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Objective · To investigate the clinicopathological features, diagnosis and prognosis of rectal neuroendocrine neoplasms (R-NENs). Methods · The clinical data of 113 cases of R-NENs, January 2008 to June 2017, were collected in Renji Hospital, Shanghai Jiao Tong University School of Medicine, and the clinicopathological features and prognostic factors were retrospectively analyzed. The of synapsin (Syn), neural cell adhesion molecule (CD56), and chromogranin A (CgA) were observedimmunohistochemistry in the R-NENs specimens. The specimens were also observed after hematoxylin-eosin staining. Results · In 113 cases of R-NENs, there were 59 males and 54 females, and their ages ranged 25 to 83 with an average age of (52.3±13.3) years old. All the patients had no obvious clinical manifestations. The main symptoms included changes in bowel habits (21.3%), abdominal pain (8.9%) and anal symptoms (6.2 %), and 63.7% of cases were found in routine medical examinations. The R-NENs were diagnosed as G1 (79.6%), G2 (11.5%), and G3 (8.8%). Immunohistochemistry results demonstrated that 94.7% of tumors were positive for Syn, 80.9% for CD56, and 48.6% for CgA. Till November 2017, the median survival time was 33.10 months (0.40–114.67 months), with 1-year, 3-year, and 5-year survival rates of 93.8%, 90.0%, and 85.9%, respectively. The pathological grade, depth of tumor invasion, lymph node metastasis or distant metastasis, tumor size, and age were all associated with prognosis of patients with R-NENs. Conclusion · Most of R-NENs are low-grade malignant tumors with good overall prognosis and have a lack of specificity in clinical manifestations. [ABSTRACT FROM AUTHOR]

Objective · To investigate the clinicopathologic characteristics and prognosis of adult rhabdomyosarcoma (RMS). Methods · The clinical and pathological data, immunohistochemical test results of 9 RMS were analyzed retrospectively. Results · The information of 6 males and 3 females were collected in this research, whose average age was (46.89±20.09) years old. The tumors had a wide range distribution. The subtypes of histology included 6 cases of embryonal RMS, 1 case of alveolar RMS, 1 case of spindle cell RMS and 1 case of pleomorphic RMS. Immunohistochemically study showed that 6 cases were myogenin positive, 4 cases were MyoD1 positive and 8 cases were desmin positive. During the follow-up period of the 7 cases, only 2 patients survived free of tumors, 2 patients presented with tumor recurrence and metastasis after the operations, and 3 patients died of tumor. Conclusion · In this study, embryonal RMS is the most common type, and immunohistochemistry test is helpful to diagnosis of RMS. [ABSTRACT FROM AUTHOR]

Objective To investigate the CT features and clinical significance of pseudo-subarachnoid hemorrhage sign (PSAH) with diffuse brain edema. Methods CT of 13 patients including 5 brain-dead organ donors with non-hemorrhagic disease and 8 non-traumatic critically ill patients with confirmed P-SAH from March 2019 to December 2019 was reviewed. Regions of interest (ROI) were drawn on the cerebral white matter (100 mm²) and fissure (10 mm²) symmetrically on plain CT. The CT values were measured and compared between the 2 groups. The clinical prognosis of non-traumatic critically ill patients was observed. Results On all patients, CT showed diffuse swelling of brain parenchyma, low density, blurred gray-white matter boundary, narrow ventricle under pressure, symmetrically high and linear attenuation in basal cistern and sulci. The CT values in brain death were (26.25±2.28) HU (range: 21.90- 29.8 HU) in the white matter and (41.45±2.42) HU (range: 35.1-45.0 HU) in the fissures. The CT values in non-traumatic critically ill patients were (26.02±2.20) HU (range: 21.9-29.8 HU) in the white matter and (45.07±4.47) HU (range: 35.1-56.9 HU) in the fissures. The average CT value difference of white matter and fissures in all cases were (17.54±3.05) HU. Conclusion In severe diffuse brain edema, typical P-SAH can be seen on plain CT, and the presence of P-SAH often indicates a poor prognosis. [ABSTRACT FROM AUTHOR]

Primary liver adenosquamous carcinoma is a rare kind of liver malignant tumor with very poor prognosis. Clinical data of 5 cases were analyzed retrospectively, four male and one female, whose average age was 60.2 years (50-67 years) old. Adenosquamous carcinoma contains both adenocarcinoma and squamous carcinoma histologically, and squamous carcinoma cells are dominant (>80%). Four cases underwent surgical resection and one received liver transplantation. The postoperative follow-up period ranged from 6 to 35 months and the mean survival time of these cases was about 15 months. Three patients died during the follow-up period. The survival rates 1 and 2 years after operation were 60% and 20%, respectively. [ABSTRACT FROM AUTHOR]