1. Short- and Long-Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
- Author
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Uribarri, Aitor, Núñez-Gil, Iván J, Conty, D Aritza, Vedia, Oscar, Almendro-Delia, Manuel, Duran Cambra, Albert, Martin-Garcia, Agustin C, Barrionuevo-Sánchez, Marisa, Martínez-Sellés, Manuel, Raposeiras-Roubín, Sergio, Guillén, Marta, Garcia Acuña, Jose Maria, Matute-Blanco, Lucía, Linares Vicente, José A, Sánchez Grande Flecha, Alejandro, Andrés, Mireia, Pérez-Castellanos, Alberto, Lopez-Pais, Javier, and RETAKO Investigators
- Subjects
Male ,Time Factors ,emociones ,humanos ,Enfermedad cardiovascular ,Emotions ,Myocardial Infarction ,030204 cardiovascular system & hematology ,Tratamiento médico ,stress ,0302 clinical medicine ,stress‐induced cardiomyopathy ,Medicine ,030212 general & internal medicine ,mediana edad ,Original Research ,Aged, 80 and over ,anciano ,Clinical course ,Middle Aged ,Prognosis ,pronóstico ,classification ,Shock (circulatory) ,outcome ,Female ,medicine.symptom ,stress-induced cardiomyopathy ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Cardiomyopathy ,Severe hypoxia ,Cardiología ,Broken heart syndrome ,03 medical and health sciences ,Benign pathology ,factores de tiempo ,Medicina preventiva ,Stress, Physiological ,Takotsubo Cardiomyopathy ,Diabetes mellitus ,Internal medicine ,Humans ,Aged ,Heart Failure ,Cardiopulmonary Resuscitation and Emergency Cardiac Care ,Takotsubo syndrome ,business.industry ,broken heart syndrome ,Hypoxia (medical) ,medicine.disease ,Enfermedades ,cardiomiopatía de Takotsubo ,business ,Stress, Psychological - Abstract
Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self-limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short- and long-term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short- and long-term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction, The RETAKO registry website has received funding from AstraZeneca.
- Published
- 2019