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Reach-scale experiments simulating the physical characteristics of natural woody plants are required for the improved modeling of flow resistance in channels with instream and floodplain vegetation. The first aim of this study was to investigate the flow resistance caused by patches of foliated woody vegetation at low volumetric blockage factors (4% to 10%) under emergent conditions, as most studies on the effect of patchiness are limited to submerged aquatic plants. Experiments with nature-like willow patches were performed in a reach-scale outdoor flume, where the density and layout of the patches were altered. The bulk friction factors were based on the friction slopes, calculated using the water surface slopes and velocity heads measured by a set of high-accuracy pressure sensors under several flow conditions. Compared to unvegetated conditions, the patches increased the bulk friction factor by 1.7–5.5 times, depending on the patch density and blockage factor. The second aim of this study was to evaluate the performance of four momentum-based models in estimating the bulk friction factors in flows with such flexible patches. For this process, a methodological approach suited for patchy woody vegetation at reach scale was developed to determine the input parameters required in each model. Estimation results using the newly modified and parameterized formulas compared favorably to the experimental data, demonstrating more reliable performance for models explicitly addressing the reconfiguration of vegetation. Overall, this study provides a practical methodology for estimating flow resistance caused by complex distributions of woody riverine vegetation. [ABSTRACT FROM AUTHOR]