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Objective: To explore the efficacy and safety of self expanding stent assisted coil embolization in the treatment of intracranial aneurysms. Methods: From January 2014 to January 2019,159 patients with intracranial aneurysms were treated with self expanding stent assisted coil embolization (group A) and 178 patients with intracranial aneurysms (group B) were treated with simple coil embolization. The operative time, postoperative hospital stay, follow-up time and complications of the two methods were compared, and the safety and efficacy of the two methods were compared by Glasgow(GOS) prognosis score and Raymond score. Results: There was no significant difference in operation time, postoperative hospitalization time and follow-up time between the two groups (P>0.05). There was significant difference in the incidence of postoperative bleeding and ischemic events between the two groups (P<0.05), but there was no significant difference in the incidence of hydrocephalus, pneumonia, mortality and disability between the two groups(P=1 after continuous correction). The GOS score of group A was higher than that of group B within 1 month and 12 months after operation, the difference was statistically significant (P<0.05); the Raymond grade of group A was better than that of group B within 1 month and 12 months after operation, the difference was statistically significant (P<0.05). Conclusion: Self expanding stent assisted coil embolization is effective for intracranial aneurysm embolization and has few postoperative complications. For patients with intracranial aneurysms, self expanding stent assisted coil embolization can improve the safety of operation and the efficacy of embolization. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical features of patients with pancreatic neuroendocrine tumor (PNET) and the influencing factors for prognosis. Methods A retrospective analysis was performed for the clinical data of 54 patients with pathologically confirmed PNET in The First Affiliated People’s Hospital of Shanghai Jiao Tong University from March 2012 to April 2019, and clinical, pathological, and imaging features and prognosis were analyzed. The chi-square test or the Fisher’s exact test was used for comparison of categorical data between groups. The Kaplan-Meier method was used for survival analysis, and the log-rank test was used for comparison between groups. Results Among the 54 patients, there were 19 male patients (35.2%) and 35 female patients (64.8%). Of all patients, 47 (87.0%) had non-functional tumors and 7 (13.0%) had functional tumors. There were 17 patients (31.5%) with TNM stage I tumor, 26 patients (48.1%) with stage II tumor, 9 patients (16.7%) with stage III tumor, and 2 patients (3.7%) with stage IV tumor. According to the World Health Organization pathological grade, 24 patients (46.2%) had G1 tumor, 22 (42.3%) had G2 tumor, and 6 (11.5%) had G3 tumor. The patients with unclear boundary of tumor on CT (χ2=8.250, P=0.010) and MRI (χ2=6.048, P=0.031) tended to have higher postoperative recurrence rate and mortality rate. Overall survival time ranged from 1 to 86 months, with a 5-year survival rate of 92.0% and a disease-free survival time of 1-71 months. The univariate analysis showed that TNM stage (χ2=9.572, P=0.023), pathological grade (χ2=7.506, P=0.023), surgical margin invasion (χ2=15.123, P＜0.001), lymph node metastasis (χ2=4.716, P=0.030), and distant metastasis (χ2=5.534, P=0.019) were associated with overall survival time in the patients with PNET. Conclusion PNET patients with unclear tumor boundary on CT and MRI tend to have poor prognosis. TNM stage, pathological grade, surgical margin invasion, lymph node metastasis, and distant metastasis are closely associated with the prognosis of patients with PNET. [ABSTRACT FROM AUTHOR]

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