12 results on '"Brophy, Sinead"'
Search Results
2. Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study
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Azcoaga-Lorenzo, Amaya, Fagbamigbe, Adeniyi Francis, Agrawal, Utkarsh, Black, Mairead, Usman, Muhammad, Lee, Siang Ing, Eastwood, Kelly-Ann, Moss, Ngawai, Plachcinski, Rachel, Nelson-Piercy, Catherine, Brophy, Sinead, O’Reilly, Dermot, Nirantharakumar, Krishnarajah, and McCowan, Colin
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- 2023
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3. COVID-19 vaccination in pregnancy: the impact of multimorbidity and smoking status on vaccine hesitancy, a cohort study of 25,111 women in Wales, UK
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Mhereeg, Mohamed, Jones, Hope, Kennedy, Jonathan, Seaborne, Mike, Parker, Michael, Kennedy, Natasha, Akbari, Ashley, Zuccolo, Luisa, Azcoaga-Lorenzo, Amaya, Davies, Alisha, Nirantharakumar, Krishnarajah, and Brophy, Sinead
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- 2023
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4. Key outcomes for reporting in studies of pregnant women with multiple long-term conditions: a qualitative study
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Lee, Siang Ing, Hanley, Stephanie, Vowles, Zoe, Plachcinski, Rachel, Azcoaga-Lorenzo, Amaya, Taylor, Beck, Nelson-Piercy, Catherine, McCowan, Colin, O’Reilly, Dermot, Hope, Holly, Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Singh, Megha, Moss, Ngawai, Brophy, Sinead, Nirantharakumar, Krishnarajah, Thangaratinam, Shakila, and Black, Mairead
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- 2023
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5. Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019
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Subramanian, Anuradhaa, Azcoaga-Lorenzo, Amaya, Anand, Astha, Phillips, Katherine, Lee, Siang Ing, Cockburn, Neil, Fagbamigbe, Adeniyi Francis, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Hope, Holly, Kennedy, Jonathan I., Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Black, Mairead, Loane, Maria, Moss, Ngawai, Plachcinski, Rachel, Thangaratinam, Shakila, Brophy, Sinead, Agrawal, Utkarsh, Vowles, Zoe, Brocklehurst, Peter, Dolk, Helen, Nelson-Piercy, Catherine, and Nirantharakumar, Krishnarajah
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- 2023
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6. Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study
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Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O’Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin
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- 2022
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7. COVID-19 vaccination in pregnancy: views and vaccination uptake rates in pregnancy, a mixed methods analysis from SAIL and the Born-In-Wales Birth Cohort
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Mhereeg, Mohamed, Jones, Hope, Kennedy, Jonathan, Seaborne, Mike, Parker, Michael, Kennedy, Natasha, Beeson, Sarah, Akbari, Ashley, Zuccolo, Luisa, Davies, Alisha, and Brophy, Sinead
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- 2022
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8. Echogenic intracardiac foci detection and location in the second-trimester ultrasound and association with fetal outcomes: A systematic literature review.
