1. A toxicological evaluation of 2-dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride.
- Author
-
Dimmock JR, Zello GA, Vashishtha SC, Hayes SJ, Mutalik S, Kumar S, Venkatesh M, and Udupa N
- Subjects
- Animals, Blood Cell Count, Bone Marrow Cells drug effects, Cholesterol blood, Creatinine blood, Escherichia coli drug effects, Escherichia coli genetics, Injections, Intraperitoneal, Liver Function Tests, Mannich Bases chemistry, Mannich Bases toxicity, Mice, Micronucleus Tests, Mutagenicity Tests, Salmonella typhimurium drug effects, Salmonella typhimurium genetics, Triglycerides blood, Urea blood, Antineoplastic Agents toxicity, Propiophenones toxicity
- Abstract
2-Dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride (3) is a novel cytotoxic and anticancer agent. The objective of this study was to obtain information pertaining to possible toxic symptoms detected by in vivo evaluations in mice and an in vitro test for mutagenicity. The data obtained revealed that 3 had no effect on alanine transaminase, aspartate transaminase, HDL cholesterol and protein concentrations in sera nor were variations in the numbers of red and white blood cells detected. Furthermore autopsies of treated mice revealed no pathological symptoms in the heart, kidney, brain, spleen and testes. However elevation of the concentrations of total cholesterol, triglycerides, creatinine and urea were noted in treated mice as well as inflammation of the liver and lungs. Chromosomal aberrations were detected in a micronuclei test. In the Ames test, compound 3 was converted into one or more mutagens in the presence (but not the absence) of a murine liver homogenate. Thus future molecular modifications of 3 should bear in mind approaches to reduce or minimize unwanted side effects.
- Published
- 2003