1. Prognostic Role of the Immunoscore for Patients with Urothelial Carcinoma of the Bladder Who Underwent Radical Cystectomy
- Author
-
Ze Fu Liu, Fang Jian Zhou, Dan Xie, Hui-Ming Lu, Chao Wen Huang, Xiangdong Li, Zhuo Wei Liu, Jie Wei Chen, and Li Juan Jiang
- Subjects
Male ,Oncology ,Urologic Neoplasms ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,CD8-Positive T-Lymphocytes ,Cystectomy ,03 medical and health sciences ,Lymphocytes, Tumor-Infiltrating ,0302 clinical medicine ,Surgical oncology ,Internal medicine ,Biomarkers, Tumor ,medicine ,Carcinoma ,Humans ,Stage (cooking) ,Survival rate ,Cell Proliferation ,Retrospective Studies ,Carcinoma, Transitional Cell ,business.industry ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Survival Rate ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Female ,030211 gastroenterology & hepatology ,Surgery ,business ,Follow-Up Studies - Abstract
Increasing evidence suggests that cancer progression is strongly influenced by the host immune response, which is represented by immune cell infiltrates. The T-lymphocyte-based Immunoscore is reported to be a reliable prognostic factor in colon cancer, but its significance in urothelial carcinoma of the bladder (UCB) is at an early stage of exploration. This study aimed to determine whether the tumor immune infiltrate, as evaluated by the Immunoscore, could act as a useful prognostic marker for UCB patients who have undergone radical cystectomy (RC). In this study, immunohistochemistry was used to examine the Immunoscore of 221 UCB patients who underwent RC. The Immunoscore of the patients was determined by the densities of CD3+ and CD8+ T cells at the tumor center and the invasive margin. A highly significant association between a low Immunoscore and a shortened patient survival (P
- Published
- 2019