27 results on '"Lv, Yi"'
Search Results
2. Early coagulopathy after pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial
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Zhou, Dawei, Li, Tong, Lv, Yi, Wang, Dijia, Zhang, Rongli, Lin, Qing, Wang, Chao, Zhao, Dong, Fei, Shuyang, and He, Wei
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- 2022
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3. Prognostic impact of tertiary lymphoid structures in breast cancer prognosis: a systematic review and meta-analysis
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Zhang, Na-Na, Qu, Feng-Jin, Liu, Hao, Li, Zhu-Jun, Zhang, Yu-Chi, Han, Xuan, Zhu, Zi-Yu, and Lv, Yi
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- 2021
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4. Role of miRNA in pathogenesis, diagnosis, and prognosis in hepatocellular carcinoma.
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Lv, Yi and Sun, Xiujuan
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CANCER prognosis , *LIFE expectancy , *MICRORNA , *GENE expression , *CELL permeability , *PROGNOSIS - Abstract
Hepatocellular carcinoma (HCC) is one of the most common cancers and is responsible for the second cancer‐related death globally. Many treatment regimens have been developed to cure the disease; however, life expectancy is still low. Therefore, there is an urgent need to explore new selective, specific, and robust diagnosis markers for efficient early recognition of the ailment. Along with the diagnosis, the treatment's effectiveness can be determined by prognostic markers, and miRNAs are excellent tools for the diagnosis and prognosis of HCC. In addition, the altered expression profile of a few miRNAs promotes HCC cell migration and invasion, and selective up‐ or downregulation of these responsible genes may help mitigate the disorder. On one hand, few of the miRNAs have been found to enhance angiogenesis, a crucial step of tumor growth; on the other hand, upregulation of specific miRNAs is reported to suppress angiogenesis and resulting tumor growth of HCC cells. Exosomal miRNAs have significant implications in promoting angiogenesis, increased endothelial cell permeability, tube formation, and metastasis to hepatic and pulmonary tissues. miRNA also attributes to drug resistance toward chemotherapy and the prevention of autophagy also. Identifying novel miRNA and determining their differential expression in HCC tissue may serve as a potential tool for diagnosis, prognosis, and therapy to enhance the life expectancy and quality of life of HCC patients. In the present review, we have summarized the recent advances in HCC‐related research. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Effect of diabetes mellitus on short-term prognosis of 227 pyogenic liver abscess patients after hospitalization
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Du, Zhaoqing, Zhou, Xingchen, Zhao, Junzhou, Bi, Jianbin, Ren, Yifan, Zhang, Jia, Lin, Yuxin, Wu, Zheng, Lv, Yi, Zhang, Xufeng, and Wu, Rongqian
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- 2020
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6. Lymphadenectomy for Intrahepatic Cholangiocarcinoma: Has Nodal Evaluation Been Increasingly Adopted by Surgeons over Time?A National Database Analysis
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Zhang, Xu-Feng, Chen, Qinyu, Kimbrough, Charles W., Beal, Eliza W., Lv, Yi, Chakedis, Jeffery, Dillhoff, Mary, Schmidt, Carl, Cloyd, Jordan, and Pawlik, Timothy M.
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- 2018
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7. Comparison of clinical characteristics and outcomes of pyogenic liver abscess patients < 65 years of age versus ≥ 65 years of age
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Zhang, Jia, Du, Zhaoqing, Bi, Jianbin, Wu, Zheng, Lv, Yi, Zhang, Xufeng, and Wu, Rongqian
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- 2019
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8. The impact of previous abdominal surgery on clinical characteristics and prognosis of pyogenic liver abscess
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Zhang, Jia, Du, Zhaoqing, Bi, Jianbin, Wu, Zheng, Lv, Yi, Zhang, Xufeng, and Wu, Rongqian
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Adult ,Male ,treatment ,Observational Study ,Length of Stay ,Middle Aged ,abdominal surgery ,Prognosis ,cause ,Anti-Bacterial Agents ,stomatognathic system ,Liver Abscess, Pyogenic ,Risk Factors ,Surgical Procedures, Operative ,Abdomen ,pyogenic liver abscess ,Humans ,Female ,Research Article ,Aged ,Retrospective Studies - Abstract
Many pyogenic liver abscess (PLA) patients underwent abdominal surgery before. However, little is known about the impact of previous abdominal surgery on the clinical characteristics and prognosis of PLA. The clinical data of 392 adult PLA patients who received treatment at our hospital from January 1, 2007 to December 31, 2016 were collected. The demographic data, cause, comorbidities, surgery history, clinical features, laboratory results, imaging findings, microbiological characteristics, choices of treatment, and clinical outcomes were analyzed. In all, 177 PLA patients (45.2%) underwent abdominal surgery before. The median time for the occurrence of PLA after the most recent abdominal surgery was 2.0 (interquartile range 0.25, 6.0) years. PLA patients with a previous abdominal surgery history were more likely to have underlying diseases and presented with more abnormal laboratory values. Klebsiella pneumonia and Escherichia coli were the most common pathogens. Previous abdominal surgery appeared to increase the incidence of E coli. More PLA patients without a previous abdominal surgery history required surgical drainage. However, there were no differences in PLA-related complications, days required for temperature normalization, and length of hospital stay between the 2 groups. Because a large number of PLA patients had a history of abdominal surgery, and proper screening should be performed for patients with any suspicion of a liver abscess after abdominal surgery. Despite the differences in the coexisting conditions, clinical and microbiological characteristics between PLA patients with and without a previous abdominal surgery history, the overall short-term outcomes were comparable.
