23 results on '"Chen, Qin"'
Search Results
2. Cases of Yolk sac tumor associated with gynecological malignant tumor
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Wang, Shengchao, Chen, Kelie, Chen, Qin, Huang, Shuai, and Lu, Weiguo
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- 2023
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3. The validation and clinical significance of LPCAT1 down-regulation in acute myeloid leukemia
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Chen, Qin, Xu, Zijun, Lin, Jiang, Deng, Zhaoqun, Qian, Jun, and Qian, Wei
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- 2023
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4. The prognostic value of external vs internal pancreatic duct stents after pancreaticoduodenectomy in patients with FRS ≥ 4: a retrospective cohort study
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Jiang, Yuancong, Chen, Qin, Shao, Yi, Gao, Zhenzhen, Jin, Ming, Gao, Bingqiang, Zhou, Bo, and Yan, Sheng
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- 2021
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5. BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway
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Wang, Fenfen, Chen, Qin, Huang, Genping, Guo, Xuedong, Li, Na, Li, Yang, and Li, Baohua
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- 2018
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6. A prognostic model using FIGO 2018 staging and MRI-derived tumor volume to predict long-term outcomes in patients with uterine cervical squamous cell carcinoma who received definitive radiotherapy.
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Zang, Lele, Chen, Qin, Lin, An, Chen, Jian, Zhang, Xiaozhen, Fang, Yi, and Wang, Min
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SQUAMOUS cell carcinoma , *PROGNOSTIC models , *PROGNOSIS , *TUMOR classification , *TREATMENT effectiveness - Abstract
Background: Uterine cervical carcinoma is a severe health threat worldwide, especially in China. The International Federation of Gynecology and Obstetrics (FIGO) has revised the staging system, emphasizing the strength of magnetic resonance imaging (MRI). We aimed to investigate long-term prognostic factors for FIGO 2018 stage II–IIIC2r uterine cervical squamous cell carcinoma following definitive radiotherapy and establish a prognostic model using MRI-derived tumor volume. Methods: Patients were restaged according to the FIGO 2018 staging system and randomly grouped into training and validation cohorts (7:3 ratio). Optimal cutoff values of squamous cell carcinoma antigen (SCC-Ag) and tumor volume derived from MRI were generated for the training cohort. A nomogram was constructed based on overall survival (OS) predictors, which were selected using univariate and multivariate analyses. The performance of the nomogram was validated and compared with the FIGO 2018 staging system. Risk stratification cutoff points were generated, and survival curves of low-risk and high-risk groups were compared. Results: We enrolled 396 patients (training set, 277; validation set, 119). The SCC-Ag and MRI-derived tumor volume cutoff values were 11.5 ng/mL and 28.85 cm3, respectively. A nomogram was established based on significant prognostic factors, including SCC-Ag, poor differentiation, tumor volume, chemotherapy, and FIGO 2018 stage. Decision curve analysis indicated that the net benefits of our model were higher. The high-risk group had significantly shorter OS than the low-risk group in both the training (p < 0.0001) and validation sets (p = 0.00055). Conclusions: Our nomogram predicted long-term outcomes of patients with FIGO 2018 stage II–IIIC2r uterine cervical squamous cell carcinoma. This tool can assist gynecologic oncologists and patients in treatment planning and prognosis. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Overexpression of BAALC: clinical significance in Chinese de novo acute myeloid leukemia
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Zhou, Jing-dong, Yang, Lei, Zhang, Ying-ying, Yang, Jing, Wen, Xiang-mei, Guo, Hong, Yao, Dong-ming, Ma, Ji-chun, Chen, Qin, Lin, Jiang, and Qian, Jun
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- 2015
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8. A Novel Defined RAS-Related Gene Signature for Predicting the Prognosis and Characterization of Biological Function in Osteosarcoma.
