9 results on '"Arnalich Fernández, Francisco"'
Search Results
2. C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19
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Giner Galvañ, Vicente, Pomares Gómez, Francisco, Quesada, José, Rubio Rivas, Manuel, Tejada Montes, Javier, Baltasar Corral, Jesús, Taboada-Martínez, María Luisa, Sánchez Mesa, Blanca, Arnalich Fernández, Francisco, Corral Beamonte, Esther del, López Sampalo, Almudena, Pesqueira Fontán, Paula, Fernández Garcés, Mar, Gómez Huelgas, Ricardo, Ramos Rincón, José, and SEMI-COVID-19 Network
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COVID-19 ,serum albumin ,C-reactive protein ,prognosis ,syndemic ,comorbidity ,Comorbiditat ,Medicine (miscellaneous) ,Comorbidity ,General Biochemistry, Genetics and Molecular Biology - Abstract
(1) Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. (2) Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. (3) Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p < 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551–0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001–1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865–0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188–1.819; p < 0.001). (4) Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course.
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- 2022
3. Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized With COVID-19 in Spain
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Ramos-Rincon, Jose-Manuel, Buonaiuto, Verónica, Ricci, Michele, Martín-Carmona, Jesica, Paredes-Ruíz, Diana, Calderón-Moreno, María, Rubio-Rivas, Manel, Beato-Pérez, José-Luis, Arnalich-Fernández, Francisco, Monge-Monge, Daniel, Vargas-Núñez, Juan-Antonio, Acebes-Repiso, Gonzalo, Mendez-Bailon, Manuel, Perales-Fraile, Isabel, García-García, Gema-María, Guisado-Vasco, Pablo, Abdelhady-Kishta, Alaaeldeen, Pascual-Pérez, Maria-de-Los-Reyes, Rodríguez-Fernández-Viagas, Cristina, Montaño-Martínez, Adrián, López-Ruiz, Antonio, Gonzalez-Juarez, Maria-Jesus, Pérez-García, Cristina, Casas-Rojo, José-Manuel, Gómez-Huelgas, Ricardo, and SEMI-COVID-19 Network
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Male ,Aging ,medicine.medical_specialty ,Age ≥ 80 ,Pneumonia, Viral ,Renal function ,030204 cardiovascular system & hematology ,Prognostic factors ,Logistic regression ,AcademicSubjects/MED00280 ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Humans ,Medicine ,Hospital Mortality ,030212 general & internal medicine ,Mortality ,Risk factor ,Retrospective Studies ,Aged, 80 and over ,SARS-CoV-2 ,business.industry ,COVID-19 ,Age = 80 ,Retrospective cohort study ,=+80%22">Age >= 80 ,Prognosis ,medicine.disease ,Comorbidity ,Hospitalization ,Ageing ,Spain ,Cohort ,AcademicSubjects/SCI00960 ,Female ,Observational study ,Geriatrics and Gerontology ,business ,Research Article - Abstract
Background Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with COVID-19. This study aims to describe the clinical characteristics of very old inpatients with COVID-19 and identify risk factors for in-hospital mortality at admission. Methods We conducted a nationwide, multicenter, retrospective, observational study in patients ≥ 80 years hospitalized with COVID-19 in 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1–May 29, 2020). The primary outcome was in-hospital mortality. A uni- and multivariate logistic regression was performed to assess predictors of mortality at admission. Results A total of 2772 consecutive patients (49.4% men, median age 86.3 years) were analyzed. Rates of atherosclerotic cardiovascular disease, diabetes mellitus, dementia, and Barthel Index < 60 were 30.8%, 25.6%, 30.5%, and 21.0%, respectively. The overall case-fatality rate was 46.9% (n: 1301) and increased with age (80–84 years: 41.6%; 85–90 years: 47.3%; 90–94 years: 52.7%; ≥95 years: 54.2%). After analysis, male sex and moderate-to-severe dependence were independently associated with in-hospital mortality; comorbidities were not predictive. At admission, independent risk factors for death were: oxygen saturation < 90%; temperature ≥ 37.8°C; quick sequential organ failure assessment (qSOFA) score ≥ 2; and unilateral–bilateral infiltrates on chest x-rays. Some analytical findings were independent risk factors for death, including estimated glomerular filtration rate < 45 mL/min/1.73 m2; lactate dehydrogenase ≥ 500 U/L; C-reactive protein ≥ 80 mg/L; neutrophils ≥ 7.5 × 103/μL; lymphocytes < 0.8 × 103/μL; and monocytes < 0.5 × 103/μL. Conclusions This first large, multicenter cohort of very old inpatients with COVID-19 shows that age, male sex, and poor preadmission functional status—not comorbidities—are independently associated with in-hospital mortality. Severe COVID-19 at admission is related to poor prognosis.