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- 2018
9. Construction and validation of a nomogram for predicting cancer-specific survival in hepatocellular carcinoma patients.
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Liu, Kang, Huang, Gaobo, Chang, Pengkang, Zhang, Wei, Li, Tao, Dai, Zhijun, and Lv, Yi
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NOMOGRAPHY (Mathematics) ,HEPATOCELLULAR carcinoma ,PROGNOSIS ,DISCRIMINATION (Sociology) ,CALIBRATION - Abstract
The prognosis of patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is a research hotspot. This study aimed to incorporate important factors obtained from SEER database to construct and validate a nomogram for predicting the cancer-specific survival (CSS) of patients with HCC and ICC. We obtained patient data from SEER database. The nomogram was constructed base on six prognostic factors for predicting CSS rates in HCC patients. The nomogram was validated by concordance index (C-index), the receiver operating characteristic (ROC) curve and calibration curves. A total of 3227 patients diagnosed with HCC (3038) and ICC (189) between 2010 and 2015 were included in this study. The C-index of the nomogram for HCC patients was 0.790 in the training cohort and 0.806 in the validation cohort. The 3- and 5-year AUCs were 0.811 and 0.793 in the training cohort. The calibration plots indicated that there was good agreement between the actual observations and predictions. In conclusion, we constructed and validated a nomogram for predicting the 3- and 5-year CSS in HCC patients. We have confirmed the precise calibration and excellent discrimination power of our nomogram. [ABSTRACT FROM AUTHOR]
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- 2020
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10. Redefining Conditional Overall and Disease-Free Survival After Curative Resection for Intrahepatic Cholangiocarcinoma: a Multi-institutional, International Study of 1221 patients.
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Hu, Liang-Shuo, Zhang, Xu-Feng, Weiss, Matthew, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Soubrane, Oliver, Martel, Guillaume, Koerkamp, B. Groot, Itaru, Endo, Lv, Yi, and Pawlik, Timothy M.
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PROGRESSION-free survival ,CHOLANGIOCARCINOMA ,RESEARCH ,BILE duct tumors ,RESEARCH methodology ,CANCER relapse ,PROGNOSIS ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,LONGITUDINAL method ,HEPATECTOMY - Abstract
Objectives: To assess conditional survival (CS) according to recurrence status, as well as conditional disease-free survival (cDFS) among patients with intrahepatic cholangiocarcinoma (ICC).Methods: CS and cDFS were evaluated among ICC patients who underwent curative-intent resection for ICC by using a multi-institutional database. Five-year CS (CS5) at "x" years was calculated separately for patients who did and did not experience recurrence. The cDFS3 at "x" years was defined as the chance to be disease-free for an additional 3 years after not having experienced a recurrence for "x" years postoperatively.Results: Among 1221 patients, median OS was 36.8 months. While estimated actuarial OS decreased over time, CS5 increased as patients survived over longer periods of time and reached 93.9% at 4 years among 139 patients who did not experience a recurrence. Among the 725 (59.4%) patients who did experience a tumor recurrence, CS5 decreased to 17.7% the first postoperative year; however, CS5 subsequently increased to 79.7% for 81 patients who had survived 4 years after surgery. While actuarial DFS decreased from 54.6% at 1 year to 28.2% at 5 years, estimated cDFS3 following liver resection increased over time. Of note, patients with known risk factors for recurrence had even more marked improvements in cDFS3 over subsequent years versus patients without risk factors for recurrence.Conclusion: CS and cDFS changed over time according to the presence of disease-specific risk factors, as well as the presence of recurrence. [ABSTRACT FROM AUTHOR]- Published
- 2020
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11. Middle hepatic vein allocation in adult right lobe living donor liver transplantation
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Zeng Zhigui, Sun Liying, Zhu Zhijun, Yang Tao, Qu Wei, Gao Wei, Lv Yi, Sun Jisan, and Wei Lin
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cold storage ,Hepatic Veins ,Remnant liver ,Young Adult ,Risk Factors ,Living Donors ,medicine ,Humans ,Good outcome ,Vein ,Aged ,Transplantation ,business.industry ,Graft Survival ,Middle Aged ,Prognosis ,Lobe ,Liver Transplantation ,Surgery ,Survival Rate ,medicine.anatomical_structure ,Liver ,Female ,Living donor liver transplantation ,business ,Algorithms ,Follow-Up Studies - Abstract
Introduction When adult-to-adult living donor liver transplantation (LDLT) using the right lobe is carried out, there is disagreement between different centers as to whether the middle hepatic vein (MHV) is included or retained by the donor. Methods Ninety-two cases of adult-to-adult LDLT were performed between January 2007 and December 2010 using a right lobe graft. A protocol for MHV allocation was applied according to the donor's remnant liver volume, overall graft/recipient weight ratio (GRWR), and anatomic characteristics of the hepatic vein. Among these cases, there were 44 cases with MHV and 48 cases without MHV. No blood products were used during donor operations, and there was no occurrence of death or small-for-size syndrome after operations. Results There were statistical differences between Groups I and II according to the ages of the recipients, the actual GRWR, the weights of grafts, the cold storage time of grafts, etc. All patients recovered smoothly; one-, three-, and five-yr survival rates of patients were 96.7%, 92.4%, and 92.4% and of grafts were 95.7%, 91.3%, and 91.3%, respectively. Conclusion With a reasonable allocation protocol and precise evaluation, either MHV harvested or MHV retained to the donor during adult-to-adult LDLT using the right lobe can achieve good outcome.