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Jones, Hope Eleri, Battaglia, Serica, Hurt, Lisa, Uzun, Orhan, and Brophy, Sinead
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FETAL movement ,FETAL ultrasonic imaging ,VENTRICULAR septal defects ,TRICUSPID valve insufficiency ,PREMATURE labor ,PREGNANCY ,MITRAL valve insufficiency - Abstract
Background: Echogenic Intracardiac Foci (EIF) are non-structural markers identified during the routine 18–20-week foetal anomaly ultrasound scan yet their clinical significance on future outcomes for the infant is unclear. Objective: To examine the association between EIF and risk of preterm birth, chromosomal abnormalities, and cardiac abnormalities. Design: A review across four databases to identify English language journal articles of EIF using a cohort study design. All studies were reviewed for quality using the Critical Appraisal Skills Programme (CASP) checklist and data extracted for comparison and analysis. Results: 19 papers from 9 different countries were included. Combining these studies showed 4.6% (95% CI = 4.55–4.65%) of all pregnancies had EIF which was on the left in 86% of cases, on the right in 3% of cases and bilaterally in 10%. There was no evidence that EIF was associated with higher rates of preterm birth. However, it is possible that infants with EIF were more likely to be terminated rather than be born preterm as there was a 2.1% (range 0.3–4.2%) rate of termination or death of the foetus after week 20 among those with EIF. There was no evidence that EIF alone is highly predictive of chromosomal abnormalities. There was evidence that EIF is associated with higher rates of minor cardiac abnormalities (e.g. ventricular septal defect, tricuspid regurgitation or mitral regurgitation)) with 5.1% (224 of 4385) of those with EIF showing cardiac abnormalities (3.08% in retrospective studies and 17.85% in prospective studies). However, the risk of cardiac defects was only higher with right-sided EIF and where the EIF persisted into the third trimester. However, this is a rare event and would be seen in an estimated 4 per 10,000 pregnancies. Conclusion: EIF alone was not associated with adverse outcomes for the infant. Only persistent EIF on the right side showed evidence of carrying a higher risk of cardiac abnormality and would warrant further follow-up. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Maternal and child outcomes for pregnant women with pre-existing multiple long-term conditions: protocol for an observational study in the UK
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Lee, Sian Ing, Hope, Holly, O'Reilly, Dermot, Kent, Lisa, Santorelli, Gillian, Subramanian, Anuradhaa, Moss, Ngawai, Azcoaga-Lorenzo, Amaya, Fagbamigbe, Adeniyi, Nelson-Piercy, Catherine, Yau, Christopher, McCowan, Colin, Kennedy, Jonathan I, Phillips, Katherine, Singh, Megha, Mhereeg, Mohamed, Cockburn, Neil, Brocklehurst, Peter, Plachcinski, Rachel, Riley, Richard, Thangaratinam, Shakila, Brophy, Sinead, Sudasinghe, Sudasing Pathirannehelage Buddhika Hemali, Agrawal, Utkarsh, Vowles, Zoe, Abel, Kathryn M, Nirantharakumar, Krishnarajah, Black, Mairead, Eastwood, Kelly-Ann, MuM-PreDiCT Group, University of St Andrews. School of Medicine, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, and University of St Andrews. Population and Behavioural Science Division
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Adult ,Adolescent ,Maternity ,OBSTETRICS ,Maternal medicine ,Young Adult ,Offspring ,SDG 3 - Good Health and Well-being ,Pregnancy ,RA0421 ,RA0421 Public health. Hygiene. Preventive Medicine ,Humans ,EPIDEMIOLOGY ,Child ,Children ,Outcome ,Multiple long-term conditions ,MCC ,Wales ,Mental Disorders ,Multimorbidity ,Obstetric ,3rd-DAS ,General Medicine ,Middle Aged ,Observational Studies as Topic ,Scotland ,England ,Multiple chronic conditions ,RG Gynecology and obstetrics ,Female ,Pregnant Women ,RG - Abstract
Funding: This work is funded by the Strategic Priority Fund 'Tackling multimorbidity at scale' programme (grant number MR/W014432/1) delivered by the Medical Research Council and the National Institute for Health Research (NIHR) in partnership with the Economic and Social Research Council and in collaboration with the Engineering and Physical Sciences Research Council. Introduction One in five pregnant women has multiple pre-existing long-term conditions in the UK. Studies have shown that maternal multiple long-term conditions are associated with adverse outcomes. This observational study aims to compare maternal and child outcomes for pregnant women with multiple long-term conditions to those without multiple long-term conditions (0 or 1 long-term conditions). Methods and analysis Pregnant women aged 15–49 years old with a conception date between 2000 and 2019 in the UK will be included with follow-up till 2019. The data source will be routine health records from all four UK nations (Clinical Practice Research Datalink (England), Secure Anonymised Information Linkage (Wales), Scotland routine health records and Northern Ireland Maternity System) and the Born in Bradford birth cohort. The exposure of two or more pre-existing, long-term physical or mental health conditions will be defined from a list of health conditions