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Chen, Qin, Zhou, Xueliang, Jin, Jianqiang, Feng, Jiangbiao, Xu, Zhounan, Chen, Yunping, Zhao, Haibo, and Li, Zhongchen
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CELL-matrix adhesions , *OSTEOSARCOMA , *RAS oncogenes , *PROGNOSIS , *FOCAL adhesions - Abstract
Background. Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents with a high incidence and poor prognosis. Activation of the RAS pathway promotes progression and metastasis of osteosarcoma. RAS has been studied in many different tumors; however, the prognostic value of RAS-associated genes in OS remains unclear. On this basis, we investigated the RAS-related gene signature and explored the intrinsic biological features of OS. Methods. We obtained RNA transcriptome sequencing data and clinical information of osteosarcoma patients from the TARGET database. RAS pathway-related genes were obtained from the KEGG pathway database. Molecular subgroups and risk models were developed using consensus clustering and least absolute shrinkage and selection operator (LASSO) regression, respectively. ESTIMATE algorithm and ssGSEA analysis were used to assess the tumor microenvironment and immune penetrance between the two groups. A comprehensive review of gene ontology (GO) and KEGG analyses revealed inherent biological functional differences between the two groups. Results. The consistent clustering showed stratification of osteosarcoma patients into two subtypes based on RAS-associated genes and provided a robust prediction of prognosis. A risk model further confirmed that RAS-related genes are the best prognostic indicators for OS patients. GO analysis showed that GDP/GTP binding, focal adhesion, cytoskeletal motor activity, and cell-matrix junctions were associated with the RAS-related model group. Furthermore, RAS signaling in osteosarcoma based on KEGG analysis was significantly associated with cancer progression, with immune function and tumor microenvironment particularly affected. Conclusion. We constructed a prognostic model founded on RAS-related gene and demonstrated its predictive ability. Then, furtherly exploration of the molecular mechanisms and immune characteristics proved the role of RAS-related gene in the dysregulation in OS. [ABSTRACT FROM AUTHOR]
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- 2022
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9. TWIST1 expression and clinical significance in type I endometrial cancer and premalignant lesions
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Shen, Junhua, Chen, Qin, Li, Na, Bai, Xiaoxia, Wang, Fenfen, and Li, Baohua
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China ,animal structures ,Observational Study ,TWIST1 ,risk stratification ,Disease-Free Survival ,Endometrium ,Biomarkers, Tumor ,Humans ,Neoplasm Invasiveness ,Retrospective Studies ,Twist-Related Protein 1 ,Nuclear Proteins ,Middle Aged ,Prognosis ,Immunohistochemistry ,atypical hyperplasia ,Endometrial Neoplasms ,premalignant lesion ,Lymphatic Metastasis ,endometrial cancer ,Endometrial Hyperplasia ,Myometrium ,Female ,Research Article - Abstract
The aim of this study was to assess the correlation of TWIST1 expression with clinical parameters and the prognosis of type I endometrial cancer (EC). This retrospective study enrolled 345 patients. Immunohistochemical staining was performed on 55 normal endometrium (NE) samples, 27 atypical hyperplasia (AH) samples, and 263 type I EC samples. The association between TWIST1 staining and clinical characteristics and survival was evaluated by univariate and multivariate analyses. We found significantly higher TWIST1 expression in patients with AHs and type I ECs than NEs, but there was no significant difference between TWIST1 expression in AHs and type I ECs. Aberrant TWIST1 expression was significantly associated with clinical parameters, indicating poor prognosis and shorter patient survival. Pearsons Chi-Squared test showed that high TWIST1 expression was significantly associated with a shorter disease-free survival and overall survival. More importantly, multivariate analysis showed that high TWIST1 expression, in addition to myometrial invasion, lymph vascular space invasion, and lymph node metastasis, was an independent predictor of worse DFS in patients with type I ECs. Our findings suggest that TWIST1 might be useful in diagnosing ECs and predicting prognosis in patients with AHs and type I ECs.
