1. Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer.
- Author
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Bi H, Tian T, Zhu L, Zhou H, Hu H, Liu Y, Li X, Hu F, Zhao Y, and Wang G
- Subjects
- Aged, Animals, China, Colorectal Neoplasms metabolism, Colorectal Neoplasms pathology, Female, Fishes, Genome-Wide Association Study, Humans, Leukocytes metabolism, Male, Middle Aged, Polymorphism, Single Nucleotide genetics, Proto-Oncogene Proteins c-mdm2 genetics, Red Meat adverse effects, Risk Factors, S-Phase Kinase-Associated Proteins genetics, Colorectal Neoplasms genetics, DNA Copy Number Variations genetics, Prognosis, Ubiquitin-Protein Ligases genetics
- Abstract
Given that E3 ubiquitin ligases (E3) regulate specific protein degradation in many cancer-related biological processes. E3 copy number variation (CNV) may affect the development and prognosis of colorectal cancer (CRC). Therefore, we detected CNVs of five E3 genes in 518 CRC patients and 518 age, gender and residence matched controls in China, and estimated the association between E3 gene CNVs and CRC risk and prognosis. We also estimated their interactions with environmental factors and CRC risk. We find a significant association between the CNVs of MDM2 and CRC risk (amp v.s. wt: odds ratio = 14.37, 95% confidence interval: 1.27, 163.74, P = 0.032), while SKP2 CNVs may significantly decrease CRC risk (del v.s. wt: odds ratio = 0.32, 95% confidence interval: 0.10, 1.00, P = 0.050). However, we find no significant association between the CNVs of other genes and CRC risk. The only significant gene-environment interaction effects are between SKP2 CNVs and consumption of fish and/or fruit (P = 0.014 and P = 0.035) and between FBXW7 CNVs and pork intake (P = 0.040). Finally, we find marginally significant association between β-TRCP CNVs and CRC prognosis (amp v.s. wt, hazard ratio = 0.42, 95% confidence interval: 0.19, 0.97, P = 0.050).
- Published
- 2016
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