predetermined by women and clinicians. The association of maternal multiple long-term conditions with (a) antenatal, (b) peripartum, (c) postnatal and long-term and (d) mental health outcomes, for both women and their children will be examined. Outcomes of interest will be guided by a core outcome set. Comparisons will be made between pregnant women with and without multiple long-term conditions using modified Poisson and Cox regression. Generalised estimating equation will account for the clustering effect of women who had more than one pregnancy episode. Where appropriate, multiple imputation with chained equation will be used for missing data. Federated analysis will be conducted for each dataset and results will be pooled using random-effects meta-analyses. Ethics and dissemination Approval has been obtained from the respective data sources in each UK nation. Study findings will be submitted for publications in peer-reviewed journals and presented at key conferences. Publisher PDF
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- 2023
10. Mild-to-moderate renal pelvis dilatation identified during pregnancy and hospital admissions in childhood: An electronic birth cohort study in Wales, UK
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Hurt, Lisa, Wright, Melissa, Demmler, Joanne, VanDerVoort, Judith, Morris, Susan, Brook, Fiona, Tucker, David, Chapman, Maria, Francis, Nick A., Daniel, Rhian, Fone, David, Brophy, Sinead, and Paranjothy, Shantini
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Neonatal screening -- Methods -- Patient outcomes ,Prenatal diagnosis -- Patient outcomes ,Chronic kidney failure -- Risk factors -- Demographic aspects ,Hospital admission and discharge ,Surgery ,Kidney diseases ,Urinary tract infections ,Pregnancy ,Medical research ,Pregnant women ,Children ,Biological sciences - Abstract
Background Chronic kidney disease (CKD) is a growing contributor to the global burden of noncommunicable diseases. Early diagnosis and treatment can reduce the severity of kidney damage and the need for dialysis or transplantation. It is not known whether mild-to-moderate renal pelvis dilatation (RPD) identified at 18-20 weeks gestation is an early indicator of renal pathology. The aim of this follow-up to the Welsh Study of Mothers and Babies was to assess the risk of hospital admission in children with mild-to-moderate antenatal RPD compared with children without this finding. We also examined how the natural history of the RPD (whether the dilatation persists in later pregnancy or postpartum) or its characteristics (unilateral versus bilateral) changed the risk of hospital admission. Methods/Findings This population-based cohort study included singleton babies born in Wales between January 1, 2009, and December 31, 2011 (n = 22,045). We linked ultrasound scan data to routinely available data on hospital admissions from the Patient Episode Database for Wales (PEDW). The outcome was a hospital admission for urinary tract causes (defined by an expert study steering group) in the first three years of life. We used Cox regression to model time to first hospital admission, according to whether there was evidence of RPD at the fetal anomaly scan (FAS) and/or evidence of dilatation in later investigations, adjusting for other predictors of admission. We used multiple imputation with chained equations to impute values for missing data. We included 21,239 children in the analysis. The risk of at least one hospital admission was seven times greater in those with RPD (n = 138) compared with those without (n = 21,101, conditional hazard ratio [cHR] 7.23, 95% confidence interval [CI] 4.31-12.15, p < 0.001). The risk of hospital admission was higher in children with RPD at the FAS and later dilatation (cHR 25.13, 95% CI 13.26-47.64, p < 0.001) and in children without RPD at the FAS who had later dilatation (cHR 62.06, 95% CI 41.10-93.71, p < 0.001) than in children without RPD (n = 21,057). Among children with RPD at the FAS but no dilatation in later pregnancy or postpartum, we did not find an association with hospital admissions (cHR 2.16, 95% CI 0.69-6.75, p = 0.185), except when the initial dilatation was bilateral (cHR 4.77, 95% CI 1.17-19.47, p = 0.029). Limitations of the study include small numbers in subgroups (meaning that these results should be interpreted with caution), that less severe outcomes (such as urinary tract infections [UTIs] managed in the community or in outpatients) could not be included in our analysis, and that obtaining records of radiological investigations later in pregnancy and postpartum was challenging. Our conclusions were consistent after conducting sensitivity analyses to account for some of these limitations. Conclusions In this large population-based study, children with RPD at the FAS had higher rates of hospital admissions when there was persistent dilatation in later pregnancy or postpartum. Our results can be used to improve counselling of parents and develop care pathways for antenatal screening programmes, including protocols for reporting and further investigation of RPD., Author(s): Lisa Hurt 1, Melissa Wright 2, Joanne Demmler 3, Judith VanDerVoort 4, Susan Morris 4, Fiona Brook 5, David Tucker 6, Maria Chapman 7, Nick A. Francis 1, Rhian [...]