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- 2014
12. Factors distinguishing invasive from pre-invasive adenocarcinoma presenting as pure ground glass pulmonary nodules.
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Yang, Huan-Huan, Lv, Yi-Lv, Fan, Xing-Hai, Ai, Zhi-Yong, Xu, Xiu-Chun, Ye, Bo, and Hu, Ding-Zhong
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PULMONARY nodules , *COMPUTED tomography , *GLASS , *PROGNOSIS , *CARCINOEMBRYONIC antigen - Abstract
Background: To investigate predictors of pathological invasiveness and prognosis of lung adenocarcinoma in patients with pure ground-glass nodules (pGGNs).Methods: Clinical and computed tomography (CT) features of invasive adenocarcinomas (IACs) and pre-IACs were retrospectively compared in 641 consecutive patients with pGGNs and confirmed lung adenocarcinomas who had undergone postoperative CT follow-up. Potential predictors of prognosis were investigated in these patients.Results: Of 659 pGGNs in 641 patients, 258 (39.1%) were adenocarcinomas in situ, 265 (40.2%) were minimally invasive adenocarcinomas, and 136 (20.6%) were IACs. Respective optimal cutoffs for age, serum carcinoembryonic antigen concentration, maximal diameter, mean diameter, and CT density for distinguishing pre-IACs from IACs were 53 years, 2.19 ng/mL, 10.78 mm, 10.09 mm, and - 582.28 Hounsfield units (HU). Univariable analysis indicated that sex, age, maximal diameter, mean diameter, CT density, and spiculation were significant predictors of lung IAC. In multivariable analysis age, maximal diameter, and CT density were significant predictors of lung IAC. During a median follow-up of 41 months no pGGN IACs recurred.Conclusions: pGGNs may be lung IACs, especially in patients aged > 55 years with lesions that are > 1 cm in diameter and exhibit CT density > - 600 HU. pGGN IACs of < 3 cm in diameter have good post-resection prognoses. [ABSTRACT FROM AUTHOR]- Published
- 2020
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13. WISP1 Predicts Clinical Prognosis and Is Associated With Tumor Purity, Immunocyte Infiltration, and Macrophage M2 Polarization in Pan-Cancer.
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Liao, Xia, Bu, Yang, Xu, Zihan, Jia, Fengan, Chang, Fan, Liang, Junrong, Jia, Qingan, and Lv, Yi
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MACROPHAGES ,CANCER prognosis ,BREAST cancer prognosis ,GENE expression profiling ,TREATMENT effectiveness ,PROGNOSIS ,PROTEIN-protein interactions ,GENE ontology - Abstract
Cancer is becoming the leading cause of death and a major public health problem. Although many advanced treatment strategies are currently in use, the general prognosis of cancer patients remains dismal due to the high frequency of recurrence, metastasis. The identification of effective biomarkers is important for predicting survival of cancer patients and improving treatment efficacy. In this study, we comprehensively analyzed WNT1-inducible-signaling pathway protein 1 (WISP1) expression and explored its correlation with prognosis in pan-cancer using tumor IMmune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis 2 (GEPIA2). We also examined correlations between WISP1 and immunocyte infiltration using TIMER. We identified genes co-expressed with WISP1 using the LinkedOmics database and analyzed associated gene ontology using Metascape. Finally, we constructed protein-protein interaction networks and examined correlations between genes co-expressed with WISP1 and immunocyte infiltration in pan-cancer. WISP1 level differed between human pan-cancer tissues and normal tissues, indicating its potential as a prognostic biomarker. WISP1 expression was correlated with tumor purity and immunocyte infiltration, especially monocyte-macrophage trafficking and M2 polarization. Genes co-expressed with WISP1 were mainly associated with extracellular matrix organization, with collagen members COL6A3 , COL5A1 , and COL8A1 being key genes correlated with macrophage infiltration and M2 polarization in pan-cancer. Conversely, in certain types of cancer with better prognoses, WISP1 was associated with low M2 macrophage infiltration. These results suggest that WISP1 affect clinical prognosis through associations with tumor purity, immune cell infiltration, and macrophage M2 polarization in pan-cancer, with collagen member proteins may serving as effector molecules of WISP1. [ABSTRACT FROM AUTHOR]
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- 2020
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14. Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection.