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- 2020
10. Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion
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Jin‑Xin Sheng, Yan‑Dong Yang, Xiao‑Yong Wang, Shi‑Chen Qin, Xiang‑Hui Xu, Jin‑Jun Lu, Jie Yao, Guo‑Dong Zhao, Zhong Zhao, and Bin Chen
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0301 basic medicine ,Adult ,Male ,Cancer Research ,Cell cycle checkpoint ,proliferation ,Cell ,Apoptosis ,Biology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Cyclin D1 ,Cell Movement ,Stomach Neoplasms ,medicine ,Biomarkers, Tumor ,Tumor Cells, Cultured ,metastasis ,Humans ,Neoplasm Invasiveness ,Aged ,Cell Proliferation ,Aged, 80 and over ,Otx Transcription Factors ,Oncogene ,Cell growth ,gastric cancer ,General Medicine ,Articles ,Cell cycle ,Middle Aged ,medicine.disease ,Prognosis ,Molecular medicine ,OTX1 ,Gene Expression Regulation, Neoplastic ,Survival Rate ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Case-Control Studies ,Cancer research ,Female ,Follow-Up Studies - Abstract
Orthodenticle homolog 1 (OTX1) has previously been revealed to be tightly associated with the development and progression of several human tumors. However, the functional roles and underlying molecular mechanisms of OTX1 in gastric cancer (GC) remain poorly understood. In the present study, we observed that OTX1 was highly expressed in GC tissues compared with adjacent non‑tumor tissues based on a large cohort of samples from The Cancer Genome Atlas (TCGA) database. An immunohistochemical analysis indicated that OTX1 levels were increased in tumors that became metastatic compared with those in tumors that did not. This finding was significantly associated with patients who had shorter overall survival times. The knockdown of OTX1 significantly inhibited the proliferation, migration and invasion of SGC‑7901 and MGC‑803 cells. Furthermore, the knockdown of OTX1 induced cell cycle arrest in the G0/G1 phase and reduced the expression of cyclin D1. In addition, the inhibition of OTX1 led to increased GC cell apoptosis by upregulating cleaved PARP, cleaved caspase‑3 and Bax. In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells. Thus, OTX1 may be a promising novel target for molecular therapy directed toward GC.
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- 2018
11. The prognostic value of preoperative serum lactate dehydrogenase levels in patients underwent curative‐intent hepatectomy for colorectal liver metastases: A two‐center cohort study.
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Bai, Long, Lin, Ze‐Yu, Lu, Yun‐Xin, Chen, Qin, Zhou, Han, Meng, Qi, Lin, Chun‐Ping, Huang, Wan‐Lan, Wan, Yun‐Le, Pan, Zhi‐Zhong, and Wang, De‐Shen
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COLORECTAL liver metastasis ,PROGNOSIS ,LACTATE dehydrogenase ,OVERALL survival ,SURVIVAL rate ,PORTAL vein surgery ,LIVER surgery - Abstract
Background: The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between nonmetastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of curative‐intent surgery for colorectal liver metastases (CRLM). Patients and Methods: Five hundred and eighty consecutive metastatic colorectal cancer patients who underwent curative‐intent CRLM resection from Sun Yat‐sen University Cancer Center (434 patients) and Sun Yat‐sen University Sixth Affiliated Hospital (146 patients) in 2000–2019 were retrospectively collected. Overall survival (OS) was the primary end point. Cox regression model was performed to identify the prognostic values of preoperative serum LDH levels and other clinicopathology variables. A modification of the established Fong CRS scoring system comprising LDH was developed within this Chinese population. Results: At the median follow‐up time of 60.5 months, median OS was 59.5 months in the pooled cohort. In the multivariate analysis, preoperative LDH >upper limit of normal (250 U/L) was the strongest independent prognostic factor for OS (HR 1.73, 95% confidence interval [CI], 1.22–2.44; p < 0.001). Patients with elevated LDH levels showed impaired OS than patients with normal LDH levels (27.6 months vs. 68.8 months). Five‐year survival rates were 53.7% and 22.5% in the LDH‐normal group and LDH‐high group, respectively. Similar results were also confirmed in each cohort. In the subgroup analysis, LDH could distinguish the survival regardless of most established prognostic factors (number and size of CRLM, surgical margin, extrahepatic metastases, CEA, and CA19‐9 levels, etc.). Integrating LDH into the Fong score contributed to an improvement in the predictive value. Conclusion: Our study implicates serum LDH as a reliable and independent laboratory biomarker to predict the clinical outcome of curative‐intent surgery for CRLM. Composite of LDH and Fong score is a potential stratification tool for CRLM resection. Prospective, international studies are needed to validate these results across diverse populations. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Development and Validation of Nomogram to Predict Long-Term Prognosis of Critically Ill Patients with Acute Myocardial Infarction.