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- 2020
4. WHO Ordinal Scale and Inflammation Risk Categories in COVID-19
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Rubio-Rivas, Manuel, Mora Luján, José María, Formiga Pérez, Francesc, Arévalo-Cañas, Coral, Lebrón Ramos, Juan Manuel, Villalba García, María Victoria, Fonseca Aizpuru, Eva Maria, Díez Manglano, Jesús, Arnalich Fernández, Francisco, Romero Cabrera, Juan Luis, García García, Gema María, Pesqueira Fontan, Paula María, Vargas Núñez, Juan Antonio, Freire Castro, Santiago Jesús, Loureiro Amigo, José, Pascual Pérez, Maria de los Reyes, Alcalá Pedrajas, José Nicolás, Encinas-Sánchez, Daniel, Mella Pérez, Carmen, Ena, Javier, Gracia Gutiérrez, Anyuli, Esteban Giner, María José, Varona, José F., Millán Núñez-Cortés, Jesús, and Casas-Rojo, José Manuel
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Inflammation ,Pronòstic mèdic ,Mortalitat ,COVID-19 ,Mortality ,Prognosis ,Inflamació - Abstract
Background: The WHO ordinal severity scale has been used to predict mortality and guide trials in COVID-19. However, it has its limitations. Objective The present study aims to compare three classificatory and predictive models: the WHO ordinal severity scale, the model based on inflammation grades, and the hybrid model. Design Retrospective cohort study with patient data collected and followed up from March 1, 2020, to May 1, 2021, from the nationwide SEMI-COVID-19 Registry. The primary study outcome was in-hospital mortality. As this was a hospital-based study, the patients included corresponded to categories 3 to 7 of the WHO ordinal scale. Categories 6 and 7 were grouped in the same category. Key Results A total of 17,225 patients were included in the study. Patients classified as high risk in each of the WHO categories according to the degree of inflammation were as follows: 63.8% vs. 79.9% vs. 90.2% vs. 95.1% (p
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- 2022
5. Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19
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Roy Vallejo, Emilia, Sánchez Purificación, Aquilino, Torres Peña, José, Sánchez Moreno, Beatriz, Arnalich Fernández, Francisco, García Blanco, María, López Miranda, José, Romero Cabrera, Juan, Herrero Gil, Carmen, Bascunana, José, Rubio-Rivas, Manuel, Pintos Otero, Sara, Martínez Sempere, Verónica, Ballano Rodríguez-Solís, Jesús, Gil Sánchez, Ricardo, Luque del Pino, Jairo, González Noya, Amara, Navas Alcántara, María, Cortés Rodríguez, Begoña, Alcalá, José, Suárez Lombraña, Ana, Andrés Soler, Jorge, Gómez Huelgas, Ricardo, Casas Rojo, José, Millán Núñez-Cortés, Jesús, and SEMI-COVID-19 Network
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medicine.medical_specialty ,Angiotensin receptor ,Coronavirus disease 2019 (COVID-19) ,Pronòstic mèdic ,medicine.medical_treatment ,MACE ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Pacients hospitalitzats ,Article ,Hospital patients ,law.invention ,ACEI, ARB, COVID-19, MACE, prognosis ,03 medical and health sciences ,0302 clinical medicine ,COVID‐19 ,law ,Internal medicine ,medicine ,Clinical endpoint ,030212 general & internal medicine ,cardiovascular diseases ,Mechanical ventilation ,biology ,business.industry ,Incidence (epidemiology) ,COVID-19 ,Angiotensin-converting enzyme ,General Medicine ,ARB ,Prognosis ,Intensive care unit ,female genital diseases and pregnancy complications ,Hospitals ,biology.protein ,Medicine ,prognosis ,business ,Mace ,ACEI - Abstract
Our main aim was to describe the effect on the severity of ACEI (angiotensin-converting enzyme inhibitor) and ARB (angiotensin II receptor blocker) during COVID-19 hospitalization. A retrospective, observational, multicenter study evaluating hospitalized patients with COVID-19 treated with ACEI/ARB. The primary endpoint was the incidence of the composite outcome of prognosis (IMV (invasive mechanical ventilation), NIMV (non-invasive mechanical ventilation), ICU admission (intensive care unit), and/or all-cause mortality). We evaluated both outcomes in patients whose treatment with ACEI/ARB was continued or withdrawn. Between February and June 2020, 11,205 patients were included, mean age 67 years (SD = 16.3) and 43.1% female, 2162 patients received ACEI/ARB treatment. ACEI/ARB treatment showed lower all-cause mortality (p <, 0.0001). Hypertensive patients in the ACEI/ARB group had better results in IMV, ICU admission, and the composite outcome of prognosis (p <, 0.0001 for all). No differences were found in the incidence of major adverse cardiovascular events. Patients previously treated with ACEI/ARB continuing treatment during hospitalization had a lower incidence of the composite outcome of prognosis than those whose treatment was withdrawn (RR 0.67, 95%CI 0.63–0.76). ARB was associated with better survival than ACEI (HR 0.77, 95%CI 0.62–0.96). ACEI/ARB treatment during COVID-19 hospitalization was associated with protection on mortality. The benefits were greater in hypertensive, those who continued treatment, and those taking ARB.
