In this study we retrospectively examined the results of surgery for atherosclerotic renal artery lesions and analysed the factors that may affect postoperative blood pressure response, changes in renal function and late mortality. A total of 326 patients were operated on over a 15 year period and were followed up for periods from 4 to 165 months (mean follow-up time: 37.2 months). An extra renal vascular area was also involved in 91.4% of cases and in 187 (57.3%) a significant involvement of both renal arteries was found and simultaneously treated. Combined revascularisation of other arteries was performed in 50.3% of patients. The indications for surgery were the treatment of extreme hypertension in 243 patients (74.5%), the improvement of renal function in 45 with renal insufficiency, and preservation of the kidney in 38 (11.7%). The preferred method of reconstruction was transaortic endarterectomy (236 cases, i.e. 72.4%) and postoperative angiography demonstrated a normal patent renal artery in 319 of 338 studied renal arteries (94.4%). There were no deaths in the early postoperative period after isolated renal artery reconstruction. Of the 164 patients with simultaneous renal and aortic reconstruction however 14 died during the early postoperative phase. The overall early mortality was thus 4.3% (14 out of 326 patients) and correlated significantly with the extent of the atherosclerotic disease, the age of the patients, the operative technique used and the different intra- and postoperative management during the two different periods of our experience (1974–1980 v. 1981–1989). At discharge, 115 patients (36.9%) had a normal blood pressure (resting diastolic blood pressure less than 90 mmHg) without any supplemental medication, and in 177 cases (56.7%) the blood pressure returned to normal after reduction of the antihypertensive medication. No improvement in hypertension occurred in 20 (6.4%) patients. Of the 264 patients available for follow-up measurements, 66 (25%) were normotensive without antihypertensive medication and 163 (61.7%) with. Systolic and diastolic blood pressure as well as antihypertensive medication were significantly reduced in both the early postoperative period and at follow-up ( P In the groups with a moderate and severe renal insufficiency (i.e. with plasma creatinine levels of 1.5–2.0 mg% or greater than 2 mg% respectively) the mean plasma creatinine levels decreased significantly during the follow-up period: from 1.7mg% to 1.0 mg% and from 3.9 mg% to 1.2 mg% respectively. The number of patients requiring haemodialysis was reduced from 14 to only four postoperatively. These results show the durable effects of reconstructive surgery in the treatment of severe hypertension and renal insufficiency due to atherosclerotic renal artery occlusive disease.