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Tang, Yiyang, Chen, Qin, Zha, Lihuang, Feng, Yilu, Zeng, Xiaofang, Liu, Zhenghui, Li, Famei, and Yu, Zaixin
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MYOCARDIAL infarction ,CARDIOGENIC shock ,NOMOGRAPHY (Mathematics) ,CRITICALLY ill ,OVERALL survival ,PROPORTIONAL hazards models ,PROGNOSIS - Abstract
Purpose: Acute myocardial infarction (AMI) is a common cardiovascular disease with a poor prognosis. The aim of this study was to construct a nomogram for predicting the long-term survival of critically ill patients with AMI. This nomogram will help in assessing disease severity, guiding treatment, and improving prognosis. Patients and Methods: The clinical data of patients with AMI were extracted from the MIMIC-III v1.4 database. Cox proportional hazards models were adopted to identify independent prognostic factors. A nomogram for predicting the long-term survival of these patients was developed on the basis of the results of multifactor analysis. The discriminative ability and accuracy of the multifactor analysis were evaluated according to concordance index (C-index) and calibration curves. Results: A total of 1202 patients were included in the analysis. The patients were randomly divided into a training set (n = 841) and a validation set (n = 361). Multivariate analysis revealed that age, blood urea nitrogen, respiratory rate, hemoglobin, pneumonia, cardiogenic shock, dialysis, and mechanical ventilation, all of which were incorporated into the nomogram, were independent predictive factors of AMI. Moreover, the nomogram exhibited favorable performance in predicting the 4-year survival of patients with AMI. The training set and the validation set had a C-index of 0.789 (95% confidence interval [CI]: 0.765– 0.813) and 0.762 (95% CI: 0.725– 0.799), respectively. Conclusion: The nomogram constructed herein can accurately predict the long-term survival of critically ill patients with AMI. [ABSTRACT FROM AUTHOR]
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- 2021
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13. The Prognostic Value of External vs Internal Pancreatic Duct Stents in CR-POPF after Pancreaticoduodenectomy: A Systematic Review and Meta-analysis.
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Jiang, Yuancong, Chen, Qin, Wang, Zhize, Shao, Yi, Hu, Chen, Ding, Yuan, Shen, Zhenhua, Jin, Ming, and Yan, Sheng
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PANCREATICODUODENECTOMY , *PANCREATIC duct , *PROGNOSIS , *PANCREATIC fistula , *CLINICAL trials , *RANDOMIZED controlled trials - Abstract
There is no specific evidence regarding the benefits of external and internal pancreatic duct stents after pancreaticoduodenectomy since pancreatic fistula (grade A) have been redefined with no clinical treatment effect. We aimed to reevaluate the prognostic value of external and internal stents in clinically relevant postoperative pancreatic fistula over pancreaticoduodenectomy. PubMed, Web of Science, EMBASE and the Cochrane Database were specifically searched for pertinent and original articles published before May 2019. The project has been registered in PROSPERO (Registration number: CRD42019137579). Four randomized controlled trials and six nonrandomized controlled trials with a total of 2101 patients were enrolled in this meta-analysis. The use of an external stent resulted in better performance than the use of an internal stent in terms of pancreatic fistula (grade C) (OR 0.58, P = 0.03) but did not reduce the rate of pancreatic fistula (grade B) (OR 0.99, P = 0.94) in all studies. The meta-analysis of randomized controlled trials found that the use of an external stent approached a level of significance for an increased rate of clinically relevant postoperative pancreatic fistula compared to the use of an internal stent (OR 1.40, P = 0.10) but had no significant effect on pancreatic fistula (grade B) (OR 1.34, P = 0.26) or pancreatic fistula (grade C) (OR 1.68, P = 0.62). Compared with internal stents, the use of external stent might be associated with a lower rate of pancreatic fistula (grade C). More randomized clinical trials are warranted to further explore safety and efficacy of pancreatic duct external stents. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Combined Evaluation of Preoperative Serum CEA and CA125 as an Independent Prognostic Biomarker in Patients with Early-Stage Cervical Adenocarcinoma.
