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Copyright of Cancer Research on Prevention & Treatment is the property of Cancer Research on Prevention & Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...

Copyright of Cancer Research on Prevention & Treatment is the property of Cancer Research on Prevention & Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...

Objective: To analyze the common pathogenic bacteria and drug resistance of patients with abdominal infection after colorectal cancer surgery, and to explore the risk factors and the effect on the prognosis of patients. Methods: A retrospective study was conducted on 225 patients who underwent radical operation for colorectal cancer from January 2012 to January 2015. According to the occurrence of abdominal infection after operation, the patients were divided into infection group (31 cases) and uninfected group (194 cases). The suspected infected patients were identified by pathogen culture and drug sensitivity test, and the risk factors of abdominal infection after radical operation for colorectal cancer were analyzed. The mortality, progression-free survival (PFS) and recurrence rates were compared between the two groups. Results: The incidence of abdominal infection with patients after colorectal cancer surgery was 13.77%. A total of 67 strains of strains detected, gram negative bacteria had the highest detection rate, followed by gram-positive bacteria and fungi. Escherichia coli was sensitive to imipenem and the drug resistance rate was 0% . Klebsiella pneumoniae was sensitive to imipenem, Amikacin and tobramycin, and the drug resistance rates were 0%. Pseudomonas aeruginosa was sensitive to tobramycin, and the drug resistance rate was 11.11% . Staphylococcus epidermidis was more sensitive to levofloxacin, tobramycin, ciprofloxacin and imipenem, and the drug resistance rates were 0%, 0%, 12.50% and 12.50% respectively. Single factor analysis showed that abdominal infection after colorectal cancer surgery was related to preoperative hemoglobin level, preoperative serum albumin level, diabetes mellitus, TNM stage, Dukes stage, operation type, operation time, intraoperative bleeding, viscera resection, postoperative stoma, anastomotic fistula and postoperative drainage tube retention time (P<0.05). Multiple Logistic regression analysis showed that combined diabetes mellitus, combined visceral resection, preoperative serum albumin level<35 g/L, operation time>160 min, postoperative stoma, anastomotic fistula and postoperative drainage tube retention time≥ 11d were the independent risk factors of abdominal infection after colorectal cancer surgery (P<0.05). Compared with the uninfected group, the 3-year mortality and recurrence rate of the infected group was higher, and PFS was significantly shortened (P<0.05). Conclusion: Abdominal infection after colorectal cancer surgery is affected by many factors, with high infection rate and poor prognosis. The infection pathogenic bacteria are mainly gram-negative bacteria, and the antibiotics have certain resistance. Preventive measures should be taken for patients with diabetes mellitus, low preoperative serum albumin level,intraoperative combined visceral resection, long operation time, postoperative stoma, anastomotic fistula and long postoperative drainage tube retention time to prevent post-operative infection, and imipenem and tobramycin can be used to prevent and treat peritoneal infection caused by drug-resistant bacteria after radical resection of colorectal cancer. [ABSTRACT FROM AUTHOR] more...

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...

Objective To analyze the prognostic risk factors for hepatic encephalopathy (HE), and to explore the risk factors for prognosis. MethodsA total of 385 patients with HE who were treated in Liaocheng People′s Hospital from January 2006 to June 2014 were enrolled in this study and analyzed retrospectively. These patients were divided into improved group (n=125) and deteriorated group (n=260). A total of 25 clinical indices were selected, and non-conditional binary logistic regression analysis was performed for related data with SPSS. ResultsUnivariate analysis showed that HE stage, upper gastrointestinal hemorrhage, hepatorenal syndrome (HRS), total bilirubin (TBil), and international normalized ratio (INR) were risk factors affecting the prognosis of HE (P=0.000, 0.009, 0.047, 0.002, and 0.027, respectively). Multivariate logistic regression analysis was further performed for the variables with statistical significance and the results showed that HE stage, upper gastrointestinal hemorrhage, HRS, TBil, and INR were independent risk factors affecting the prognosis of HE (P=0.000, 0.009, 0.000, 0.000, and 0.008, respectively; OR(95%CI)=4.388 (2.997-6.424), 2.805 (1.300-6.050), 4.036 (2.018-8.072), 1.005 (1.003-1.007), and 1.446 (1.099-1.901), respectively). Conclusion HE stage, upper gastrointestinal hemorrhage, HRS, TBil, and INR are risk factors affecting the prognosis of HE, and advanced HE stages, a high level of bilirubin, high INR, and presence of upper gastrointestinal hemorrhage and HRS indicate poor prognosis. The patient′s HE stage, upper gastrointestinal hemorrhage, HRS, TBil, and INR are applied as the indices for prognosis of HE, and the equation based on the these indices may have a reference value in clinical practice. [ABSTRACT FROM AUTHOR] more...

Objective: To investigate the expression and clinical significance of DcR3 (Decoy receptor 3) protein in human oesophageal squamous cell carcinoma. Methods: Expression status of DcR3 was detected by immunohistochemistry in 112 cases of normal esophageal tissues and oesophageal squamous cell carcinoma tissues. Expressions, correlations and clinical significance of DcR3 protein were also analyzed. Results: In oesophageal squamous cell carcinoma tissues,the positive expression of DcR3 protein was 72.3％ and in normal esophageal tissues the postive expression of DcR3 protein was 25.9％. The chi square test suggested that DcR3 protein expression was correlated with clinical stage (P=0.002), lymph node metastasis (P＜0.001), histological differentiation (P=0.01), but was not correlated with age (P=0.673), gender (P=0.378), cigarette smoking (P=0.392), alcohol drinking (P=0.093). Correlation analysis suggested that DcR3 expressions were positively correlated with clinical stage (r=-0.213, P=0.024), lymph node metastasis (r=-0.568, ＜0.001), histological differentiation (r=-0.285, P=0.002). However, DcR3 expressions were not positively correlated with age, gender, cigarette smoking, alcohol drinking (P＞0.093). Conclusion: In oesophageal squamous cell carcinoma, expressions of DcR3 protein were overexpressed and positively correlated with tumor progression and invasion. DcR3 protein expression may serve as a candidate prognostic biomarker in oesophageal squamous cell carcinoma progression. [ABSTRACT FROM AUTHOR] more...