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Li, Fang, Li, Na, Sang, Jiao, Fan, Xiude, Deng, Huan, Zhang, Xiaoge, Han, Qunying, Lv, Yi, and Liu, Zhengwen
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LIVER cancer patients ,LIVER cancer ,HEPATITIS B virus ,T cells ,DISEASE progression ,INTERFERON gamma ,PROGNOSIS - Abstract
Background and objective: Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to CD8+ T-cell exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddase, yielding soluble Tim-3 (sTim-3). This study investigated serum sTim-3 levels in patients with chronic HBV infection of various liver diseases. Methods: Serum sTim-3 levels were quantitatively determined in 288 patients with chronic HBV infection of various liver diseases. The sTim-3 levels were analyzed in relation to liver diseases including HBV-related hepatocellular carcinoma (HCC) and overall survival of HCC patients. Results: Serum sTim-3 levels in the patients with chronic HBV infection were significantly elevated compared with healthy controls (P [ABSTRACT FROM AUTHOR]
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- 2018
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15. Lymphadenectomy for Intrahepatic Cholangiocarcinoma: Has Nodal Evaluation Been Increasingly Adopted by Surgeons over Time?A National Database Analysis.
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Xu-Feng Zhang, Qinyu Chen, Kimbrough, Charles W., Beal, Eliza W., Yi Lv, Chakedis, Jeffery, Dillhoff, Mary, Schmidt, Carl, Cloyd, Jordan, Pawlik, Timothy M., Zhang, Xu-Feng, Chen, Qinyu, and Lv, Yi
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CHOLANGIOCARCINOMA ,LYMPHADENECTOMY ,LYMPH nodes ,PROGNOSIS ,SURGICAL excision ,BILE ducts ,COMPARATIVE studies ,REPORTING of diseases ,HEPATECTOMY ,LYMPH node surgery ,RESEARCH methodology ,MEDICAL cooperation ,METASTASIS ,RESEARCH ,TUMOR classification ,BILE duct tumors ,EVALUATION research - Abstract
Background: Surgical management of intrahepatic cholangiocarcinoma routinely includes resection of the hepatic parenchyma, yet the role of lymphadenectomy (LND) is more controversial. The objective of the current study was to define overall utilization, as well as temporal trends, in the utilization of LND among patients undergoing curative-intent hepatectomy for ICC using a nationwide database.Materials and Methods: One thousand four hundred ninety-six patients who underwent curative-intent resection for ICC were identified using the SEER database from 2000 to 2013. The utilization of LND was assessed over time and by geographic region. LND utilization and the incidence of lymph node metastasis (LNM) were evaluated relative to AJCC T categories.Results: At the time of surgery, slightly over one-half of patients (n = 784, 52.4%) had at least one LN evaluated. Specifically, 613 (41.0%) patients had 1-5 LNs evaluated, whereas 171 (11.4%) patients had ≥ 6 LNs evaluated. The proportion of patients who had at least one LN evaluated at the time of surgery did not change with time (2000-2004: 50.5% vs. 2005-2009: 52.0% vs. 2010-2013: 53.7%) (p = 0.636). In contrast, the proportion of patients who had ≥ 6 LNs examined did increase (2000-2004: 6.9% vs. 2005-2009: 10.6% vs. 2009-2013: 14.3%) (p = 0.003). The risk of LNM was higher among patients with advanced T category tumors (Referent T1; T2a: OR 4.2, 95% CI 2.0-8.8, p < 0.001; T2b: OR 2.4, 95% CI 1.1-4.9, p = 0.018; T3: OR 3.6, 95% CI 1.6-7.9, p = 0.001; T4: OR 2.2, 95% CI 1.0-4.9, p = 0.049). In addition, the portion of patients with LNM varied among the different T categories (T1, 23.2%, T2a, 55.3%, T2b, 42.0%, T3, 51.4%, and T4, 39.5%; p = 0.001).Conclusions: Utilization of LND in the surgical management of ICC across the USA remained relatively low and did not change over the last decade. Selective utilization of LND may be problematic as T-stage was not a reliable predictor of nodal status with almost a quarter of patients with early stage disease having LNM. [ABSTRACT FROM AUTHOR]- Published
- 2018
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16. Early Recurrence of Neuroendocrine Liver Metastasis After Curative Hepatectomy: Risk Factors, Prognosis, and Treatment.