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Huang, Genping, Chen, Ruizhe, Lu, Nanjia, Chen, Qin, Lv, Weiguo, and Li, Baohua
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BIOMARKERS ,RECEIVER operating characteristic curves ,CARCINOEMBRYONIC antigen ,BODY mass index ,SERUM - Abstract
Purpose: There is currently a lack of research on preoperative prognostic analysis of early-stage cervical adenocarcinoma (ADC). The purpose of our study was to clarify whether preoperative serum tumor-marker levels were of prognostic value in early-stage ADC. Patients and Methods: We performed a retrospective study of patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA1–IIA1 and pathology-proven invasive ADC. We evaluated the relationship between preoperative serum tumor-marker levels and clinicopathological characteristics, and identified the relative preoperative risk factors affecting disease-free survival (DFS) and overall survival (OS). The optimal cut-off point of meaningful tumor markers was determined by the analysis of receiver operating characteristics (ROC), and the accuracy of the results was evaluated by the area under the curve (AUC). Results: Elevated carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), squamous cell carcinoma antigen (SCC-Ag), alpha-fetoprotein (AFP), carbohydrate antigen 153 (CA153) and carbohydrate antigen 199 (CA199) were associated with certain clinicopathologic features of early-stage ADC. The combination of elevated serum CEA and CA125 was significantly associated with FIGO stage, body mass index (BMI) and LNM. Kaplan–Meier survival curve and Cox regression analyses revealed that CEA and CA125 might have significant prognostic implications in early-stage ADC patients, and the combination of elevated serum CEA and CA125 served as an independent predictor of early-stage ADC. The optimal cut-off point of serum CA125 for prediction DFS and OS was 32.60 U/mL and of serum CEA were 2.85 ng/mL and 2.05 ng/mL, respectively. The AUC showed that serum CEA was a moderate predictor of OS. Conclusion: The preoperative serum levels of CEA and CA125 might have significant prognostic implications in early-stage ADC patients. Combined preoperative serum CEA and CA125 levels independently predicted the prognosis of early-stage ADC. [ABSTRACT FROM AUTHOR]
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- 2020
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15. International normalized ratio on admission predicts the 90-day mortality of critically ill patients undergoing endarterectomy.
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Tan, Lang-Ping, Ye, Yi-Biao, Zhu, Yue, Gu, Zhi-Long, Chen, Qin-Gui, and Long, Miao-Yun
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INTERNATIONAL normalized ratio ,ENDARTERECTOMY ,CRITICALLY ill ,REGRESSION analysis ,INTERNATIONAL agencies ,LOG-rank test ,CONFIDENCE intervals - Abstract
The association of the international normalized ratio (INR) with the long-term clinical outcome of patients who undergo endarterectomy has not yet been studied. The present study therefore primarily aimed to evaluate the association of INR on admission with the 90-day mortality of critically ill patients who underwent endarterectomy during hospitalization. The Medical Information Mart for Intensive Care III database was queried for patients undergoing endarterectomy. The 90-day mortality of patients was selected as a primary endpoint. Receiver-operating characteristic (ROC) curves were plotted to present the accuracy of predictions. Kaplan-Meier curves and multivariate Cox regression analysis were performed to analyse associations. Propensity score matching (PSM) was also conducted to reduce confounding bias. A total of 230 patients were included, with 36 90-day non-survivors. Patients with a high INR (≥1.5) on admission exhibited a higher 90-day mortality than those with a low INR (<1.5; 29.09 vs. 11.43%; P=0.003). The ROC area under the curve value was 0.687 [95% confidence interval (CI), 0.571–0.780]. Kaplan-Meier plots identified divergence in survival between patients with different INR levels (log-rank test, P=0.0013). The results of the multivariate Cox regression analysis indicated that a high INR level was significantly associated with 90-day mortality (hazard ratio, 2.19; 95% CI, 1.08–4.45; P=0.0305). Analysis of the PSM cohort presented similar results. In conclusion, the INR levels of critically ill patients who undergo endarterectomy may be used to stratify their risk of 90-day mortality. [ABSTRACT FROM AUTHOR]
