7 results on '"Wang, Hong-Yang"'
Search Results
2. Development of a TMErisk model based on immune infiltration in tumour microenvironment to predict prognosis of immune checkpoint inhibitor treatment in hepatocellular carcinoma.
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Yan, Zi-Jun, Yu, Chu-Ting, Chen, Lei, and Wang, Hong-Yang
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IMMUNE checkpoint inhibitors ,TUMOR microenvironment ,HEPATOCELLULAR carcinoma ,PROGNOSIS ,TREATMENT effectiveness - Abstract
Immune checkpoint inhibitor (ICI) treatment has created the opportunity of improved outcome for patients with hepatocellular carcinoma (HCC). However, only a minority of HCC patients benefit from ICI treatment owing to poor treatment efficacy and safety concerns. There are few predictive factors that precisely stratify HCC responders to immunotherapy. In this study, we developed a tumour microenvironment risk (TMErisk) model to divide HCC patients into different immune subtypes and evaluated their prognosis. Our results indicated that virally mediated HCC patients who had more common tumour protein P53 (TP53) alterations with lower TMErisk scores were appropriate for ICI treatment. HCC patients with alcoholic hepatitis who more commonly harboured catenin beta 1 (CTNNB1) alterations with higher TMErisk scores could benefit from treatment with multi-tyrosine kinase inhibitors. The developed TMErisk model represents the first attempt to anticipate tumour tolerance of ICIs in the TME through the degree of immune infiltration in HCCs. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Independent Factors and Predictive Score for Extrahepatic Metastasis of Hepatocellular Carcinoma Following Curative Hepatectomy
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Xia Yong, Gong Renyan, Wu Dong, Wan Xuying, Li Jun, Wang Hong-yang, Wang Kui, Shen Feng, Liu Jian, Wu Mengchao, Yan Zhenlin, Shi Lehua, Xue Feng, and Wang Yizhou
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Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Multivariate analysis ,Adolescent ,medicine.medical_treatment ,Cohort Studies ,Young Adult ,Risk Factors ,Internal medicine ,medicine ,Carcinoma ,Hepatectomy ,Humans ,Neoplasm Metastasis ,Young adult ,Risk factor ,Child ,Aged ,Receiver operating characteristic ,business.industry ,Liver Neoplasms ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Hepatocellular carcinoma ,Female ,Hepatobiliary ,business ,Cohort study - Abstract
Background. Postoperative extrahepatic metastasis (EHM) contributes to a poor prognosis in patients with hepatocellular carcinoma (HCC) after hepatectomy. This study was aimed to develop a practical method that can be used to predict postoperative EHM. Methods. In total, 578 patients were enrolled. We analyzed the clinicopathological features of the tumors and did a long-term follow-up to observe HCC recurrence. Postoperative EHM was detected in 136 patients, and multivariate analysis was used to confirm independent risk factors for postoperative EHM. After the factors were identified, a predictive scoring system was constructed as a weighted sum of these factors. The cutoff value that determines a high risk for EHM was defined by maximizing the Youden's index of the receiver operating characteristic curve. Results. Microvascular invasion, incomplete capsule, and larger tumor diameter were the three independent factors predictive for a high risk for EHM. The scoring system was derived with an area under the curve (AUC) of 0.81 for postoperative 10-year EHM prediction. A cutoff value of 43 was derived and validated with a sensitivity >90% and specificity >60% to predict the development of EHM. This system was further verified in a subgroup of Barcelona Clinic Liver Cancer stage 0–A patients with an AUC of 0.82. When the cutoff value was set at 43, the sensitivity and specificity were 90.38% and 64.88%, respectively. Conclusions. Our predictive scoring system may be used to identify HCC patients who have a high risk for EHM following curative hepatectomy.
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- 2012
4. Prognostic significance of cytoskeleton-associated membrane protein 4 and its palmitoyl acyltransferase DHHC2 in hepatocellular carcinoma.
