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Background The improvement efficacy of consolidation chemotherapy after definitive concurrent chemotherapy and radio-therapy (CCRT) on the prognosis of patients with locally advanced esophageal squamous cell carcinoma (ESCC) remains controversial. In addition, there is a lack of nutritional risk screening tools which can consistently and accurately predict the survival of patients with esophageal cancer. Objective To investigate the effect of consolidation chemotherapy on the prognosis of patients with locally advanced ESCC receiving definitive CCRT. Methods A total of 223 patients with ESCC who received definitive CCRT in the department of radiotherapy, the Fourth Hospital of Hebei Medical University from January 2013 to December 2018 were selected as the research objects and divided into the simple CCRT group (n=87) and combined consolidation chemotherapy group (n=136) according to chemoradiotherapy regimen adopted by the patients. General data, ECOG score, tumor site, tumor length, TNM stage, radiotherapy dose, irradiation mode and chemotherapy regimen of the included patients were collected by electronic medical record system. Nutritional Risk Screening 2002 (NRS 2002) was used to score the nutritional status of the patients before chemoradiotherapy. Efficacy evaluation was performed within 1 month after CCRT, including complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD). Patients were followed up by telephone (completed by the follow-up center) and outpatient review until 2022-09-30, with overall survival (OS), local relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS) collected. Survival curves of OS, LRRFS and DMFS were plotted by Kaplan-Meier method and compared by Log-rank test. Univariate and multivariate Cox risk regression models were used to explore the influencing factors of patient prognosis. Results There was no significant difference in baseline data between the simple CCRT group and combined consolidation chemotherapy group (P>0.05). There was no significant difference in the rates of OS, LRRFS and DMFS between the two groups (χ2=1.942, 0.743, 1.272; P=0.163, 0.389, 0.259). There were significant differences in the rates of OS, LRRFS and DMFS between patients with NRS 2002 score

Background The incidence of cervical and upper thoracic esophageal cancer is relatively low, with difficulties and controversies of mode in treatment, lack of convenient and accurate prognostic biomarkers, and poor overall prognosis. Objective To investigate the long-term prognosis of patients with cervical and upper thoracic esophageal squamous cell carcinoma under concurrent chemotherapy and radio-therapy (CCRT) . Methods Patients with cervical and thoracic upper esophageal cancer who received CCRT in the Department of Radiotherapy of the Fourth Hospital of Hebei Medical University from January 2013 to December 2017 were selected as the research subjects. General data, Eastern Cooperative Oncology Group (ECOG) score, tumor site, tumor length, TNM stage, radiotherapy dose, irradiation mode, chemotherapy regimen, toxic and side effects were collected by electronic medical record system, and neutrophil to lymphocyte ratio (dNLR) was calculated. The patients were divided into the dNLR

Abstract: Aims: Infection of Helicobacter pylori, a major cause of various gastric diseases, has been reported to play a role in the process of tumorigenesis and progression of gastric carcinoma. Some studies have been devoted to the relationship between H. pylori infection and oesophageal cancer and have yielded conflicting results. Whether infection of H. pylori is a risk factor for this cancer remains uncertain. In this study we aimed to evaluate the association of H. pylori infection with oesophageal cancer risk. Materials and methods: The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications, then the extracted data were further analysed by systematic meta-analyses. Results: In total, 195 articles were identified, of which 12 case–control studies concerning oesophageal cancer were selected. Oesophageal adenocarcinoma risk for H. pylori infection was 0.58-fold (95% confidence interval 0.48–0.70) (Z =5.79, P <0.01) compared with the controls. Oesophageal squamous cell carcinoma risk was 0.80-fold (95% confidence interval 0.45–1.43) (Z =0.75, P >0.05) compared with the controls. Compared with CagA-negative H. pylori, CagA-positive H. pylori markedly decreased oesophageal cancer risk. Conclusion: The pooled data suggest infection of H. pylori as a possible preventive factor for oesophageal adenocarcinoma and failed to suggest a significant association between H. pylori infection and oesophageal squamous cell carcinoma. [Copyright &y& Elsevier]