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Start Over Author "Kong, Xiaojie" Topic prodrugs
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1. NAD(P)H: quinone oxidoreductase 1 activatable toll-like receptor 7/8 agonist designed for precise immunotherapy.

Author

Li G, Xu Y, Kong X, Gu L, Qin Y, and Wu L

Subjects
Humans, NAD, Toll-Like Receptor 7, NAD(P)H Dehydrogenase (Quinone), Quinones pharmacology, Tumor Microenvironment, Neoplasms drug therapy, Prodrugs pharmacology
Abstract

An NQO1-responsive precursor, named R848-QPA, has been developed to evoke an anti-tumor immune response. R848-QPA can induce innate immune activation when activated by overexpressed NQO1 in the tumor microenvironment while showing lower activity in NQO1-deprived environments. This strategy provides a new method for the development of tumor-microenvironment-responsive prodrugs for antitumor immunotherapy.

Published
2023
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