1. A new Doppler index, cerebro-placental-uterine ratio, and fetal cardiac parameters in early onset preeclampsia.
- Author
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Oğuz Y, Ağaoğlu RT, Ulusoy CO, Öztürk Ö, Özgürlük İ, Soysal Ç, Yılmaz Vural Z, and Yakut Yücel K
- Subjects
- Humans, Female, Pregnancy, Adult, Fetal Heart diagnostic imaging, Fetal Heart physiopathology, Uterus blood supply, Uterus diagnostic imaging, Pulsatile Flow physiology, Ultrasonography, Prenatal methods, Pre-Eclampsia physiopathology, Pre-Eclampsia diagnostic imaging, Uterine Artery diagnostic imaging, Uterine Artery physiopathology, Ultrasonography, Doppler methods, Umbilical Arteries diagnostic imaging, Umbilical Arteries physiopathology, Middle Cerebral Artery diagnostic imaging, Middle Cerebral Artery physiopathology, Placenta diagnostic imaging, Placenta blood supply
- Abstract
Objective: Our aim was to investigate the significance of cerebro-placento-uterine ratio CPUR, a new Doppler index, and fetal cardiac parameters (Mod MPI, EFT) in early-onset preeclampsia (EOPE) and to examine whether these parameters are related to perinatal outcome., Study Design: Forty participants diagnosed with EOPE (preeclampsia cases diagnosed before 34 weeks of gestation) and 40 healthy pregnant women were included in this study. Demographic data were recorded. Doppler parameters such as middle cerebral artery (MCA), umbilical artery (UA), and uterine artery (Ut-A), and left modified myocardial performance index (Mod-MPI) and epicardial fat thickness (EFT) were measured. Cerebroplacental ratio (CPR) was determined by dividing MCA pulsatility index (PI) by UA PI. CPUR was calculated as the ratio of CPR to mean UtA-PI (CPUR = CPR/UtA-PI). All parameters were compared between the EOPE and control groups. Correlation tests were used to examine the relationship between Doppler parameters and perinatal outcome. p values less than 0.05 were considered statistically significant., Results: The pulsatility index of the middle cerebellar artery, CPUR and CPR values were statistically lower in the EOPE group than in the control group (p = 0.002; p = <0.001; p = <0.001; respectively). No statistical differences were found between groups for isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT), ejection time (ET), left mod-MPI, EFT (p = 0.117; p = 0.093; p = 0.398; p = 0.882; p = 0.202, respectively). Umbilical artery Doppler pulsatility index (PI), mean uterine artery Doppler pulsatility index (PI), were higher in the EOPE group than in the control group (p = 0.006; and p = <0.001, respectively). The CPUR value for predicting EOPE was ≤1.3652 with 74. 4% sensitivity and 94.9% specificity. Positive correlations were found between CPUR, CPR, and some neonatal parameters., Conclusion: CPUR, a new index combining fetal and uterine Doppler indices, may add contribution to predict adverse perinatal outcome and EOPE., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
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