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Zhang, Xu-Feng, Beal, Eliza, Chakedis, Jeffery, Lv, Yi, Bagante, Fabio, Aldrighetti, Luca, Poultsides, George, Bauer, Todd, Fields, Ryan, Maithel, Shishir, Marques, Hugo, Weiss, Matthew, Pawlik, Timothy, Beal, Eliza W, Poultsides, George A, Bauer, Todd W, Fields, Ryan C, Maithel, Shishir Kumar, Marques, Hugo P, and Pawlik, Timothy M
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NEUROENDOCRINE tumors ,CANCER relapse ,HEPATECTOMY ,SURGICAL excision ,LIVER metastasis ,PROGRESSION-free survival ,THERAPEUTICS ,TUMOR treatment ,LIVER tumors ,LONGITUDINAL method ,PROGNOSIS ,TIME ,GASTROINTESTINAL tumors - Abstract
Background: Early tumor recurrence after curative resection typically indicates a poor prognosis. The objective of the current study was to investigate the risk factors, treatment, and prognosis of early recurrence of neuroendocrine tumor (NET) liver metastasis (NELM) after hepatic resection.Methods: A total of 481 patients who underwent curative-intent resection for NELM were identified from a multi-institutional database. Data on clinicopathological characteristics, intraoperative details, and outcomes were documented. The optimal cutoff value to differentiate early and late recurrence was determined to be 3 years based on linear regression.Results: With a median follow-up of 60 months, 223 (46.4%) patients developed a recurrence, including 158 (70.9%) early and 65 (29.1%) late recurrences. On multivariable analysis, pancreatic NET, primary tumor lymph node metastasis, and a microscopic positive surgical margin were independent risk factors for early intrahepatic recurrence. While recurrence patterns and treatments were comparable among patients with early and late recurrences, early recurrence was associated with worse disease-specific survival than late recurrences (10-year NELM-specific survival, 44.5 vs 75.8%, p < 0.001). Among the 34 (21.5%) patients who underwent curative treatment for early recurrence, post-recurrence disease-specific survival was better than non-curatively treated patients (10-year NELM-specific survival, 54.2 vs 26.3%, p = 0.028), yet similar to patients with late recurrences treated with curative intent (10-year NELM-specific survival, 54.2 vs 37.4%, p = 0.519).Conclusions: Early recurrence after surgery for NELM was associated with the pancreatic type, primary lymph node metastasis, and extrahepatic disease. Re-treatment with curative intent prolonged survival after recurrence, and therefore, operative intervention even for early recurrences of NELM should be considered. [ABSTRACT FROM AUTHOR]- Published
- 2017
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17. Hepatocellular carcinoma in elderly: Clinical characteristics, treatments and outcomes compared with younger adults.
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Guo, Hui, Wu, Tao, Lu, Qiang, Dong, Jian, Ren, Yi-Fan, Nan, Ke-Jun, Lv, Yi, and Zhang, Xu-Feng
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LIVER cancer ,OLDER patients ,CANCER in young adults ,PROPENSITY score matching - Abstract
The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) is expected to increase. The present study aims to evaluate the role of age on treatments and outcome of HCC patients. 1530 patients firstly diagnosed with HCC were retrospectively included and classified as older (≥65 years, n = 318, 21%) and younger patients (<65 years, n = 1212, 79%). The two groups were compared with clinical characteristics, tumor burden, Barcelona Clinics Liver Cancer (BCLC) stage, treatments and long-term prognosis. Elderly patients were more HCV infected, had more diabetes, poorer performance status, and were less aggressively treated. The proportion of HCC within BCLC stage 0-A, B or C was similar between the two groups, but elderly patients were more presented with BCLC stage D. The overall survival of older patients was poorer compared to younger patients before and after propensity score matching. However, elderly patients were less often effectively treated with surgery and loco-regional therapies across different BCLC stages. After stratified by BCLC stages or treatments, older patients showed comparable long-term outcome to younger patients. Performance status, BCLC stages and effective treatments, rather than age, was independent factors determining prognosis in the whole cohort and only elderly patients by multivariate analysis. In conclusion, older could have comparable survival to younger patients within the same tumor stage or after similar treatments. Thus, equally active treatments should be encouraged to elderly patients. [ABSTRACT FROM AUTHOR]
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- 2017
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18. Elevated serum soluble CD14 levels in chronic HBV infection are significantly associated with HBV-related hepatocellular carcinoma.
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Li, Na, Zhu, Qianqian, Yang, Cuiling, Li, Fang, Zhou, Zhihua, Lv, Yi, Sang, Jiao, Han, Qunying, and Liu, Zhengwen
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Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases including hepatocellular carcinoma (HCC). CD14 and its soluble form sCD14 play important roles in immunity and are involved in the translocation of bacteria and their products which is related to the pathogenesis in chronic HBV infection. This study investigated serum sCD14 levels in HBV chronically infected patients with various clinical diseases. Serum sCD14 levels in HBV patients were significantly elevated compared with those of healthy controls. HCC patients had significantly highest levels of serum sCD14 across all the HBV-related diseases. Serum sCD14 levels significantly discriminated HCC from other HBV-related non-HCC diseases. The area under the receiver operating characteristic curve (AUC) of sCD14 levels for HCC was significantly higher in comparison with other HBV-related non-HCC diseases. The AUC of sCD14 for HCC (0.868, 95 % CI 0.791-0.946, P < 0.001) was higher than that of alpha-fetoprotein (0.660, 95 % CI 0.508-0.811, P = 0.039). Serum level of sCD14 was associated with the overall survival (OS) of HCC patients, with sCD14 levels >20 ng/mL being significantly related to poorer OS ( P = 0.017). Multivariate regression showed that serum sCD14 level was an independent factor associated with the OS rates of HBV-related HCC patients (HR 2.544, 95 % CI 1.169-5.538, P = 0.019). HCC resection resulted in a significant decrease of sCD14 levels ( P < 0.001). These findings suggest the potential role of sCD14 in the pathogenesis of chronic HBV infection, especially the development of HCC, and the potential usefulness of sCD14 as a biomarker for discriminating clinical diseases and predicting survival of HCC patients in chronic HBV infection. [ABSTRACT FROM AUTHOR]
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- 2016
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19. Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: A systematic review and meta-analysis.
