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Your search keyword '"Groth KA"' showing total 2 results
Start Over Author "Groth KA" Topic pregnancy complications, cardiovascular
2 results on '"Groth KA"'

1. Maternal health and pregnancy outcome in diagnosed and undiagnosed Marfan syndrome: A registry-based study.

Author

Groth KA, Nielsen BB, Sheyanth IN, Gravholt CH, Andersen NH, and Stochholm K

Subjects
Adult, Aortic Diseases epidemiology, Aortic Diseases physiopathology, Female, Fetal Death, Humans, Marfan Syndrome epidemiology, Pregnancy, Pregnancy Complications, Cardiovascular epidemiology, Pregnancy Outcome, Registries, Marfan Syndrome physiopathology, Maternal Health, Pregnancy Complications, Cardiovascular physiopathology
Abstract

In Marfan syndrome (MFS), pregnancy is considered as high risk due to the deficiency of fibrillin in the connective tissue and increased risk of aortic dissection. The objective was to demonstrate the consequences on maternal health, in women with diagnosed and undiagnosed MFS at the time of pregnancy and childbirth. By using national health care registries, we identified all pregnancy related outcomes, from women with MFS (n = 183) and an age-matched background population (n = 18,300). We found 91 pregnancies during follow-up. Significantly fewer women with MFS gave birth, compared to the background population. No women with known MFS had a pregnancy related aortic dissection but complications related to the cervix were increased (HR:19.8 [95% CI:2.2-177.5]). Fifty women with MFS were undiagnosed at the time of their first pregnancy and/or childbirth. Among these, there were more birth canal related complications HR:27.2 (95% CI: 2.3-315.0), preeclampsia (HR:2.25 [95% CI: 1.11-4.60]), fetal deaths (HR:12.3 [95% CI: 1.51-99.8]), and all delivery-related dissections came from this subgroup. In conclusion, undiagnosed women with MFS experienced more pregnancy and childbirth related complications including fetal death, birth canal issues, preeclampsia, and aortic disease, which emphasizes the need for an early MFS diagnosis and special care during pregnancy and childbirth., (© 2021 Wiley Periodicals LLC.)

Published
2021
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2. [High-risk pregnancy in a woman with Marfan syndrome, a bicuspid aortic valve, and a dilated aortic sinus].

Author

Groth KA, Greisen JR, Nielsen BB, and Andersen NH

Subjects
Adult, Antihypertensive Agents therapeutic use, Aortic Valve diagnostic imaging, Bicuspid Aortic Valve Disease, Cesarean Section, Dilatation, Pathologic prevention & control, Echocardiography, Female, Heart Valve Diseases diagnostic imaging, Humans, Marfan Syndrome diagnostic imaging, Pregnancy, Pregnancy Complications, Cardiovascular diagnostic imaging, Sinus of Valsalva diagnostic imaging, Aortic Valve abnormalities, Heart Valve Diseases complications, Marfan Syndrome complications, Pregnancy Complications, Cardiovascular prevention & control, Pregnancy, High-Risk
Abstract

A 29-year-old woman with Marfan syndrome, a bicuspid aortic valve, and a dilated aortic sinus (5.2 cm) presented herself in clinic 14 weeks pregnant. She was advised to discontinue the pregnancy due to risk of dissection; however, she decided to continue. She was treated with labetalol (300 mg/day) to reduce blood pressure and was admitted for bed rest from week 30. Her aortic diameter was assessed by echocardiography every 2nd week and remained unchanged. She was treated with betamethason at week 26 and the child was born by a caesarean section in week 35. The post-operative course was uneventful.

Published
2015

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