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A novel atenolol ion-selective electrode is prepared, characterized, and used in pharmaceutical analysis. The electrode incorporates PVC membrane with atenolol-tetrakis(p-chlorophenyl) borate ion-pair complex. The electrode exhibits a Nernstian response for atenolol in the concentration range 3.0 × 10-5 to 8.0 × 10-2 M with a slope of 56.5 ± 0.8mV decade-1. The limit of detection is 1.0 × 10-5 M. The electrode displays a good selectivity for atenolol with respect to a number of common foreign inorganic and organic species. It can be used over a wide pH range of 3.0-9.0. The membrane sensor was successfully applied to the determination of atenolol in its tablets as well as its recovery from blood serum and urine samples. [ABSTRACT FROM AUTHOR]

A novel cimetidine ion-selective electrode is prepared, characterized and used in pharmaceutical analysis. The electrode incorporates PVC-membrane with cimetidine–phospohotungstate ion pair complex. The electrode exhibits a Nernstian response for cimetidine in the concentration range 1.0×10−5–1.0×10−2 M with a slope of 58±1 mV per decade. The limit of detection is 5.0×10−6 M. The electrode displays a good selectivity for cimetidine with respect to a number of common foreign inorganic and organic species. It can be used in the pH range 3.0–5.5. The membrane sensor was successfully applied to the determination of cimetidine in its tablets as well as its recovery from a urine sample. [Copyright &y& Elsevier]

We found that N-[2-[4-[[[(cyclohexyl amino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl pyrazine carboxamide (glipizid) can be used as an excellent ionophore to make a novel samarium-selective membrane sensor. The electrode based on glipizid, containing sodium teraphenyl borate as lipophilic salt and benzyl acetate as a plasticiser, gave the best performance. The electrode exhibits a good Nernstian response towards Sm3+ions in the range of 1.0×10−1 to 1.0×10−6 M with a slope of 19.8 mV per decade. It shows a high selectivity for Sm(III) in comparison with alkali, alkaline earth, heavy metal and transition metal ions. The electrode response and selectivity remained almost unchanged for at least 2 months. The electrode was successfully applied as an indicator electrode in potentiometric titration of Sm(III) ions with EDTA. [Copyright &y& Elsevier]

We have discovered that the antibiotic cefixime (CFI) can be used as a suitable ionophore in PVC membranes having interesting response characteristics for Yb3+ ions. The selective complexation behavior of cefixime with Yb3+ over different metal ions was studied in DMSO solution. The negligible water solubility of cefixime and the increased stability and selectivity of its Yb3+ complex make the antibiotic an attractive ionophore for use in potentiometric poly (vinyl chloride) membrane electrodes for Yb3+. The results revealed a Nernstian response to Yb3+ over concentration range 1.0×10−2–1.0×10−6 M as well as improved selectivity against a wide range of common interferences. The sensor possesses a detection limit of 7.0×10−7 M and can be used in a pH range 3.0–8.0 for at least 8 weeks. [Copyright &y& Elsevier]