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Li, Shuang‐Xi, Tang, Gu‐Sheng, Zhou, Dong‐Xun, Pan, Yu‐Fei, Tan, Ye‐Xiong, Zhang, Jian, Zhang, Bo, Ding, Zhi‐Wen, Liu, Li‐Juan, Jiang, Tian‐Yi, Hu, He‐Ping, Dong, Li‐Wei, and Wang, Hong‐Yang
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MEMBRANE proteins ,LIVER cancer patients ,POLYMERASE chain reaction ,KAPLAN-Meier estimator ,LOG-rank test ,LIVER cancer ,PROGNOSIS - Abstract
BACKGROUND The functions of cytoskeleton-associated membrane protein 4 (CKAP4), one kind of type II transmembrane protein, are associated with the palmitoyl acyltransferase DHHC2. The objective of the current study was to investigate CKAP4/DHHC2 expression and its prognostic significance in patients with hepatocellular carcinoma (HCC). METHODS Two independent cohorts of 416 patients with HCC were enrolled. All the patients included had defined clinicopathologic and follow-up data. Using real-time polymerase chain reaction and immunohistochemical assay, CKAP4 and DHHC2 expression were evaluated. The association between CKAP4/DHHC2 expression and HCC-specific disease-free survival and overall survival was analyzed by Kaplan-Meier curves, the log-rank test, and Multivariate Cox regression analyses. RESULTS The data documented that CKAP4 expression was much higher in HCC tumor tissues compared with adjacent normal tissues and its expression was significantly correlated with tumor size, intrahepatic metastases, portal venous invasion, and Barcelona Clinic Liver Cancer stage of disease in 2 cohorts of patients. On survival analysis, patients with high CKAP4 expression appeared to have a favorable overall survival and a longer disease-free survival compared with those with low expression. DHHC2 expression was also examined in tissue microarray analysis by immunohistochemistry and the results demonstrated that 87.6% of the cases had low expression of DHHC2. Kaplan-Meier analysis indicated that a high level of DHHC2 expression predicted favorable overall survival and disease-free survival rates in both the training cohort and validation set. Furthermore, the combination of CKAP4 and DHHC2 was found to have a more powerful efficiency in prognosis prediction than either one alone. CONCLUSIONS To the best of our knowledge, the current study is the first to demonstrate that the expression of CKAP4 and its palmitoyl acyltransferase DHHC2 correlates with disease progression and metastasis in patients with HCC and may provide prognostic and therapeutic value. Cancer 2014;120:1520-1531. © 2014 American Cancer Society. [ABSTRACT FROM AUTHOR]
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- 2014
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5. Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2.
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Qin, Chen-Jie, Zhao, Ling-Hao, Zhou, Xu, Zhang, Hui-Lu, Wen, Wen, Tang, Liang, Zeng, Min, Wang, Ming-Da, Fu, Gong-Bo, Huang, Shuai, Huang, Wei-Jian, Yang, Yuan, Bao, Zhi-Jun, Zhou, Wei-Ping, Wang, Hong-Yang, and Yan, He-Xin
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IMMUNOSTAINING , *IMMUNOHISTOCHEMISTRY techniques , *GENE expression , *MOLECULAR genetics , *CYTOKINES , *OBESITY complications , *ANIMAL experimentation , *BIOCHEMISTRY , *CELL lines , *CELL physiology , *COMPARATIVE studies , *DIET , *GENES , *HEPATOCELLULAR carcinoma , *INFLAMMATORY mediators , *LIVER tumors , *PHENOMENOLOGY , *RESEARCH methodology , *MEDICAL cooperation , *METASTASIS , *MICE , *OBESITY , *PROGNOSIS , *PROTEOLYTIC enzymes , *RATS , *RESEARCH , *EVALUATION research , *DISEASE progression - Abstract
Obesity is a major risk factor for hepatocellular carcinoma (HCC) and is typically accompanied by higher levels of serum dipeptidyl peptidase 4 (DPP4). However, the role of DPP4 in obesity-promoted HCC is unclear. Here, we found that consumption of a high-fat diet (HFD) promoted HCC cell proliferation and metastasis and led to poor survival in a carcinogen-induced model of HCC in rats. Notably, genetic ablation of DPP4 or treatment with a DPP4 inhibitor (vildagliptin) prevented HFD-induced HCC. Moreover, HFD-induced DPP4 activity facilitated angiogenesis and cancer cell metastasis in vitro and in vivo, and vildagliptin prevented tumor progression by mediating the pro-angiogenic role of chemokine ligand 2 (CCL2). Loss of DPP4 effectively reversed HFD-induced CCL2 production and angiogenesis, indicating that the DPP4/CCL2/angiogenesis cascade had key roles in HFD-associated HCC progression. Furthermore, concomitant changes in serum DPP4 and CCL2 were observed in 210 patients with HCC, and high serum DPP4 activity was associated with poor clinical prognosis. These results revealed a link between obesity-related high serum DPP4 activity and HCC progression. Inhibition of DPP4 may represent a novel therapeutic intervention for patients with HCC. [ABSTRACT FROM AUTHOR]
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- 2018
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6. PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients.