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- 2019
16. Unexpected uterine sarcomas in 4478 patients with electric power morcellation for leiomyomas.
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Chen, Qin, Shi, Haiyan, Lu, Weiguo, and Lu, Bingjian
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SARCOMA , *UTERINE fibroids , *HYSTERECTOMY , *MYOMECTOMY , *LAPAROSCOPY , *GYNECOLOGIC surgery , *UTERINE tumors , *DISEASE prevalence , *RETROSPECTIVE studies - Abstract
Objectives: Our objective is to investigate the prevalence, pathology and prognosis of uterine sarcomas in laparoscopic hysterectomy/myomectomy with electric power morcellation for presumed leiomyomas.Study Design: We retrospectively reviewed patients with laparoscopic power morcellation (LPM) for presumed leiomyomas in a Chinese tertiary institution by chart review from September 1, 2013 to December 31, 2016.Results: Twenty-four in 4478 patients (0.54%) with LPM for presumed leiomyomas had unexpected cancers. The patients showed the highest frequency of occult cancers (10/375, 2.6%) at 51-60 years and lowest (0/255) before 30 years. The pathology included 14 endometrial stromal sarcomas (ESS) (low-grade 12 and high-grade 2), 9 leiomyosarcomas, and 1 malignant mixed mesodermal tumor. The patients underwent abdominal re-exploration including total hysterectomy with bilateral salpingo-oophorectomy and staging surgery. Three patients were at advanced FIGO stage (IIIb-IVb) and 21 at stage I. Seven patients recurred within 1-25 (mean 6.29) months including 5 leiomyosarcomas, 1 high-grade and 1 low-grade ESS. Four recurrent patients with leiomyosarcomas and one with high-grade ESS died of disease in 1-3 months. Seventeen patients had no relapse and were alive for 6-41 (mean 24) months.Conclusions: Our study suggests that patients with LPM for presumed leiomyomas appear to have a considerable risk of unexpected cancers. Moreover, morcellation is potentially associated with adverse prognosis in patients with high-grade sarcomas. Informed consent on unexpected cancers that should be discussed before morcellation. [ABSTRACT FROM AUTHOR]- Published
- 2018
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17. Scoring model to predict outcome in critically ill cirrhotic patients with acute respiratory failure: comparison with MELD scoring models and CLIF-SOFA score.
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Zhou, Xiao-Dong, Chen, Qin-Fen, Zhang, Ming-Chun, Van Poucke, Sven, Liu, Wen-Yue, Lu, Yao, Shi, Ke-Qing, Huang, Wei-Jian, and Zheng, Ming-Hua
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CRITICALLY ill ,CIRRHOSIS of the liver ,ADULT respiratory distress syndrome ,HEALTH outcome assessment ,RISK assessment ,VASOCONSTRICTORS ,BILIRUBIN ,PATIENTS - Abstract
Background: Critically ill cirrhotic patients have a high mortality, particularly with concomitant respiratory failure on admission. There are no specific models in use for mortality risk assessment in critically ill cirrhotic patients with acute respiratory failure (CICRF). The aim is to develop a risk prediction model specific to CICRF in order to quantify the severity of illness. Methods: We analyzed 949 CICRF patients extracted from the MIMIC-III database. The novel model (ARF-CLIF-SOFA) was developed from the CLIF-SOFA score. Cox regression analysis and AUROC were implemented to test the predictive accuracy, compared with existing scores including the CLIF-SOFA score and MELD-related scores. Results: ARF-CLIF-SOFA contains PaO2/FiO2ratio, lactate, MAP, vasopressor therapy, bilirubin and creatinine (1 point each; score range: 0–6). Based on our patient cohort, the ARF-CLIF-SOFA score had good predictive accuracy for predicting the 30-, 90-day and 1-year mortality (AUROC = 0.767 at 30-day, 0.768 at 90-day, 0.765 at 1-year, respectively). Additionally, the performance of the ARF-CLIF-SOFA is superior to existing scores (all P < 0.001). Conclusion: The ARF-CLIF-SOFA score can be considered a CICRF specific score with a better predictive accuracy compared to the existing scores. [ABSTRACT FROM AUTHOR]
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- 2017
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18. Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis.