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Li, Mu‐Xing, Liu, Xue‐Min, Zhang, Xu‐Feng, Zhang, Jian‐Fei, Wang, Wan‐Li, Zhu, Ying, Dong, Jian, Cheng, Ji‐Wen, Liu, Zheng‐Wen, Ma, Le, and Lv, Yi
- Abstract
The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts) to evaluate the association between NLR and overall survival (OS) and progression-free survival (PFS) in patients with CRC. In addition, the relationship between NLR and clinicopathological parameters was assessed. Hazard ratio (HR) or odds ratio (OR) with its 95% confidence interval (CI) was used as the effect size estimate. Our analysis results indicated that elevated pretreatment NLR predicted poorer OS (HR: 1.813, 95% CI: 1.499-2.193) and PFS (HR: 2.102, 95% CI: 1.554-2.843) in patients with CRC. Increased NLR is also significantly associated with the poorer differentiation of the tumor (OR: 1.574, 95% CI: 1.226-2.022) and higher carcino-embryonie antigen (CEA) level (OR: 1.493, 95% CI: 1.308-1.705). By these results, we conclude that NLR gains a prognostic value for patients with CRC. NLR should be monitored in CRC patients for rational stratification of the patients and adjusting the treatment strategy. [ABSTRACT FROM AUTHOR]
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- 2014
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20. Does the Sex-Determining Region on the Y Chromosome (SRY) Correlate with Gender Disparity in Liver Disease?
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Zhang, Xu-Feng and Lv, Yi
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LIVER disease treatment , *GENETIC sex determination , *LIVER cancer , *CANCER cells , *PROGRESSION-free survival , *PHENOTYPES , *PROGNOSIS - Published
- 2015
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21. Clinical Features and Prognosis of Gas-Forming and Non-Gas-Forming Pyogenic Liver Abscess: A Comparative Study.
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Zhang, Jia, Gao, Yi, Du, Zhaoqing, Ren, Yifan, Bi, Jianbin, Wu, Zheng, Lv, Yi, and Wu, Rongqian
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PYOGENIC liver abscess , *LIVER abscesses , *PROGNOSIS , *SURGICAL drainage , *PATHOGENIC bacteria , *KLEBSIELLA pneumoniae , *BACTERIAL cultures , *ANTIBIOTICS , *KLEBSIELLA , *RETROSPECTIVE studies - Abstract
Background: Gas-forming pyogenic liver abscess (GFPLA) accounts for up to 30% of all pyogenic liver abscess (PLA) cases. However, little is known of the differences in clinical features and prognosis between GFPLA and non-GFPLA. Aim: This retrospective study compared the clinical features and prognosis of GFPLA and non-GFPLA. Patients and Methods: Data for 392 patients with PLA treated from January 1, 2007 to December 31, 2016 were reviewed. Gas-forming pyogenic liver abscess was defined as gas in the abscess. Liver abscesses were considered non-GFPLA (n = 326) or GFPLA (n = 66). The clinical features and outcomes of patients with GFPLA were compared with that of patients without GFPLA. Results: The groups were similar in gender ratio, age, smoking, drinking, and comorbidities. Klebsiella pneumoniae was the most common pathogenic bacteria, but the negative rate of bacterial culture of the non-GFPLA group was higher than that of the GFPLA. In etiologies, the GFPLA group had more biliary source infection and less cryptogenic infection. In addition, the GFPLA group had a higher rate of previous hepatobiliary surgery, especially biliary enteric anastomosis. Compared with the non-GFPLA group, the percentage of the GFPLA group with antibiotic agents combined with percutaneous drainage was higher, whereas the percentages given antibiotic agents alone and antibiotic agents combined with surgical drainage were lower. Patients with GFPLA had higher rates of sepsis and pleural effusion, and longer hospital stays than did non-GFPLA patients. No patient died during hospitalization. Conclusions: The GFPLA group had more biliary source infection and less cryptogenic infection in etiologies. Gas-forming pyogenic liver abscess is associated with past hepatobiliary surgery, especially biliary enteric anastomosis and has high rates of sepsis and long hospitalization. Thus, the patients with PLA with a history of hepatobiliary surgery should be monitored more closely in the early stage of the PLA. It needs to be recognized as a distinct clinical entity. [ABSTRACT FROM AUTHOR]
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- 2021
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22. Dynamic Prediction of Survival After Curative Resection of Intrahepatic Cholangiocarcinoma
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Gaya Spolverato, Giulia Capelli, Giulia Lorenzoni, Dario Gregori, Jin He, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lv, Timothy M. Pawlik, Surgery, Spolverato, Gaya, Capelli, Giulia, Lorenzoni, Giulia, Gregori, Dario, He, Jin, Popescu, Irinel, Marques, Hugo P, Aldrighetti, Luca, Maithel, Shishir K, Pulitano, Carlo, Bauer, Todd W, Shen, Feng, Poultsides, George A, Soubrane, Oliver, Martel, Guillaume, Koerkamp, Bas Groot, Itaru, Endo, Lv, Yi, and Pawlik, Timothy M
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Cholangiocarcinoma ,Bile Ducts, Intrahepatic ,Oncology ,Bile Duct Neoplasms ,Hepatectomy ,Humans ,Surgery ,Neoplasm Recurrence, Local ,Prognosis ,Aged - Abstract