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- 2021
6. C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19.
- Author
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Giner-Galvañ, Vicente, Pomares-Gómez, Francisco José, Quesada, José Antonio, Rubio-Rivas, Manuel, Tejada-Montes, Javier, Baltasar-Corral, Jesús, Taboada-Martínez, María Luisa, Sánchez-Mesa, Blanca, Arnalich-Fernández, Francisco, Del Corral-Beamonte, Esther, López-Sampalo, Almudena, Pesqueira-Fontán, Paula María, Fernández-Garcés, Mar, Gómez-Huelgas, Ricardo, and Ramos-Rincón, José Manuel
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BLOOD proteins ,SERUM albumin ,COVID-19 ,C-reactive protein ,PROGNOSIS - Abstract
(1) Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. (2) Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. (3) Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p < 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551–0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001–1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865–0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188–1.819; p < 0.001). (4) Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
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7. Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry.
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Rubio-Rivas, Manuel, Corbella, Xavier, Formiga, Francesc, Menéndez Fernández, Estela, Martín Escalante, María Dolores, Baños Fernández, Isolina, Arnalich Fernández, Francisco, Del Corral-Beamonte, Esther, Lalueza, Antonio, Parra Virto, Alejandro, Roy Vallejo, Emilia, Loureiro-Amigo, José, Álvarez Suárez, Ana María, Abadía-Otero, Jesica, Navarro De La Chica, María, Estévez González, Raquel, Hernández Milián, Almudena, Areses Manrique, María, Blázquez Encinar, Julio César, and González Noya, Amara
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COVID-19 ,PROGNOSIS ,CHRONIC kidney failure ,OBSTRUCTIVE lung diseases ,HEART failure ,LYMPHOPENIA - Abstract
(1) Background: The inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. (2) Methods: Retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. (3) Results: A total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. (4) Conclusion: The present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study.
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Josa-Laorden, Claudia, Crestelo-Vieitez, Anxela, García Andreu, María del Mar, Rubio-Rivas, Manuel, Sánchez, Marcos, Toledo Samaniego, Neera, Arnalich Fernández, Francisco, Iguaran Bermudez, Rosario, Fonseca Aizpuru, Eva Ma, Vargas Núñez, Juan Antonio, Pesqueira Fontan, Paula Maria, Serrano Ballesteros, Jorge, Freire Castro, Santiago Jesús, Pestaña Fernández, Melani, Viana García, Alba, Nuñez Rodriguez, Victoria, Giner-Galvañ, Vicente, Carrasco Sánchez, Francisco Javier, Hernández Milián, Almudena, and Cobos-Siles, Marta
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COVID-19 ,AGE differences ,ADULT respiratory distress syndrome ,GENDER ,PROGNOSIS - Abstract
There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered. [ABSTRACT FROM AUTHOR]
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- 2021
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9. The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals.
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Mateos González, María, Sierra Gonzalo, Elena, Casado Lopez, Irene, Arnalich Fernández, Francisco, Beato Pérez, José Luis, Monge Monge, Daniel, Vargas Núñez, Juan Antonio, García Fenoll, Rosa, Suárez Fernández, Carmen, Freire Castro, Santiago Jesús, Mendez Bailon, Manuel, Perales Fraile, Isabel, Madrazo, Manuel, Pesqueira Fontan, Paula Maria, Magallanes Gamboa, Jeffrey Oskar, González García, Andrés, Crestelo Vieitez, Anxela, Fonseca Aizpuru, Eva María, Aranguren Arostegui, Asier, and Coduras Erdozain, Ainara
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COVID-19 ,PROGNOSIS ,BLOOD cell count ,ADULT respiratory distress syndrome ,BLOOD cells - Abstract
Objectives: A decrease in blood cell counts, especially lymphocytes and eosinophils, has been described in patients with serious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but there is no knowledge of their potential role of the recovery in these patients' prognosis. This article aims to analyse the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Design: This work was a retrospective, multicentre cohort study of 9644 hospitalised patients with confirmed COVID-19 from the Spanish Society of Internal Medicine's SEMI-COVID-19 Registry. Setting: This study examined patients hospitalised in 147 hospitals throughout Spain. Participants: This work analysed 9644 patients (57.12% male) out of a cohort of 12,826 patients ≥18 years of age hospitalised with COVID-19 in Spain included in the SEMI-COVID-19 Registry as of 29 May 2020. Main outcome measures: The main outcome measure of this work is the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Univariate analysis was performed to determine possible predictors of death, and then multivariate analysis was carried out to control for potential confounders. Results: An increase in the eosinophil count on the seventh day of hospitalisation was associated with a better prognosis, including lower mortality rates (5.2% vs. 22.6% in non-recoverers, OR 0.234; 95% CI, 0.154 to 0.354) and lower complication rates, especially regarding the development of acute respiratory distress syndrome (8% vs. 20.1%, p = 0.000) and ICU admission (5.4% vs. 10.8%, p = 0.000). Lymphocyte recovery was found to have no effect on prognosis. Treatment with inhaled or systemic glucocorticoids was not found to be a confounding factor. Conclusion: Eosinophil recovery in patients with COVID-19 who required hospitalisation had an independent prognostic value for all-cause mortality and a milder course. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
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