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Han, Tao, Xiang, Dai-Min, Sun, Wen, Liu, Na, Sun, Huan-Lin, Wen, Wen, Shen, Wei-Feng, Wang, Ruo-Yu, Chen, Cheng, Wang, Xue, Cheng, Zhuo, Li, Heng-Yu, Wu, Meng-Chao, Cong, Wen-Ming, Feng, Gen-Sheng, Ding, Jin, and Wang, Hong-Yang
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LIVER cancer patients , *LIVER cancer , *PROTEIN-tyrosine phosphatase , *GENETIC overexpression , *CANCER invasiveness , *IMMUNOBLOTTING , *PROGNOSIS - Abstract
Background & Aims We have previously reported that Shp2, a tyrosine phosphatase previously known as a pro-leukemogenic molecule, suppresses the initiation of hepatocellular carcinoma (HCC). However, the role of Shp2 in HCC progression remains obscure. Methods Shp2 expression was determined in human HCC using real-time PCR, immunoblotting and immunohistochemistry. Clinical significance of Shp2 expression was analyzed in 301 HCC tissues with clinico-pathological characteristics and follow-up information. Short hairpin RNA was utilized to investigate the function of Shp2 in hepatoma cell behavior. Role of Shp2 in HCC progression was monitored through nude mice xenograft assay. Kinase activity assay and co-immunoprecipitation were used for mechanism analysis. Results Elevated expression of Shp2 was detected in 65.9% (394/598) of human HCCs, and its levels were even higher in metastasized foci. Overexpression of Shp2 correlated well with the malignant clinico-pathological characteristics of HCC and predicted the poor prognosis of patients. Interference of Shp2 expression suppressed the proliferation of hepatoma cells in vitro and inhibited the growth of HCC xenografts in vivo . Down-regulation of Shp2 attenuated the adhesion and migration of hepatoma cells and diminished metastasized HCC formation in mice. Our data demonstrated that Shp2 promotes HCC growth and metastasis by coordinately activating Ras/Raf/Erk pathway and PI3-K/Akt/mTOR cascade. Moreover, down-regulation of Shp2 enhanced the sensitivity of hepatoma cells upon sorafenib treatment, and patients with low Shp2 expression exhibited superior prognosis to sorafenib. Conclusions Shp2 promotes the progression of HCC and may serve as a prognostic biomarker for patients. [ABSTRACT FROM AUTHOR]
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- 2015
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7. Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection.
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Li, Min-hong, Dong, Li-wei, Li, Shuang-xi, Tang, Gu-sheng, Pan, Yu-fei, Zhang, Jian, Wang, Hui, Zhou, Hua-bang, Tan, Ye-xiong, Hu, He-ping, and Wang, Hong-yang
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CHOLANGIOCARCINOMA , *SURGICAL excision , *LYMPHATIC metastasis , *LYMPH node surgery , *ONCOLOGIC surgery , *CANCER-related mortality , *CYTOSKELETON , *PROGNOSIS , *PATIENTS - Abstract
Highlights: [•] CKAP4 was overexpressed in the majority of ICC cases. [•] CKAP4 was significantly associated with lymph node metastasis features. [•] CKAP4 was an independent predictor for overall survival for ICC. [Copyright &y& Elsevier]
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- 2013
- Full Text
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