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Haipeng Wang, Zengjun Li, Yanlai Sun, Zhongfa Xu, Jianjun Han, Bao Song, Wentao Song, Chen Qin, and Lei Yin
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GENETIC overexpression ,GENE expression ,OVARIAN cancer ,CANCER prognosis ,PROGNOSIS - Abstract
Objective: To implement a meta-analysis to investigate the relationship between high-mobility group box 1 (HMGB1) overexpression in the tissue and serum of ovarian cancer patients, and to evaluate its prognostic significance. Methods: Searches were made of China National Knowledge Infrastructure, EMBASE, WanFang, PubMed, MEDLINE, and Web of Science databases up to August 2015, with no language or style restrictions. Reference lists of related studies were also carefully reviewed to identify additional articles. Results: The literature search identified a total of 12 relevant studies on HMGB1 expression for inclusion in the meta-analysis: seven in ovarian tumor tissue, four in ovarian tumor patient serum, and one in both tissue and serum. HMGB1 protein levels in ovarian cancer tissues were notably higher than those in normal ovarian tissues with no evidence of heterogeneity between studies (RD=0.64, 95% confidence interval (CI): 0.57-0.70, Z=18.70, P,0.00001, I2=15%), and also higher than those in benign tumor tissues with no evidence of heterogeneity between studies (RD=0.52, 95% CI: 0.43-0.61, Z=11.14, P,0.00001, I2=0). Serum HMGB1 levels were similarly significantly higher in ovarian cancer patients than those with benign tumors or normal ovaries. Pooled mean differences of HMGB1 in ovarian cancer patients compared with patients with benign tumors or normal ovaries were 99.32 with 95% CI: 67.82-130.81, Z=6.18, P,0.00001, and 95.34 with 95% CI: 62.11-128.57, Z=5.62, P,0.0001. The pooled relative risk of ovarian cancer with high vs low HMGB1 expression levels was 1.40 with 95% CI: 1.09-1.79, Z=2.66, P=0.008, heterogeneity I2=50%. Conclusion: This meta-analysis suggested that HMGB1 levels in both tissue and serum of ovarian cancer patients were significantly higher than those of benign tumor and normal ovarian samples. High serum or tissue HMGB1 expression may therefore be an effective molecular marker for ovarian benign or malignant tumor diagnosis and patient prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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19. DDX43 promoter is frequently hypomethylated and may predict a favorable outcome in acute myeloid leukemia.
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Lin, Jiang, Chen, Qin, Yang, Jing, Qian, Jun, Deng, Zhao-qun, Qian, Wei, Chen, Xing-xing, Ma, Ji-chun, Xiong, Dong-sheng, Ma, Yu-juan, An, Cui, and Tang, Chun-yan
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ACUTE myeloid leukemia treatment , *POLYPEPTIDES , *METHYLATION , *HEALTH outcome assessment , *GENE expression , *PROMOTERS (Genetics) - Abstract
Abstract: DEAD box polypeptide 43 (DDX43), a cancer/testis antigen (CTA), has been found to be overexpressed in various solid tumors and some hematologic malignancies. In the present work hypomethylation of the DDX43 gene was detected in 15% (32/214) of primary acute myeloid leukemia (AML) using real-time quantitative methylation-specific PCR (RQ-MSP). The level of DDX43 expression was correlated with DDX43 hypomethylation (R =0.277, P =0.014). Moreover, bisulfite sequencing confirmed the significant correlation between the methylation density and the level of DDX43 hypomethylation. Additionally, restoration of DDX43 expression in the K562 cell line by 5-aza-2′-deoxycytidine treatment confirmed a direct contribution of methylation in regulating the DDX43 gene. DDX43 hypomethylation was observed more frequently in favorable group (21.4%) and intermediate group (15.8%) than in poor group (0%) (P =0.009). AML patients with DDX43 hypomethylation had a better overall survival (median not obtained) than those with DDX43 methylation (median 8 months, 95% confidence interval 5.6–10.4 months) (P =0.014). In summary, the DDX43 gene is activated by promoter hypomethylation and DDX43 hypomethylation may be a favorable prognostic factor in AML. [Copyright &y& Elsevier]
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- 2014
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20. Aberrant hypomethylation of DDX43 promoter in myelodysplastic syndrome.
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Chen, Qin, Lin, Jiang, Yao, Dong-ming, Qian, Jun, Qian, Wei, Yang, Jing, Chai, Hai-yan, Ma, Ji-chun, Deng, Zhao-qun, Wang, Cui-zhu, and Li, Yun
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METHYLATION , *CANCER genes , *MYELODYSPLASTIC syndromes , *CLINICAL trials , *HEMOGLOBINS , *CHARTS, diagrams, etc. - Abstract
The article presents information on effect of abnormal hypomethylation of DDX43, a cancer/testing gene, enhances myelodysplastic syndrome (MDS). It mentions that patients with DDX43 methylation and patients without DDX43 methylation differed only in their clinical characteristic of hemoglobin level. A table depicting DDX43 hypomethylation in MDS patient and two graphs depicting survival of MDS patient are presented.
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- 2012
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21. Prevention of Severe Respiratory Tract Infection and Prognosis in Neurosurgical Patients with Severe Tracheotomy Based on 5E Rehabilitation Nursing Model.
