

A report from the University of Coimbra in Portugal discusses research on the development of starch aerogels as carriers for iron and folic acid delivery. The study aimed to find novel approaches to enhance nutrient absorption and reduce side effects in the prevention of anemia, particularly in pregnancy. The researchers loaded iron and folic acid into starch gels and found that the release of iron was faster than folic acid in intestinal conditions. The proposed starch aerogel shows promise as a solution and may compete with conventional supplements. The research has been peer-reviewed and published in the Journal of Drug Delivery Science and Technology. [Extracted from the article]

New research conducted by the University of Coimbra in Portugal explores the role of neurovascular dysfunction in psychiatric disorders and potential therapeutic approaches. The study focuses on the blood-brain barrier (BBB) and blood-retinal barrier (BRB), which are crucial for maintaining the central nervous system's homeostasis. The researchers examine the neurovascular alterations associated with anxiety, major depressive disorder, attention-deficit/hyperactivity disorder, and drug abuse. They also investigate the role of neuroinflammation and potential biomarkers in these disorders. The study emphasizes the need for a deeper understanding of BBB and BRB function in neuropsychiatric conditions and their potential as therapeutic targets. [Extracted from the article]

A study conducted by researchers at the University of Coimbra in Portugal evaluated the presence of microbiological hazards, specifically norovirus and Salmonella, in edible macroalgae and halophytes. The study found that the standard method for detecting norovirus in vegetables is suitable for green and red macroalgae, as well as halophytes. However, a process optimization should be considered for brown macroalgae. The study also detected Salmonella in one of the samples analyzed. The researchers concluded that Portuguese coastal areas have great potential for marine agriculture. [Extracted from the article]

A study conducted by researchers at the University of Coimbra in Portugal explores a new multiobjective optimization framework for intensity-modulated radiation therapy (IMRT). The study focuses on the optimization of radiation intensities and beam directions in order to achieve the best tradeoffs between irradiating the tumor and sparing healthy organs. The proposed framework allows for more flexibility in finding solutions and understanding the compromises between different objectives. The research concludes that this approach has the potential to improve the effectiveness of radiation therapy treatment planning. [Extracted from the article]

Researchers from the University of Coimbra in Portugal have conducted a study on congenital skeletal disorders. They found a rare pathological condition in a perinate (birth +/- 2 weeks) from the 17th to 19th centuries, recovered during an excavation at the S & atilde;o Domingos Convent in Lisbon, Portugal. The skeleton exhibited severe shortening and bowing of the long bones, indicating a presumptive diagnosis of skeletal dysplasia. The researchers concluded that the phenotypic features observed were more consistent with thanatophoric dysplasia type 1. This research has been peer-reviewed and published in the International Journal of Osteoarchaeology. [Extracted from the article]