1. Pregnancy outcomes in patients with vitiligo: A nationwide population-based cohort study from Korea.
- Author
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Park KY, Kwon HJ, Wie JH, Lee HH, Cho SB, Kim BJ, and Bae JM
- Subjects
- Adolescent, Adult, Case-Control Studies, Female, Fetal Growth Retardation etiology, Gestational Age, Humans, Incidence, Infant, Newborn, Logistic Models, Multivariate Analysis, Pregnancy, Pregnancy Complications epidemiology, Premature Birth, Republic of Korea, Retrospective Studies, Risk Assessment, Stillbirth, Vitiligo diagnosis, Young Adult, Abortion, Spontaneous epidemiology, Fetal Growth Retardation epidemiology, Pregnancy Complications diagnosis, Pregnancy Outcome, Vitiligo complications
- Abstract
Background: Vitiligo is a chronic autoimmune skin disorder affecting 1% of populations worldwide. Few large-scale studies have explored adverse pregnancy outcomes in patients with vitiligo., Objective: To investigate adverse pregnancy outcomes in patients with vitiligo., Methods: We performed a retrospective cohort study on 4738 pregnancies of women with vitiligo and 47,380 pregnancies of age-matched controls without vitiligo using the Korean National Health Insurance Claims database from 2007 to 2016. Multivariate logistic regression models were used to evaluate the associations between vitiligo and pregnancy outcomes, including live births, spontaneous abortion, cesarean delivery, preterm delivery, gestational diabetes mellitus, stillbirth, pre-eclampsia/eclampsia, and intrauterine growth retardation., Results: Patients with vitiligo exhibited a significantly lower live birth rate (odds ratio, 0.870; 95% confidence interval, 0.816-0.927) and a higher incidence of spontaneous abortion (odds ratio, 1.250; 95% confidence interval, 1.148-1.362) than the control group., Limitation: The Korean National Health Insurance Claims database lacks detailed clinical information on individual patients., Conclusion: Vitiligo was significantly associated with an increased risk of spontaneous abortion. Further studies are needed to determine whether systemic autoimmunity explains our finding., (Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
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