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Start Over Descriptor "Baia" Topic propafenone
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1. MCASE study of the multidrug resistance reversal activity of propafenone analogs.

Author

Klopman, Gilles, Hao Zhu, Ecker, Gerhard, and Chiba, Peter

Subjects
*MULTIDRUG resistance, *DRUG resistance, *PROPAFENONE, *MYOCARDIAL depressants, *PHENYL compounds, *PROPYLAMINE
Abstract

A database containing 130 propafenone type chemicals which have been tested for their multidrug resistance (MDR) reversal activity was compiled. Using the Multiple Computer-Automated Structure Evaluation (MCASE) program to analyze this database, an underlying relationship between MDR reversal activity and octanol/water partition coefficient was found. An MDR reversal model was created based on this database by the baseline activity identification algorithm (BAIA) of the MCASE program. The main phamacophores relevant to MDR reversal activity were identified. [ABSTRACT FROM AUTHOR]

Published
2003
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