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Your search keyword '"Modzelewska D"' showing total 3 results
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3 results on '"Modzelewska D"'

1. Genetic effects on the timing of parturition and links to fetal birth weight.

Author

Solé-Navais P, Flatley C, Steinthorsdottir V, Vaudel M, Juodakis J, Chen J, Laisk T, LaBella AL, Westergaard D, Bacelis J, Brumpton B, Skotte L, Borges MC, Helgeland Ø, Mahajan A, Wielscher M, Lin F, Briggs C, Wang CA, Moen GH, Beaumont RN, Bradfield JP, Abraham A, Thorleifsson G, Gabrielsen ME, Ostrowski SR, Modzelewska D, Nohr EA, Hypponen E, Srivastava A, Talbot O, Allard C, Williams SM, Menon R, Shields BM, Sveinbjornsson G, Xu H, Melbye M, Lowe W Jr, Bouchard L, Oken E, Pedersen OB, Gudbjartsson DF, Erikstrup C, Sørensen E, Lie RT, Teramo K, Hallman M, Juliusdottir T, Hakonarson H, Ullum H, Hattersley AT, Sletner L, Merialdi M, Rifas-Shiman SL, Steingrimsdottir T, Scholtens D, Power C, West J, Nyegaard M, Capra JA, Skogholt AH, Magnus P, Andreassen OA, Thorsteinsdottir U, Grant SFA, Qvigstad E, Pennell CE, Hivert MF, Hayes GM, Jarvelin MR, McCarthy MI, Lawlor DA, Nielsen HS, Mägi R, Rokas A, Hveem K, Stefansson K, Feenstra B, Njolstad P, Muglia LJ, Freathy RM, Johansson S, Zhang G, and Jacobsson B

Subjects
Pregnancy, Infant, Newborn, Female, Humans, Birth Weight genetics, Gestational Age, Parturition genetics, Premature Birth genetics
Abstract

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n = 136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal-fetal relationship between gestational duration and birth weight., (© 2023. The Author(s).)

Published
2023
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2. [Preterm delivery: an overview on epidemiology, pathophysiology and consequences for the individual and the society].

Author

Jacobsson B, Pettersson K, Modzelewska D, Abrahamsson T, Bergman L, and Håkansson S

Subjects
Chorioamnionitis, Developmental Disabilities epidemiology, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases epidemiology, Pregnancy, Pregnancy Outcome, Risk Factors, Sweden epidemiology, Premature Birth economics, Premature Birth epidemiology, Premature Birth etiology
Abstract

Preterm delivery in Sweden constitutes 5.7 % of all deliveries, which is among the lowest rates in the world. There has not been any increase in the proportion of iatrogenic preterm deliveries during the last decades.The main hypothesis concerning the causality of preterm delivery is still that of the ascending infection from the vagina to the uterus and inflammation resulting in contractions, rupture of membranes and delivery. The mechanisms behind parturition at term are still elusive and this is also true for preterm delivery. The genetic contribution to preterm delivery is about 25-30 %. The first genes that are associated with preterm delivery and gestational duration have recently been published. Huge progress has been made in care of preterm born infants. Sweden has among the lowest rates of mortality and morbidity in the world, especially in the lowest gestational weeks. New modes of care, family-centered care and hospital-assisted home care, have empowered the parents and reduced the cost for care.

Published
2019

3. Caffeine exposure during pregnancy, small for gestational age birth and neonatal outcome – results from the Norwegian Mother and Child Cohort Study

Author

Verena Sengpiel, Bo Jacobsson, Anders Elfvin, Helle Margrete Meltzer, Rino Bellocco, Anne Lise Brantsæter, Dominika Modzelewska, Modzelewska, D, Bellocco, R, Elfvin, A, Lise Brantsæter, A, Margrete Meltzer, H, Jacobsson, B, and Sengpiel, V

Subjects
Adult, medicine.medical_specialty, Reproductive medicine, Gestational Age, Norwegian, Logistic regression, Coffee, lcsh:Gynecology and obstetrics, Infant, Newborn, Diseases, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pregnancy, Caffeine, medicine, Birth Weight, Humans, 030212 general & internal medicine, Registries, lcsh:RG1-991, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, Norway, Infant, Newborn, Obstetrics and Gynecology, Small for gestational age, Infant, Low Birth Weight, Neonatal outcome, medicine.disease, language.human_language, 3. Good health, Low birth weight, Logistic Models, Maternal Exposure, Infant, Small for Gestational Age, language, Gestation, Premature Birth, Female, Norwegian mother and child cohort study, medicine.symptom, business, Cohort study, Research Article
Abstract

Background Maternal caffeine intake has repeatedly been linked to babies being born small for gestational age (SGA). SGA babies are known to be at increased risk for adverse neonatal outcomes. The aim of this study was to explore the associations between prenatal caffeine exposure and neonatal health. Methods The study is based on 67,569 full-term singleton mother-infant pairs from the Norwegian Mother and Child Cohort Study. Caffeine consumption from different sources was self-reported in gestational week 22. Neonatal compound outcomes, namely (1) morbidity/mortality and (2) neonatal intervention, were created based on the Medical Birth Registry of Norway. Adjusted logistic regression was performed. Results Caffeine exposure was associated to SGA (OR = 1.16, 95%CI: 1.10; 1.23) and being born SGA was significantly associated with neonatal health (OR = 3.09, 95%CI: 2.54; 3.78 for morbidity/mortality; OR = 3.94, 95%CI: 3.50; 4.45 for intervention). However, prenatal caffeine exposure was neither associated with neonatal morbidity/mortality (OR = 1.01, 95%CI: 0.96; 1.07) nor neonatal intervention (OR = 1.02, 95%CI: 1.00; 1.05 for a 100 mg caffeine intake increase). Results did not change after additional adjustment for SGA status. Conclusions Moderate prenatal caffeine exposure (

Published
2019
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