Background The current study aimed to develop a dynamic prognostic model for patients undergoing curative-intent resection for intrahepatic cholangiocarcinoma (ICC) using landmark analysis. Methods Patients who underwent curative-intent surgery for ICC from 1999 to 2017 were selected from a multi-institutional international database. A landmark analysis to undertake dynamic overall survival (OS) prediction was performed. A multivariate Cox proportional hazard model was applied to measure the interaction of selected variables with time. The performance of the model was internally cross-validated via bootstrap resampling procedure. Discrimination was evaluated using the Harrell's Concordance Index. Accuracy was evaluated with calibration plots. Results Variables retained in the multivariable Cox regression OS model included age, tumor size, margin status, morphologic type, histologic grade, T and N category, and tumor recurrence. The effect of several variables on OS changed over time. Results were provided as a survival plot and the predicted probability of OS at the desired time in the future. For example, a 65-year-old patient with an intraductal, T1, grade 3 or 4 ICC measuring 3 cm who underwent an R0 resection had a calculated estimated 3-year OS of 76%. The OS estimate increased if the patient had already survived 1 year (79%). The discrimination ability of the final model was very good (C-index: 0.80). Conclusion The long-term outcome for patients undergoing curative-intent surgery for ICC should be adjusted based on follow-up time and intervening events. The model in this study showed excellent discriminative ability and performed well in the validation process.
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- 2022
23. Lower Education and Household Income Contribute to Advanced Disease, Less Treatment Received, and Poorer Prognosis in Hepatocellular Carcinoma.
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Zhang, Xu-Feng, Guo, Hui, and Lv, Yi
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LIVER cancer patients , *LIVER cancer , *INCOME , *SOCIOECONOMICS , *PROGNOSIS - Published
- 2017
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24. ASO Visual Abstract
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Gaya Spolverato, Giulia Capelli, Giulia Lorenzoni, Dario Gregori, Jin He, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lv, Timothy M. Pawlik, Spolverato, Gaya, Capelli, Giulia, Lorenzoni, Giulia, Gregori, Dario, He, Jin, Popescu, Irinel, Marques, Hugo P, Aldrighetti, Luca, Maithel, Shishir K, Pulitano, Carlo, Bauer, Todd W, Shen, Feng, Poultsides, George A, Soubrane, Oliver, Martel, Guillaume, Koerkamp, Bas Groot, Itaru, Endo, Lv, Yi, Pawlik, Timothy M, and Surgery
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Cholangiocarcinoma ,Bile Ducts, Intrahepatic ,Treatment Outcome ,Oncology ,Bile Duct Neoplasms ,Hepatectomy ,Humans ,Surgery ,Prognosis ,Retrospective Studies - Published
- 2022
25. The prognostic impact of tumor-infiltrating B lymphocytes in patients with solid malignancies: A systematic review and meta-analysis.
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Liu, Hao, Li, Zhuoqun, Han, Xuan, Li, Zhujun, Zhao, Yan, Liu, Fenghua, Zhu, Ziyu, Lv, Yi, Liu, Zhijun, and Zhang, Nana
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TUMOR-infiltrating immune cells , *LYMPHATIC metastasis , *B cell lymphoma , *PROGNOSIS , *B cells , *CANCER prognosis - Abstract
This study reviewed the prognostic effect of tumor-infiltrating B lymphocytes (TIBLs) on solid malignancies, to determine the potential role of TIBLs in predicting cancer patient's prognosis and their response to immunotherapy. A total of 45 original papers involving 11,099 individual patients were included in this meta-analysis covering 7 kinds of cancer. The pooled results suggested that high levels of TIBLs were correlated with favorable OS in lung, esophageal, gastric, colorectal, liver, and breast cancer; improved RFS in lung cancer; and improved DFS in gastrointestinal neoplasms. Additionally, TIBLs were significantly correlated with negative lymphatic invasion in gastric cancer, small tumor size in hepatocellular carcinoma, and negative distant metastasis in colorectal cancer. Additionally, TIBLs were reported as a discriminative feature of patients treated with immunotherapy with improved survival. We concluded that TIBLs play a favorable prognostic role among the common solid malignancie, providing theoretical evidence for further prognosis prediction for solid tumors. • Analyze and review the prognostic value of B cells in solid tumors from different systems. • Assess the relationship between tumor-infiltrating B cells and other clinicopathological parameters. • Evaluate the potential role of B cells in cancer immunotherapy. [ABSTRACT FROM AUTHOR]
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- 2023
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26. Prognostic impact of perineural invasion in intrahepatic cholangiocarcinoma: multicentre study
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Tao Wei, Xu-Feng Zhang, Jin He, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lv, Timothy M. Pawlik, Surgery, Wei, Tao, Zhang, Xu-Feng, He, Jin, Popescu, Irinel, Marques, Hugo P, Aldrighetti, Luca, Maithel, Shishir K, Pulitano, Carlo, Bauer, Todd W, Shen, Feng, Poultsides, George A, Soubrane, Oliver, Martel, Guillaume, Koerkamp, Bas Groot, Itaru, Endo, Lv, Yi, and Pawlik, Timothy M