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- 2019
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11. Age within schoolyear and attention-deficit hyperactivity disorder in Scotland and Wales
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Fleming, Michael, Bandyopadhyay, Amrita, McLay, James S., Clark, David, King, Albert, Mackay, Daniel F., Lyons, Ronan A., Sayal, Kapil, Brophy, Sinead, and Pell, Jill P.
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Schools ,Wales ,Attention Deficit Disorder with Hyperactivity ,Pregnancy ,Public Health, Environmental and Occupational Health ,Prevalence ,Educational Status ,Humans ,Female ,Child - Abstract
Background Previous studies suggest an association between age within schoolyear and attention-deficit hyperactivity disorder (ADHD). Scotland and Wales have different school entry cut-off dates (six months apart) and policies on holding back children. We aim to investigate the association between relative age and treated attention deficit hyperactivity disorder (ADHD) in two countries, accounting for held-back children. Methods Routine education and health records of 1,063,256 primary and secondary schoolchildren in Scotland (2009–2013) and Wales (2009–2016) were linked. Logistic regression was used to examine the relationships between age within schoolyear and treated ADHD, adjusting for child, maternity and obstetric confounders. Results Amongst children in their expected school year, 8,721 (0.87%) had treated ADHD (Scotland 0.84%; Wales 0.96%). In Wales, ADHD increased with decreasing age (youngest quartile, adjusted OR 1.32, 95% CI 1.19–1.46) but, in Scotland, it did not differ between the youngest and oldest quartiles. Including held-back children in analysis of their expected year, the overall prevalence of treated ADHD was 0.93%, and increased across age quartiles in both countries. More children were held back in Scotland (57,979; 7.66%) than Wales (2,401; 0.78%). Held-back children were more likely to have treated ADHD (Scotland OR 2.18, 95% CI 2.01–2.36; Wales OR 1.70, 95% CI 1.21–2.31) and 81.18% of held-back children would have been in the youngest quartile of their expected year. Conclusions Children younger within schoolyear are more likely to be treated for ADHD, suggesting immaturity may influence diagnosis. However, these children are more likely to be held back in countries that permit flexibility, attenuating the relative age effect.
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- 2021
12. Physical Activity and Excess Weight in Pregnancy Have Independent and Unique Effects on Delivery and Perinatal Outcomes.
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Morgan, Kelly L., Rahman, Muhammad A., Hill, Rebecca A., Zhou, Shang-Ming, Bijlsma, Gunnar, Khanom, Ashrafunnesa, Lyons, Ronan A., and Brophy, Sinead T.
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CHILDREN'S health ,PREGNANCY complications ,HEALTH outcome assessment ,BODY mass index ,MATERNAL health services ,GESTATIONAL age - Abstract
Background: This study examines the effect of low daily physical activity levels and overweight/obesity in pregnancy on delivery and perinatal outcomes. Methods: A prospective cohort study combining manually collected postnatal notes with anonymised data linkage. A total of 466 women sampled from the Growing Up in Wales: Environments for Healthy Living study. Women completed a questionnaire and were included in the study if they had an available Body mass index (BMI) (collected at 12 weeks gestation from antenatal records) and/or a physical activity score during pregnancy (7-day Actigraph reading). The full statistical model included the following potential confounding factors: maternal age, parity and smoking status. Main outcome measures included induction rates, duration of labour, mode of delivery, infant health and duration of hospital stay. Findings: Mothers with lower physical activity levels were more likely to have an instrumental delivery (including forceps, ventouse and elective and emergency caesarean) in comparison to mothers with higher activity levels (adjusted OR:1.72(95%CI: 1.05 to 2.9)). Overweight/obese mothers were more likely to require an induction (adjusted OR:1.93 (95%CI 1.14 to 3.26), have a macrosomic baby (adjusted OR:1.96 (95%CI 1.08 to 3.56) and a longer hospital stay after delivery (adjusted OR:2.69 (95%CI 1.11 to 6.47). Conclusions: The type of delivery was associated with maternal physical activity level and not BMI. Perinatal outcomes (large for gestational age only) were determined by maternal BMI. [ABSTRACT FROM AUTHOR]
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- 2014
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