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Objective: The purpose of this study was to evaluate the association of hyperuricemia and metabolic syndrome (MS) in Thai postmenopausal women., Methods: A total of 740 consecutive Thai postmenopausal women were reviewed who were not receiving uric acid or lipid-lowering agents at the Menopause Clinic, Faculty of Medicine Siriraj Hospital, Bangkok, from January 2004 to January 2016. Hyperuricemia was defined as serum uric acid level >5.7 mg/dl. The revised National Cholesterol Education Program (rNCEP) 2004 criteria were used for diagnosis of MS. The association of hyperuricemia and MS was evaluated., Results: Among 740 women, 162 patients (21.9%) were hyperuricemic. The prevalence of MS was 43.8% and 21.8% for hyperuricemic and normo-uricemic women, respectively. Hyperuricemia was significantly associated with increased risk of MS (odds ratio 2.79, 95% confidence interval 1.93-4.0; p < 0.001)., Conclusions: There was a significant association of hyperuricemia and MS in Thai postmenopausal women. These two co-morbidities were common after menopause. When hyperuricemia is diagnosed, MS should be screened, prevented or treated to decrease cardiovascular disease in the future.