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Zhang, Qing, Wan, Lei, Chen, Qin, Li, Chen, Wang, Ningning, Wang, Yang, Li, Yuanyuan, Huang, Jingjing, and Hu, Qin
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REHABILITATION nursing , *NURSING models , *TRACHEOTOMY , *RESPIRATORY infections , *CONTROL groups , *PROGNOSIS - Abstract
Background. Continuous nursing based on 5E rehabilitation mode can improve the physiology and psychology of patients to some extent. The purpose of this study was to explore the effect of continuous nursing of 5E rehabilitation mode on the prevention and prognosis of severe respiratory tract infection in patients with severe tracheotomy in neurosurgery. Objective. To explore the effect of 5E rehabilitation nursing model on the prevention of severe respiratory tract infection and prognosis in patients with severe tracheotomy in neurosurgery. Methods. The starting and ending time of this study is from February 2019 to July 2021. In this paper, 60 patients with severe tracheotomy were divided into the control group and research group according to random number table method. The former group received routine nursing, and the latter group received rehabilitation nursing model based on 5E. The patients' satisfaction, oxygenation index, partial pressure of carbon dioxide, partial pressure of oxygen, SAS, SDS score, incidence of severe respiratory tract infection, and quality of life scores were compared. Results. The nursing satisfaction of the research group was higher than that of the control group (P < 0.05). 24 hours after weaning, the oxygenation index and partial pressure of oxygen in the research group were higher than those in the control group, while the partial pressure of carbon dioxide in the research group was lower than that in the control group (P < 0.05). After nursing, the scores of self-rating anxiety scale and self-rating depression scale in the research group were lower than those in the control group, and the difference was statistically significant (P < 0.05). The incidence of severe respiratory tract infection in the research group was significantly lower than that in the control group (P < 0.05). After nursing, the scores of physiological function, psychological function, social function, and health self-cognition in the research group were lower than those in the control group (P < 0.05). Conclusion. The nursing program of neurosurgical patients with severe tracheotomy based on 5E rehabilitation model can effectively enhance patients' nursing satisfaction, activities of daily living, anxiety, and depression and promote the prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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22. Effects of percutaneous coronary intervention and diabetes mellitus on short- and long-term prognosis assessed by the three-vessel quantitative flow ratio.
- Author
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Chen, Yuxiang, Zhong, Jiaxin, Chen, Lihua, Hong, Ruijin, Yan, Yuanming, Chen, Lianglong, Chen, Qin, and Luo, Yukun
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PERCUTANEOUS coronary intervention , *MYOCARDIAL infarction , *DIABETES , *MAJOR adverse cardiovascular events , *CORONARY artery disease , *PROGNOSIS - Abstract
We aimed to investigate the impact of percutaneous coronary intervention (PCI) and diabetes mellitus (DM) on short- and long-term prognosis in patients with coronary artery disease using three-vessel quantitative flow ratio (3 V-QFR) assessment. A retrospective analysis of 2440 vessels in 1181 patients who underwent PCI was performed. The patients were categorized according to the presence or absence of DM and the median 3 V-QFR. The primary outcome was the occurrence of major adverse cardiac events (MACE), defined as a combination of cardiovascular death, myocardial infarction, and ischemia-driven revascularization, over a 5-year period. The pre-PCI and post-PCI 3 V-QFR values for the entire population were 2.37 (2.04–2.56) and 2.94 (2.82–3.00), respectively. Landmark analysis showed that the incidence of MACE was comparable among all groups within the first year (log-rank p = 0.088). Over the course of 2 years, the incidence of MACE was higher in both groups with a post-PCI 3 V-QFR < 2.94 (log-rank p < 0.001). However, from 2 to 5 years, patients with DM had higher rates of MACE (log-rank p = 0.013). In the short term, a low post-PCI 3 V-QFR is a predictor of high risk for MACE. However, in the long term, DM emerges as the dominant risk factor. [ABSTRACT FROM AUTHOR]
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- 2023
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23. Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA).
- Author
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Alpert, Joseph S., Serpytis, Rokas, Serpytis, Pranas, and Chen, Qin M.
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CORONARY arteries , *MYOCARDIAL infarction , *OPTICAL coherence tomography , *CORONARY disease , *PERIPHERAL vascular diseases , *RENIN-angiotensin system , *PATIENTS , *PROGNOSIS , *CORONARY angiography - Published
- 2019
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