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Objective To analyze the clinical characteristics of patients with relapsed/refractory multiple myeloma (RRMM) after CAR ⁃ T cell therapy, and to explore the possible effective strategies for such patients in the future. Methods Patients with RRMM who were hospitalized in Beijing Chao⁃Yang Hospital, Capital Medical University from January 2020 to June 2024 were selected as the study subjects, and clinical characteristics and survival and survival after CAR⁃T cell therapy were analyzed. Results A total of 14 eligible RRMM patients who collected by the medical record system received CAR⁃T cell therapy targeting BCMA, with the median progression⁃free survival (PFS) of 17 months (range: 3-47 months）. At the time of disease recurrence and progression, 1 patient had extramedullary relapse, 2 patients developed secondary plasma cell leukemia,and 11 patients were intramedullay recurrence. Cytogenetics was examined in 7 patients, of which 4 patients with 1 high⁃risk gene, 1 patient with two high⁃risk genes. In the first salvage regimens, the commonly used agents included Daratumumab (6 cases）, Pomalidomide (5 cases）, and Carfilzomib (3 cases), and 3 patients were enrolled in the clinical trials. Among the 13 evaluable patients, the overall response rate was 61.5% (8/13）, with a complete response rate of 30.8% (4/13) and a very good partial response rate of 23.1% (3/13）. The median follow ⁃up time was 15 months (range: 1-32 months）, and the median PFS was 7 months. As of the last follow⁃up, 6 patients died. The median overall survival was 32 months. 1 patient developed a secondary malignance (lung cancer）. Conclusions Patients with RRMM receiving CAR⁃T cell therapy have a poor response to the currently available agents at the time of relapse and progression. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression of long chain non-coding RNA (lncRNA) HIT000218960 in gastric cancer tissues and its relationship with clinicopathological characteristics and prognosis of patients. From January 2018 to June 2019,103 patients with gastric cancer who underwent surgical resection and 62 health examination volunteers who underwent gastric mucosa biopsy were selected from the 970th Hospital of the Joint Service Support Force of the People's Liberation Army of China, their corresponding tissues were taken. lncRNA HIT000218960 and high mobility group protein A2 (HMGA2) mRNA expression were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and HMGA2 positive expression was detected by immunohistochemistry. The relationship between the lncRNA HIT000218960 expression and the clinicopathological characteristics of patients with gastric cancer were analyzed. After 3 years of follow-up, Kaplan-Meier survival curve was used to analyze the prognosis of patients in different lncRNA HIT000218960 groups, and Cox regression was used to analyze the influencing factors of the prognosis of patients with gastric cancer. The lncRNA HIT000218960 and HMGA2 mRNA expression levels in gastric cancer tissues were significantly higher than those in normal gastric mucosa tissues (P<0.05), and the HMGA2 protein positive expression rate was significantly higher than that in normal gastric mucosa tissues (P<0.05). The lncRNA HIT000218960 expression in gastric cancer tissues was significantly correlated with tumor diameter, tissue differentiation degree, TNM stage and lymph node metastasis (P<0.05). Results: The lncRNA HIT000218960 level was positively correlated with HMGA2 mRNA expression (r=0.462, P<0.05). The 3-year survival rate of lncRNA HIT000218960 low expression group was significantly higher than that of lncRNA HIT000218960 high expression group (P<0. 05). Cox regression showed that moderate and low differentiation of tumor tissue, TNM stage Ⅲ, lymph node metastasis, lncRNA HIT000218960 high expression and HMGA2 mRNA high expression were risk factors for poor prognosis in patients with gastric cancer (P<0.05). Conclusion: The lncR NA HIT000218960 is abnormally high expressed in gastric cancer tissues, which is associated with malignant progression of gastric cancer and poor prognosis of patients. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the relationship between the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) in peripheral blood before chemotherapy and the efficacy and prognosis of neoadjuvant chemotherapy of patients with breast cancer. Methods: The 105 patients with breast cancer who were underwent surgery after neoadjuvant chemotherapy in Anqing First People's Hospital affiliated to Anhui Medical University from October 2016 to January 2018 were selected as the study subjects, and they were divided into pathological complete remission (pCR) group (26 cases) and non pCR group (79 cases) according to the efficacy of neoadjuvant chemotherapy. The NLR, PLR and LMR in peripheral blood before chemotherapy of pCR group and non pCR group were compared. The predictive value of NLR, PLR and LMR in peripheral blood before chemotherapy of patients with breast cancer for the pathological effect of neoadjuvant chemotherapy was analyzed by receiver operating characteristic (ROC) curve. All patients were followed up for 5 years after surgery, and divided into high NLR, PLR, LMR groups and low NLR, PLR, LMR groups based on the optimal cutoff values of NLR, PLR, and LMR determined by the ROC curve. The 5-year disease-free survival(DFS) time of NLR, PLR, and LMR groups at different levels were analyzed by K-M survival curve. Single factor and multivariate COX regression analysis of factors affecting poor prognosis. Results: The NLR and PLR before chemotherapy in the pCR group were lower than those in the non pCR group (P<0.05), while the LMR was higher than that in the non pCR group (P<0.05). The area under the curve (AUC) of the combined prediction of NLR, PLR, and LMR for the pathological efficacy of neoadjuvant chemotherapy before chemotherapy was greater than that predicted by each index alone. K-M survival curve analysis showed that the 5-year DFS of the high NLR and PLR groups before chemotherapy was lower than that of the low NLR and PLR groups (P<0.05), and the 5-year DFS of the high LMR group was higher than that of the low LMR group (P<0.05). Single factor and multivariate COX regression analysis showed that elevated the NLR and PLR were risk factors for the prognosis of breast cancer, and elevated LMR were protective factor(P<0.05). Conclusion: The pCR group had lower NLR and PLR before chemotherapy, higher LMR, and lower 5-year DFS in patients with high NLR, PLR, and low LMR. NLR, PLR and LMR have certain predictive value for the pathological effect of neoadjuvant chemotherapy, and the combination of the three can provide important reference for the evaluation of neoadjuvant chemotherapy for breast cancer. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Eastern Liaoning University (Natural Science Edition) is the property of Department of Journal of Eastern Liaoning University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Lung Cancer is the property of Chinese Journal of Lung Cancer and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To Study the influence factors for prognosis of initial onset ST elevated myocardial infarction patients. Methods: We selected 258 cases of ST-segment elevation myocardial infarction (STEMI) patients in our hospital in 2010 as research subjects, whose symptoms were onset in 24 hour, colleted patients informations of medical histories, laboratory examinations, UCG and CAG, and followed up major cardiovascular events. To analyse the statistically significant influence factors for prognosis by correlation analysis, then through Logistic regression and Cox regression analyse the influence factors for short and long-term prognosis of AMI patients. Results: The resident death rate of AMI patients was 6.2% （16/258）, and the influence factors with resident death of AMI hospitalized patients were primary PCI (r=-0.253, P=0.000, OR=0.318, 95%CI: 0.101-0.997) and fasting blood glucose levels (r=0.24, P=0.01, OR=1.136, 95%CI: 1.020-1.265); Followed up on average 7.6± 3.8 months, the total major cardiovascular events were 10.3%(25/242), the percentage of cardiac death was 2.5%(6/242); The influence factor with long-term death rate of AMI patients through Cox regression was HsCRP concentration (r=0.182, P=0.008, OR=1.223, 95%CI：1.065-1.403). Conclusion: There were several reasons for short and long-term prognosis of AMI patients. The influence factors with resident death of AMI hospitalized patients were primary PCI and fasting blood glucose levels, and the influence factor with long-term death rate of AMI patients was HsCRP. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi is the property of Editorial Board of Journal of Clinical Neurosurgery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)