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Cholangiocarcinoma ,Survival Rate ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Humans ,Surgery ,Neoplasm Invasiveness ,Neoplasm Recurrence, Local ,Prognosis ,Retrospective Studies - Abstract
Background The aim of this study was to investigate the prognostic impact of perineural invasion (PNI) on tumour recurrence and survival among patients with resected intrahepatic cholangiocarcinoma (ICC). Methods This was a multicentre, retrospective study of patients who underwent resection with curative intent for ICC between 2000 and 2017. The relationship between PNI, clinicopathological characteristics, and long-term survival was analysed in the overall cohort and the subset of patients with early-stage ICC. Results Among 1095 patients who underwent resection of ICC, PNI was present in 239 (21.8 per cent). In univariable analysis, PNI was associated with worse disease-free survival (DFS) (median 13.2 versus 16.1 months for patients with and without PNI respectively; P = 0.038) and overall survival (OS) (26.4 versus 41.5 months; P < 0.001). In multivariable analysis, PNI was an independent risk factor associated with reduced DFS (hazard ratio (HR) 1.56, 95 per cent c.i. 1.06 to 2.13; P = 0.019) and OS (HR 1.74, 1.16 to 2.60; P = 0.007). In subgroup analysis of patients with early-stage disease (AJCC T1–2, 981 patients; or N0, 249 patients), PNI remained associated with worse DFS (T1–2: median 13.7 versus 16.6 months in patients with and without PNI respectively, P = 0.019; N0: 11.7 versus 17.5 months, P = 0.022) and OS (T1–2: 28.5 versus 45.7 months, P < 0.001; N0: 34.9 versus 47.5 months, P = 0.036). Conclusion PNI is a strong independent predictor of tumour recurrence and long-term survival following resection of ICC with curative intent, even among patients with early-stage disease. The presence of PNI should be assessed routinely.
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- 2021
27. Efficacy of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in treatment of COVID-19: A randomized controlled trial.
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Xiao, Mingzhong, Tian, Jiaxing, Zhou, Yana, Xu, Xi, Min, Xiaojun, Lv, Yi, Peng, Miao, Zhang, Ying, Yan, Dengying, Lang, Suping, Zhang, Qing, Fan, An, Ke, Jia, Li, Xiuyang, Liu, Binbin, Jiang, Manhong, Liu, Quan, Zhu, Jinyue, Yang, Lu, and Zhu, Zheng
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COVID-19 treatment , *PILLS , *RANDOMIZED controlled trials , *COVID-19 , *CHINESE medicine - Abstract
With the global epidemic of coronavirus disease (COVID-19), China has made progress in the prevention and control of the epidemic, and traditional Chinese medicine (TCM) has played a key role in dealing with the disease's effects on the respiratory system. This randomized controlled clinical trial evaluated the clinical efficacy and prognosis of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in patients with COVID-19. A total of 283 patients participated in this clinical trial, and participants were randomly assigned to receive either 1) Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules or 2) Linahua granules, both combined with western medicine, or 3) western medicine alone for 14 days. At the end of the trial, the improvement and resolution rates of clinical symptoms and the rate of patients who progressed to severe disease status were evaluated. After 14 days of treatment, there was no significant difference in the improvement rate of clinical symptoms among the three groups (P > 0.05). Huoxiang Zhengqi dropping pills combined with Lianhua Qingwen granules has advantages in the treatment of nausea, vomiting and limb soreness. During treatment, all participants were treated with western medicine, and there was a significant difference in the use of macrolides among the three groups (P < 0.05). Specifically, the utilization rate of antibiotics in the western medicine group was significantly greater than that of the other two groups. Among the 182 diagnosed patients who completed this clinical trial, 13 patients progressed to severe disease, including one case in the Huoxiang + Lianhua group (1.6 %), five cases in the Lianhua group (8.6 %), and seven cases in the western medicine group (11.1 %). There was no statistical differences in this rate among the three groups (P > 0.05). However, the proportion of patients who progressed to severe disease in the Huoxiang + Lianhua group was the lowest, suggesting that the combination of TCM with western medicine has a potential advantage in improving the prognosis of patients with COVID-19. The use of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules combined with western medicine may have clinical advantages for COVID-19 patients in improving clinical symptoms, reducing utilization rate of anti-infective drugs, and improving patient prognosis, which could pave the way for the use of complementary medicine in treating this infection. [ABSTRACT FROM AUTHOR]
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- 2020
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